Patents by Inventor Michelle R. Arkin

Michelle R. Arkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CASPASE 6 INHIBITORS AND USES THEREOF
    Publication number: 20230202974
    Abstract: Disclosed herein, inter alia, are compounds and methods for inhibiting Caspase 6 and the treatment of diseases, pharmaceutical composition including a compound as described herein and a pharmaceutically acceptable excipient and methods of inhibiting human Caspase 6 protein activity, the method including: contacting the human Caspase 6 protein with a compound as described herein.
    Type: Application
    Filed: November 20, 2020
    Publication date: June 29, 2023
    Inventors: Adam R. Renslo, Michelle R. Arkin, R. Jeffrey Neitz, Raymond Ng, Peter Lee
  • PROTEIN-PROTEIN INTERACTION STABILIZERS
    Publication number: 20230142739
    Abstract: Provided herein, inter alia, are stabilizers of protein-protein interactions and methods of identifying and using the same.
    Type: Application
    Filed: April 2, 2021
    Publication date: May 11, 2023
    Inventors: Michelle R. Arkin, Lucas Brunsveld, Christian Ottmann, Adam R. Renslo, R. Jeffrey Neitz, Mengqi Zhong, Kenneth K. Hallenbeck, Priyadarshini Jaishankar, Shubhankar Dutta, John K. Morrow, Eline Sijbesma, Bente Aminhan Somsen, Galen Patrick Miley, Emira Josien Visser, Peter James Cossar, Madita Wolter, Thorsten Genski, Laura Mariana Levy, Torsten Hoffmann, Dimitrios Tzalis, Dario Valenti, Markella Konstantinidou
  • TASPASE1 INHIBITORS AND USES THEREOF
    Publication number: 20230052528
    Abstract: Disclosed herein, inter alia, are compounds and methods for inhibiting Taspase1 and the treatment of cancer.
    Type: Application
    Filed: November 20, 2020
    Publication date: February 16, 2023
    Inventors: Michelle R. Arkin, R. Jeffrey Neitz, Adam R. Renslo, James Hsieh, Shubhankar Dutta, Clifford Bryant, William J. Moore, Alex G. Waterson, Lidia Sambucetti, Somnath Jana, lan M. Romaine, Alexander P. Lamers, Yassir Younis Adam, Claire Repellin
  • Modulators of the eIF2alpha pathway
    Patent number: 11220477
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: January 11, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • MODULATORS OF THE EIF2ALPHA PATHWAY
    Publication number: 20190375704
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Application
    Filed: May 21, 2019
    Publication date: December 12, 2019
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • Modulators of the eIF2alpha pathway
    Patent number: 10343981
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: July 9, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • MODULATORS OF THE EIF2ALPHA PATHWAY
    Publication number: 20170342020
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Application
    Filed: June 5, 2017
    Publication date: November 30, 2017
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • Modulators of the eIF2alpha pathway
    Patent number: 9708247
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: July 18, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • MODULATORS OF THE EIF2ALPHA PATHWAY
    Publication number: 20160096800
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Application
    Filed: September 9, 2015
    Publication date: April 7, 2016
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • Small-molecule inhibitors of interleukin-2
    Patent number: 6806279
    Abstract: Compounds of formulae I and I′, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are antagonists of IL-2/IL-2R binding; and are useful for the treatment of interleukin-2 mediated diseases, such as autoimmune diseases (such as rheumatoid arthritis, multiple sclerosis, uveitis, and psoriasis), allograft rejection, and graft-versus-host disease.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: October 19, 2004
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Michelle R. Arkin, Robert S. McDowell, Johan D. Oslob, Brian C. Raimundo, Nathan D. Waal, Chul Hyun Yu
  • Small-molecule inhibitors of interleukin-2
    Publication number: 20030149049
    Abstract: Compounds of formulae I and I′, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are antagonists of IL-2/IL-2R binding; and are useful for the treatment of interleukin-2 mediated diseases, such as autoimmune diseases (such as rheumatoid arthritis, multiple sclerosis, uveitis, and psoriasis), allograft rejection, and graft-versus-host disease.
    Type: Application
    Filed: December 17, 2001
    Publication date: August 7, 2003
    Inventors: Michelle R. Arkin, Robert S. McDowell, Johan D. Oslob, Brian C. Raimundo, Nathan D. Waal, Chul Hyun Yu