Abstract: Methods, systems, and computer-readable media are disclosed herein for predicting medication induced respiratory depression in patients. Herein, when indications are received for particular events being logged to a computerized clinical workflow, a query of patient's clinical record(s) is preformed to locate predetermined factors that are associated with medication induced respiratory depression. An overall value is calculated to stratify the possibility of adverse respiratory events for the patient. Warnings, detailed intervention instructions, and complete medical orders can be automatically generated and provided to a clinician and/or automatically input to the clinical workflow of the patient for performance.