Patents by Inventor Michelle Matter

Michelle Matter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF MODULATING CELL DEATH BASED ON THE BIT1/AES REGULATORY PATHWAY
    Publication number: 20120014974
    Abstract: The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1 polypeptide, or active fragment thereof, and an AES polypeptide, or active fragment thereof, with an agent under conditions that allow the Bit1 polypeptide or active fragment thereof to associate with the AES polypeptide or active fragment thereof; and detecting an altered association of the Bit1 polypeptide or active fragment thereof and the AES polypeptide or active fragment thereof, where an altered association indicates that the agent is an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. Such an effective agent can modulate apoptosis and can be a useful therapeutic agent.
    Type: Application
    Filed: June 6, 2011
    Publication date: January 19, 2012
    Applicant: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Yiwen Jan, Michelle Matter, Jih-tung Pai, Erkki Ruoslahti
  • Methods of modulating cell death based on the Bit-1/AES regulatory pathway
    Patent number: 8017326
    Abstract: The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1 polypeptide, or active fragment thereof, and an AES polypeptide, or active fragment thereof, with an agent under conditions that allow the Bit1 polypeptide or active fragment thereof to associate with the AES polypeptide or active fragment thereof; and detecting an altered association of the Bit1 polypeptide or active fragment thereof and the AES polypeptide or active fragment thereof, where an altered association indicates that the agent is an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. Such an effective agent can modulate apoptosis and can be a useful therapeutic agent.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: September 13, 2011
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Yiwen Jan, Michelle Matter, Jih-Tung Pai, Erkki Ruoslahti
  • METHODS OF MODULATING CELL DEATH BASED ON THE BIT-1/AES REGULATORY PATHWAY
    Publication number: 20090022711
    Abstract: The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1 polypeptide, or active fragment thereof, and an AES polypeptide, or active fragment thereof, with an agent under conditions that allow the Bit1 polypeptide or active fragment thereof to associate with the AES polypeptide or active fragment thereof; and detecting an altered association of the Bit1 polypeptide or active fragment thereof and the AES polypeptide or active fragment thereof, where an altered association indicates that the agent is an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. Such an effective agent can modulate apoptosis and can be a useful therapeutic agent.
    Type: Application
    Filed: June 6, 2008
    Publication date: January 22, 2009
    Applicant: The Burnham Institute
    Inventors: Yiwen Jan, Michelle Matter, Jih-tung Pai, Erkki Ruoslahti
  • Methods of modulating cell death based on the Bit1/AES regulatory pathway
    Patent number: 7393653
    Abstract: The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1 polypeptide, or active fragment thereof, and an AES polypeptide, or active fragment thereof, with an agent under conditions that allow the Bit1 polypeptide or active fragment thereof to associate with the AES polypeptide or active fragment thereof; and detecting an altered association of the Bit1 polypeptide or active fragment thereof and the AES polypeptide or active fragment thereof, where an altered association indicates that the agent is an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. Such an effective agent can modulate apoptosis and can be a useful therapeutic agent.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: July 1, 2008
    Assignee: The Burnham Institute
    Inventors: Yiwen Jan, Michelle Matter, Jih-tung Pai, Erkki Ruoslahti
  • Methods of modulating cell death based on the Bit1/AES regulatory pathway
    Publication number: 20050054011
    Abstract: The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1 polypeptide, or active fragment thereof, and an AES polypeptide, or active fragment thereof, with an agent under conditions that allow the Bit1 polypeptide or active fragment thereof to associate with the AES polypeptide or active fragment thereof; and detecting an altered association of the Bit1 polypeptide or active fragment thereof and the AES polypeptide or active fragment thereof, where an altered association indicates that the agent is an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. Such an effective agent can modulate apoptosis and can be a useful therapeutic agent.
    Type: Application
    Filed: September 5, 2003
    Publication date: March 10, 2005
    Inventors: Yiwen Jan, Michelle Matter, Jih-tung Pai, Erkki Ruoslahti