Abstract: Various implementations include control mechanisms for managing hearing aid usage. In some cases, an interface with a representation of the hearing aid in space is used to control audio functions in the device. In other cases, directionality of the device is controlled based upon the user's visual focus direction. In additional cases, the operating mode of the device is adjustable based upon the signature of a nearby acoustic signal.

Abstract: The present disclosure describes carbamate analogs of mibefradil, as well as their compositions and methods of use. The compounds block the activity of one or more isoforms of voltage-gated calcium channels and are useful in the treatment of diseases including, e.g., cancer.

Abstract: In one embodiment, a method of generating a computer-generated reality (CGR) file includes receiving, via one or more input devices, user input generating a computer-generated reality (CGR) scene, a user input associating an anchor with the CGR scene, user input associating one or more CGR objects with the CGR scene, wherein the CGR objects are to be displayed in association with the anchor, and user input associating a behavior with the CGR scene, wherein the behavior includes one or more triggers and actions and wherein the actions are performed in response to detecting any of the triggers. The method includes generating a CGR file including data regarding the CGR scene, the CGR file including data regarding the anchor, the CGR objects, and the behavior.

Abstract: The disclosure relates to highly temperable colored glass compositions. The colored glass compositions have high coefficients of thermal expansion and high Young's moduli that advantageously absorb in the ultraviolet and/or blue wavelength ranges. Methods of making such glasses are also provided.

Abstract: In one embodiment, a humeral implant is provided that includes a hollow stem and a mounting end. The hollow stem has a sharp distal edge. The mounting end has a mounting hole and a mounting channel disposed about the mounting hole. The mounting hole is configured to receive a tapered projection of an anatomic articular body. The mounting channel is configured to receive an annular projection of a reverse articular body.

Abstract: A protective garment for selectively shielding the nipples of a nursing animal includes a sleeve that has opposing ends. The opposing ends are open, such that the sleeve is configured to position around a torso of the nursing animal with at least the nipples of the nursing animal covered by the sleeve. A plurality of holes is positioned through a bottom of the sleeve. Each hole is configured to insert a respective nipple of the nursing animal. A guard is configured to reversibly couple to the bottom of the sleeve. The guard is positioned to couple to the sleeve to cover the plurality of holes, such that the nipples positioned through the holes are shielded.

Abstract: The presently disclosed subject matter is directed to an assay that detects and quantitatively determines the activity of a lytic peptide that exhibits antimicrobial activity, such as LL-37. Particularly, the assay comprises inducing and/or transfecting bacteria to produce high levels of an enzyme, such as ?-galactosidase. The bacteria are then preserved by lyophilization. After a desired amount of time, the bacteria are hydrated with a target sample from a subject suspected of having a specific disease or disorder characterized by an increase in levels of lytic peptide. In the presence of lytic peptide, the enzyme is released from the interior of the bacteria, which can then be detected by alteration of the enzyme substrate. In the absence of lytic peptide, the enzyme remains within the bacteria and no detection of the enzyme occurs.

Abstract: The present disclosure provide viral compositions and methods for modulating adeno-associated virus properties including transduction efficiency, virus capsid assembly, viral genome packaging, capsid stability and intracellular processing. Engineered adeno-associated viruses with modifications in the N-terminal region of the capsid proteins VP1 or VP2 are provided which have varying effects on viral properties including transduction efficiency. Corresponding nucleic acids and amino acids are provided.

Abstract: Among the various aspects of the present disclosure is the provision of a method of generating a neuron. In some embodiments, the neuron is generated from an adult fibroblast cell comprising miR-9/9* and miR-124 (miR-9/9-124); and one or more transcription factors. In some embodiments, the transcription factors comprise ISL1 and LHX3 or CTIP2, DLX1, DLX2, and MYT1L (CDM).

Abstract: In one embodiment, a system includes a first object, a second object, and a latch. The latch includes a worm gear, a spur gear, and a lever arm. The spur gear rotates in response to rotating the worm gear. The lever arm rotates in response to rotating the spur gear. The first object latches to the second object in response to rotating the lever arm.

Abstract: A shelf stable hydration beverage can be prepared based on a dairy permeate.

Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo.

Abstract: A medical device is configured to produce an accelerometer signal and detect a patient fall from the accelerometer signal. The device generates a body posture signal and a body acceleration signal from the accelerometer signal and detects a patient fall in response to determining that the body posture signal and the body acceleration signal meet fall detection criteria. The medical device is configured to receive a truth signal from another device that is not the medical device. The truth signal may indicate that the detected patient fall is a falsely detected patient fall and, responsive to receiving the truth signal, the medical device adjusts at least one fall detection control parameter.

Abstract: In one aspect, the present disclosure relates to a method for crowdfunding credit card payments. The method can include: analyzing a plurality of credit card accounts to determine a first account that is eligible for crowdfunding; transmitting a notification to a user device associated with an account holder of the first account, the notification prompting the account holder to authorize enabling receipt of crowdfunded payments for the first account; receiving, from the user device, authorization to enable receipt of crowdfund payments for the first account; providing, to one or more donors, electronic access to recent transaction information for the first account; receiving a payment from a first one of the donors; and applying the payment to the first account.

Abstract: A container holder for a vehicle is disclosed. The container holder defines a central axis. The container holder includes an inner body defining an innermost surface, where the innermost surface of the container holder is shaped to receive a bottom portion of a container. The container holder also includes an iris mechanism at least partially surrounding the inner body. The iris mechanism includes a plurality of blades that expand inwardly towards the central axis of the container holder and exert a clamping force upon a container placed within the inner body of the container holder.

Abstract: In one implementation, a method of spatially manipulating a three-dimension object includes displaying a three-dimensional object in a three-dimensional space from a first virtual camera perspective, wherein the three-dimensional space is defined by a three-dimensional coordinate system including three perpendicular axes. The method includes displaying a spatial manipulation user interface element including a first set of spatial manipulation affordances respectively associated with a first set of spatial manipulations of the three-dimensional object, wherein the first set of spatial manipulations is based on the first virtual camera perspective. The method includes detecting a user input changing the first virtual camera perspective to a second virtual camera perspective.

Abstract: Method and apparatus for implementing a Blockchain that tracks a transfer of natural gas from a seller to a buyer. The Blockchain is in logical communication with Off-Block controllers and logical systems and storage. This may allow for faster reconciliation between the parties due to cuts to the natural gas transfer, as all parties can be in agreement on relevant facts to the transfer. The Blockchain may also be in logical connection with one or more pipelines involved in the transfer of gas from the seller to the buyer.

Abstract: A product identification system that reduces operator error related to scanning an incorrect barcode. The product identification system includes a generally planar substrate with a barcode disposed thereon. The substrate includes a raised section that extends out of the plane of the substrate with a portion of the barcode being disposed on the raised section such that the barcode is detectable only when a detector is properly positioned relative to the barcode. The product identification system can be used in a warehouse environment to prevent warehouse workers from scanning nearby barcodes by mistake.

Abstract: A credit score user interface that may comprise a circular visual interface to view a consumer's credit information is disclosed herein. Sections of the circular visual interface may correspond to credit categories, where each section is sized according to the impact of the associated credit category on the consumer's credit score. One of the category sections may be selected, and credit information about a specific consumer that is related to that section may be displayed. The selected credit category may change based on touch input. A change in selection may cause new credit information related to the newly selected credit category to be displayed about the specific consumer.

Abstract: Systems, methods, and devices for managing privacy policies are disclosed. In one embodiment, a method for management of a user's privacy preferences may include: identifying a computer application installed on a user electronic device, or a website accessed using a browser executed by the user electronic device; retrieving a privacy policy document analysis for a privacy policy document associated with the computer application or the website, the privacy policy document analysis comprising a valuation of a plurality of privacy policy segments within the privacy policy document; receiving a privacy preference analysis for the user, the privacy preference analysis comprising a valuation of a plurality of privacy preferences for the user; identifying a recommended action in response to the valuation of one of the privacy policy segments being outside the scope of the valuation of one of the plurality of privacy preferences; and executing the recommended action.