Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: The disclosure is generally directed to systems and methods to address surfaces of a vehicle that are uncomfortable to the touch. An example method executed by a processor includes determining a surface temperature of a component of the vehicle, determining that the surface temperature exceeds a threshold surface temperature, and issuing a notification based on the surface temperature of the component exceeding the threshold surface temperature. Determining the surface temperature of the component can involve operations such as measuring the surface temperature, estimating the surface temperature, and/or predicting the surface temperature. Measuring the surface temperature can involve obtaining a temperature measurement from a thermal sensor. Estimating the surface temperature can involve operations such as evaluating a thermal image of at least a portion of the component, evaluating an ambient temperature, and/or evaluating sunlight exposure.

Abstract: A system and method for automatic generation of a data tree structure are disclosed. A database stores contract metadata associated with a plurality of contracts. The metadata includes relationship information data regarding parentage and/or child relationship between a particular contract and other contracts among the plurality of contracts. A processor operatively connects to the database via a communication network and accesses the database via the communication network to retrieve the contract metadata including the relationship information data. The processor also implements a search engine; stores the retrieved contract metadata including the relationship information data onto the search engine for creating a linkage between data points; and automatically generates, based on the created linkage between the data points, both an application programming interface (API) and a data tree structure that displays inter-dependency between two or more sets of contracts among the plurality of contracts.

Abstract: A system and method for automatic generation of a data tree structure are disclosed. A database stores contract metadata associated with a plurality of contracts. The metadata includes relationship information data regarding parentage and/or child relationship between a particular contract and other contracts among the plurality of contracts. A processor operatively connects to the database via a communication network and accesses the database via the communication network to retrieve the contract metadata including the relationship information data. The processor also implements a search engine; stores the retrieved contract metadata including the relationship information data onto the search engine for creating a linkage between data points; and automatically generates, based on the created linkage between the data points, both an application programming interface (API) and a data tree structure that displays inter-dependency between two or more sets of contracts among the plurality of contracts.

Abstract: An embodiment of the present invention is directed to a tool that captures the meaning of the agreement in an effective and efficient manner. An embodiment of the present invention is directed to a complex data rights capturing tool. The complex data rights capturing tool may enable users to select usage rights, define the asset (e.g., dataset) and define the scope of use for the defined dataset.

Abstract: An embodiment of the present invention is directed to providing market data contract analytics. The innovative system and method are directed to market data contract analytic tools that provide the ability to visualize rights an entity has licensed from various providers or sources. The market data contract analytics tools may further provide searching capabilities (e.g., full text searching, etc.), visualization of agreements the entity has signed or entered into (e.g., linkage, terms, etc.), and performing analytics on various aspects of the agreements including associated text and metadata. An embodiment of the present invention permits entities that license information to merge workflows that exist in contract negotiation, new product research, rights enforcement, tracking impact of contract changes, responses to third party audits and/or other factors and considerations.

Abstract: Provided herein are methods, compositions and kits for labeling of target proteins such as antibodies. The methods, compositions and kits are suited for labeling of such proteins that are mixed with other non-target molecules including BSA, gelatin, and other complex biological molecules.

Abstract: The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.

Abstract: The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.

Abstract: The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.

Abstract: A rolled web of cellulosic paper. The rolled web having a machine direction and a cross direction, the rolled web comprising at least two visually distinct repeating emboss patterns of machine direction oriented embossments. Each the repeating emboss pattern comprise a first region comprising a first emboss design and a first width; a second region comprising a second emboss design and a second width; and a third region disposed between and contiguous with the first and second regions, the third region comprising a third emboss design and a third width. Each of the repeating emboss patterns have a repeat pattern width, the repeat pattern width being measured in the cross direction of the rolled web, the repeat pattern width being the sum of the first, second, and third widths of the repeating emboss pattern.

Abstract: A rolled web of cellulosic paper. The rolled web having a machine direction and a cross direction, the rolled web comprising at least two visually distinct repeating emboss patterns of machine direction oriented embossments. Each the repeating emboss pattern comprise a first region comprising a first emboss design and a first width; a second region comprising a second emboss design and a second width; and a third region disposed between and contiguous with the first and second regions, the third region comprising a third emboss design and a third width. Each of the repeating emboss patterns have a repeat pattern width, the repeat pattern width being measured in the cross direction of the rolled web, the repeat pattern width being the sum of the first, second, and third widths of the repeating emboss pattern.

Abstract: The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.

Abstract: An apparatus and system are disclosed for a fingernail cleaning device. The apparatus includes a base to attach to an opening of a container, and a tube extending from inside the container through the base. The tube defines a first and a second liquid pathway. The apparatus also includes a fingernail brush coupled with the base. The fingernail brush is formed of bristles having a base end coupled to the base and a tip end distal to the base end. The first and second liquid pathways are selected in response to the position of the fingernail brush relative to the tube. The first pathway dispenses liquid at the base end of bristles and the second pathway dispenses liquid at the tip end of the bristles. The system includes the apparatus, and a flip top for enclosing the fingernail brush.