Abstract: The present invention provides methods for preselecting TILs based on PD-1, CD39, CD38, CD103, CD101, LAG3, TIM3 and/or TIGIT expression, as well as methods for expanding those preselected PD-1, CD39, CD38, CD103, CD101, LAG3, TIM3 and/or TIGIT positive TILs in order to produce therapeutic populations of TILs with enhanced tumor-specific killing capacity (e.g., enhanced cytotoxicity).

Abstract: The present invention provides methods for preselecting TILs based on PD-1 expression, as well as methods for expanding those preselected PD-1 positive TILs in order to produce therapeutic populations of TILs with enhanced tumor-specific killing capacity (e.g., enhanced cytotoxicity).

Abstract: The present disclosure provides methods for expanding TIL populations from fine needle aspirates (FNAs) or small biopsies which contain low numbers of TILs, using the methods disclosed herein including in a closed system that leads to improved phenotype and increased metabolic health of the TILs in a shorter time period.

Abstract: A bag for carrying a breast pump, related accessories and personal items is provided, comprising a plurality of interior and exterior pouches for holding various items, and a thermally-insulated interior space for housing a breast pump and collection containers. The bag has at least one handle that facilitates carrying the bag on a shoulder of a human body.

Abstract: The present disclosure provides methods for expanding TIL populations from fine needle aspirates (FN As) or small biopsies which contain low numbers of TILs, using the methods disclosed herein including in a closed system that leads to improved phenotype and increased metabolic health of the TILs in a shorter time period.

Abstract: A system with a boiler and a turbine, and an associated control method. The method includes sensing a plurality of operating conditions at a first common boiler location. At least one of the plurality of operating conditions sensed at the first common location is indicative of a combustion anomaly occurring during operation. The combustion anomaly indicated by the plurality of operating conditions at the first common location is traced back to an offending burner that is at least partially responsible for the combustion anomaly based on a model that takes into consideration at least two of the plurality of operating conditions sensed at the first common location. At least one of a process input and a boiler configuration is adjusted to establish a desired value of the operating conditions at the first common location.