Patents by Inventor Michiel Christian Alexander Van Vliet
Michiel Christian Alexander Van Vliet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11944596Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.Type: GrantFiled: May 27, 2021Date of Patent: April 2, 2024Assignee: Alcresta Therapeutics, Inc.Inventors: Robert Gallotto, Greta L. Loring, Kenneth Gary, Edward S. Park, David J. Brown, Willem Robert Klaas Schoevaart, Michiel Christian Alexander van Vliet
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Publication number: 20240093250Abstract: The present invention relates to processes for preparing linkers that are useful in the conjugation of therapeutic molecules (e.g., cytotoxic agents) with targeting moieties (e.g., proteins, peptides, antibodies, nanoparticles, nucleic acids). During said processes lipases like lipase B from Candida antarctica were used for enantioselective resolution of (S,S)-2-benzylthiocyclohexanol or (S,S)-2-benzylthiocycloheptanol in presence of acylating agent which are reduced for deprotection to yield (S,S)-2-mercaptocyclohexanol or (S,S)-2-mercaptocyclopentanol which can then be used for linking therapeutic with targeting moieties.Type: ApplicationFiled: January 7, 2022Publication date: March 21, 2024Inventors: Robert John Maguire, Michiel Christian Alexander van Vliet, Willem Robert Klaas Schoevaart
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Patent number: 11911357Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.Type: GrantFiled: May 27, 2021Date of Patent: February 27, 2024Assignee: Alcresta Therapeutics, Inc.Inventors: Robert Gallotto, Greta L. Loring, Kenneth Gary, Edward S. Park, David J. Brown, Willem Robert Klaas Schoevaart, Michiel Christian Alexander van Vliet
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Publication number: 20210283085Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.Type: ApplicationFiled: May 27, 2021Publication date: September 16, 2021Applicant: Alcresta Therapeutics, Inc.Inventors: Robert GALLOTTO, Greta L. LORING, Kenneth GARY, Edward S. PARK, David J. BROWN, Willem Robert Klaas SCHOEVAART, Michiel Christian Alexander van VLIET
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Patent number: 11045440Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.Type: GrantFiled: February 27, 2019Date of Patent: June 29, 2021Assignee: Alcresta Therapeutics, Inc.Inventors: Robert Gallotto, Greta L. Loring, Kenneth Gary, Edward S. Park, David J. Brown, Willem Robert Klaas Schoevaart, Michiel Christian Alexander van Vliet
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Patent number: 10844088Abstract: The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3, 15a, 16a, 17?-tetraol (estetr-01), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10), 16-tetraene, wherein A is a protecting group and B is —Si(R2)3. The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10), 15-tetraen-17-one, in which A is a protecting group, via silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, and B is —Si(R2)3.Type: GrantFiled: February 7, 2017Date of Patent: November 24, 2020Assignee: ESTETRA SPRLInventors: Johannes Jan Platteeuw, Herman Jan Tijmen Coelingh Bennink, Franciscus Wilhelmus Petrus Damen, Michiel Christian Alexander Van Vliet
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Publication number: 20190224155Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.Type: ApplicationFiled: February 27, 2019Publication date: July 25, 2019Applicant: Alcresta Therapeutics, Inc.Inventors: Robert Gallotto, Greta L. Loring, Kenneth Gary, Edward S. Park, David J. Brown, Willem Robert Klaas Schoevaart, Michiel Christian Alexander van Vliet
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Patent number: 10258590Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.Type: GrantFiled: October 12, 2016Date of Patent: April 16, 2019Assignee: Alcresta Therapeutics, Inc.Inventors: Robert Gallotto, Greta L. Loring, Kenneth Gary, Edward S. Park, David J. Brown, Willem Robert Klaas Schoevaart, Michiel Christian Alexander van Vliet
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Publication number: 20190075835Abstract: Exemplary embodiments of the disclosure may be drawn to a device having one or more chambers. The one or more chambers may contain immobilized lipase and a phytosterol processing excipient. The device may also include an inlet fluidly connected to one of the one or more chambers, wherein the inlet is configured to receive nutritional formula into one of the one or more chambers. The device may further include an outlet through which nutritional formula is configured to flow after passing through the one or more chambers.Type: ApplicationFiled: September 6, 2018Publication date: March 14, 2019Applicant: Alcresta Therapeutics, Inc.Inventors: Eric FIRST, David Widom, Albert Archie Stone, Willem Robert Klass Schoevaart, Michiel Christian Alexander van Vliet
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Publication number: 20170369521Abstract: The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3, 15a, 16a, 1713-tetraol (estetr-01), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10), 16-tetraene, wherein A is a protecting group and B is —Si(R2)3. The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10), 15-tetraen-17-one, in which A is a protecting group, via silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, and B is —Si(R2)3.Type: ApplicationFiled: February 7, 2017Publication date: December 28, 2017Applicant: Donesta Bioscience B.V.Inventors: Johannes Jan PLATTEEUW, Herman Jan Tijmen COELINGH BENNINK, Franciscus Wilhelmus Petrus DAMEN, Michiel Christian Alexander VAN VLIET
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Publication number: 20170105903Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.Type: ApplicationFiled: October 12, 2016Publication date: April 20, 2017Applicant: ALCRESTA THERAPEUTICS, INC.Inventors: Robert GALLOTTO, Greta L. LORING, Kenneth GARY, Edward S. PARK, David J. BROWN, Willem Robert Klaas SCHOEVAART, Michiel Christian Alexander van VLIET
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Patent number: 9273333Abstract: The present invention relates to an improved process for the preparation of compound of Formula-II, which is an intermediate in the preparation of HMG-CoA reductase inhibitors. wherein X is hydrogen or hydroxy protecting group and R1 is carboxyl protecting group.Type: GrantFiled: May 28, 2014Date of Patent: March 1, 2016Assignee: Mylan Laboratories LTDInventors: Michiel Christian Alexander Van Vliet, Willem Robert Klaas Schoevaart, Madhuresh Kumar Sethi, Sanjay Mahajan, Bhairaiah Mara
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Publication number: 20140349350Abstract: The present invention relates to an improved process for the preparation of compound of Formula-II, which is an intermediate in the preparation of HMG-CoA reductase inhibitors. wherein X is hydrogen or hydroxy protecting group and R1 is carboxyl protecting group.Type: ApplicationFiled: May 28, 2014Publication date: November 27, 2014Inventors: Michiel Christian Alexander Van Vliet, Willem Robert Klass Schoevaart, Madhuresh Kumar Sethi, Sanjay Mahajan, Bhairaiah Mara
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Patent number: 7718564Abstract: The present invention is related to a hydrocarbon oxidation process. The process comprises bringing one or more hydrocarbons into contact with a source of oxygen in the presence of a radical initiator and a catalyst. The catalyst comprises an organic metal complex located on a catalyst support, and is obtained by partial decomposition of the organic metal complex. For example, the process can be used to produce dimethyl carbonate from dimethoxy methane. The invention is also related to a partially decomposed catalyst that comprises a silica support and an organic metal complex, wherein at least 5% of the organic compound remains in the catalyst. The organic metal complex comprises an organic compound and a metal-based compound wherein the metal is selected from copper, nickel, and combinations thereof.Type: GrantFiled: May 16, 2006Date of Patent: May 18, 2010Assignee: ExxonMobil Research and Engineering CompanyInventors: Jihad Mohammed Dakka, Sabato Miseo, Stuart Leon Soled, Jose Guadalupe Santiesteban, Joseph Ernest Baumgartner, Michiel Christian Alexander Van Vliet, Roger Arthur Sheldon
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Publication number: 20100036126Abstract: This invention provides for a compound according to Formula (1), wherein R1 is methyl, ethyl, n-propyl, isopropyl, benzyl or 2-haloethyl and the use thereof in a method to prepare (S)-1-methyl-3-phenylpiperazine by enzymatic hydrolysis of the compound, followed by separation and cleavage of the oxalamic groups, whereby the protease of Streptomyces griseus is used as enzyme for the enzymatic hydrolysis.Type: ApplicationFiled: June 14, 2007Publication date: February 11, 2010Applicant: N.V. OrganonInventors: Michiel Christian Alexander van Vliet, Gerardus Johannes Kemperman, Marcel Schreuder Goedheijt