Patents by Inventor Michelle ZHANG

Michelle ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TEM8 antibodies and their use in treatment and detection of tumors
    Patent number: 9765142
    Abstract: Antibodies that specifically bind TEM8 protein, conjugates thereof, and their use, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.
    Type: Grant
    Filed: October 13, 2014
    Date of Patent: September 19, 2017
    Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, Biomed Valley Discoveries, Inc.
    Inventors: Dimiter Dimitrov, Zhongyu Zhu, Brad St. Croix, Enrique Zudaire, Saurabh Saha, Xiaoyan Michelle Zhang, Gary Decrescenzo, Dean Welsch
  • LPT-723 AND IMMUNE CHECKPOINT INHIBITOR COMINATIONS AND METHODS OF TREATMENT
    Publication number: 20170007587
    Abstract: The present invention provides, inter alia, a composition containing a compound of formula (I): or a pharmaceutically acceptable salt thereof, optionally, in combination with at least one immune checkpoint inhibitor compound. Kits containing the composition, and methods of using the composition for ameliorating or treating the effects of a disease such as a cancer, in a subject, are also provided herein.
    Type: Application
    Filed: June 28, 2016
    Publication date: January 12, 2017
    Inventors: Saurabh Saha, Linping Zhang, Xiaoyan Michelle Zhang
  • TEM8 ANTIBODIES AND THEIR USE
    Publication number: 20160264662
    Abstract: Antibodies that specifically bind TEM8 protein, conjugates thereof, and their use, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.
    Type: Application
    Filed: October 13, 2014
    Publication date: September 15, 2016
    Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV, BIOMED VALLEY DISCOVERIES, INC.
    Inventors: Dimiter Dimitrov, Zhongyu Zhu, Brad St. Croix, Enrique Zudaire, Saurabh Saha, Xiaoyan Michelle Zhang, Gary Decrescenzo, Dean Welsch
  • TEM8 antibodies, conjugates thereof, and their use
    Patent number: 9181340
    Abstract: Antibodies that specifically bind TEM8 protein, and conjugates thereof, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: November 10, 2015
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Novartis AG
    Inventors: Brad St. Croix, Tony Fleming, Amit Chaudhary, Saurabh Saha, Xiaoyan Michelle Zhang, Rou-fun Kwong, Mary Beth Hilton
  • TEM8 ANTIBODIES, CONJUGATES THEREOF, AND THEIR USE
    Publication number: 20140134179
    Abstract: Antibodies that specifically bind TEM8 protein, and conjugates thereof, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.
    Type: Application
    Filed: June 13, 2012
    Publication date: May 15, 2014
    Applicants: Novartis AG, The United States of America, as represented by the Sec., Dept of Health and Human Services
    Inventors: Brad St. Croix, Tony Fleming, Amit Chaudhary, Saurabh Saha, Xiaoyan Michelle Zhang, Rou-fun Kwong
  • Methods for imperfect insulating film electrical thickness/capacitance measurement
    Patent number: 7397254
    Abstract: Methods for determining an electrical parameter of an insulating film are provided. One method includes measuring a surface potential of a leaky insulating film without inducing leakage across the insulating film and determining the electrical parameter from the surface potential. Another method includes applying an electrical field across the insulating film. Leakage across the insulating film caused by the electrical field is negligible. The method also includes measuring a surface potential of the specimen and determining a potential of the substrate. In addition, the method includes determining a pure voltage across the insulating film from the surface potential and the substrate potential. The method further includes determining the electrical parameter from the pure voltage. The electrical parameter may be capacitance or electrical thickness of the insulating film.
    Type: Grant
    Filed: March 21, 2006
    Date of Patent: July 8, 2008
    Assignee: KLA-Tencor Technologies Corp.
    Inventors: Xiafang (Michelle) Zhang, Zhiwei (Steve) Xu, Jianou Shi, Quoc-Bao Vu, Thomas G. Miller, Gregory S. Horner
  • Methods for imperfect insulating film electrical thickness/capacitance measurement
    Patent number: 7075318
    Abstract: Methods for determining an electrical parameter of an insulating film are provided. One method includes measuring a surface potential of a leaky insulating film without inducing leakage across the insulating film and determining the electrical parameter from the surface potential. Another method includes applying an electrical field across the insulating film. Leakage across the insulating film caused by the electrical field is negligible. The method also includes measuring a surface potential of the specimen and determining a potential of the substrate. In addition, the method includes determining a pure voltage across the insulating film from the surface potential and the substrate potential. The method further includes determining the electrical parameter from the pure voltage. The electrical parameter may be capacitance or electrical thickness of the insulating film.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: July 11, 2006
    Assignee: KLA-Tencor Technologies Corp.
    Inventors: Xiafang (Michelle) Zhang, Zhiwei (Steve) Xu, Jianou Shi, Bao Vu, Thomas G. Miller, Gregory S. Horner