Patents by Inventor Michelle V. Letarte

Michelle V. Letarte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DIAGNOSING AND TREATING COMPLICATIONS OF PREGNANCY
    Publication number: 20170242022
    Abstract: Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin, endothelial nitric oxide synthase, PGI2, TGF-?1, TGF-?3, activin A, BMP2, BMP7, and sFlt-1 expression levels or biological activity. Also disclosed are methods of diagnosing a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, that include the measurement of any one or more of the following: soluble endoglin, endothelial nitric oxide synthase, PGI2, TGF-?1, TGF-?3, activin A, BMP2, BMP7, and sFlt-1 expression levels or biological activity.
    Type: Application
    Filed: September 28, 2016
    Publication date: August 24, 2017
    Applicants: Beth Israel Deaconess Medical Center, Inc., The Hospital for Sick Children
    Inventors: S. Ananth KARUMANCHI, Vikas P. SUKHATME, Mourad TOPORSIAN, Michelle V. LETARTE
  • Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders
    Patent number: 7740849
    Abstract: Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin and sFlt-1 expression levels or biological activity. Also disclosed are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that increase endothelial nitric oxide synthase levels or biological activity.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: June 22, 2010
    Assignees: Beth Israel Deaconess Medical Center, The Hospital for Sick Children
    Inventors: S. Ananth Karumanchi, Vikas P. Sukhatme, Mourad Toporsian, Michelle V. Letarte
  • Methods of Diagnosing and Treating Complications of Pregnancy
    Publication number: 20090286271
    Abstract: Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin, endothelial nitric oxide synthase, PGI2, TGF-?1, TGF-?3, activin A, BMP2, BMP7, and sFlt-1 expression levels or biological activity. Also disclosed are methods of diagnosing a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, that include the measurement of any one or more of the following: soluble endoglin, endothelial nitric oxide synthase, PGI2, TGF-?1, TGF-?3, activin A, BMP2, BMP7, and sFlt-1 expression levels or biological activity.
    Type: Application
    Filed: May 31, 2007
    Publication date: November 19, 2009
    Inventors: Ananth S. Karumanchi, Vikas P. Sukhatme, Mourad Toporsian, Michelle V. Letarte