Patent number: 7151108
Abstract: A compound selected from those of formula (I): wherein: W1 represents, together with carbon to which it is bonded, phenyl, pyridyl, Z represents a group of formula U—V as defined in the description, Q1 represents oxygen, NR2 as defined in the description, Q2 represents oxygen, NR?2 as defined in the description, X1, X2, X?1 and X?2 each represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1, Y2, Y?1 and Y?2 each represents hydrogen, or X1 and Y1, X2 and Y2, X?1 and Y?1, X?2 and Y?2 with carbon carrying them, together form carbonyl or thiocarbonyl, R1 is as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
Type:
Grant
Filed:
September 26, 2003
Date of Patent:
December 19, 2006
Assignee:
Les Laboratories Servier
Inventors:
Michelle Prudhomme, Bernadette Hugon, Fabrice Anizon, John Hickman, Alain Pierre, Roy Golsteyn, Pierre Renard, Bruno Pfeiffer
Patent number: 6569858
Abstract: A compound selected from those of formula (I):
wherein:
R1 and R2, which may be identical or different, represent a group of formula U-V wherein U represents single bond, or alkylene which is optionally substituted and/or unsaturated, and V is as defined in the description,
G represents oxygen, or NR3 wherein R3 is as defined in the description,
X represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y represents hydrogen, or X+Y represents carbonyl,
X1 represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1 represents hydrogen, or X1+Y1 represents carbonyl,
R4, R5, and R6 are as defined in the description,
its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same are useful in the treatment of cancer.
Type:
Grant
Filed:
November 5, 2001
Date of Patent:
May 27, 2003
Assignee:
Les Laboratoires Servier
Inventors:
Michelle Prudhomme, Pascale Moreau, Fabrice Anizon, Christelle Marminon, Ghanem Atassi, Alain Pierre, Bruno Pfeiffer, Pierre Renard