Abstract: A system and method for managing patient consent. A Master Matching Index (MMI) includes a collection of patient information and identifiers. An MMI adapter is coupled to the MMI for sending queries to the MMI for a health related entity. The MMI adapter comprises a data access manager that includes a lookup module, an authorization engine, an auditing module, a report module and a user interface engine. The user profile engine generates and updates user profile information. The lookup module enables a user to query patient information. The authorization engine determines whether the user has authorization to access patient information. The auditing module logs and monitors user activity. The report module generates reports related to user activity. The user interface engine generates user interfaces for displaying the user profiles, patient profiles and patient data.