Patents by Inventor Michiel E. Ultee

Michiel E. Ultee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for lyoprotecting a macromolecule using tricine
    Patent number: 5942210
    Abstract: This invention relates to lyoprotection agents for protecting macromolecules during lyophilization or freeze-drying. In particular, methods for use of these lyoprotectants in conjugate formulations are disclosed. Additionally, this invention describes lyophilized instant kit formulations for the radiolabeling of pharmaceuticals and/or macromolecules.
    Type: Grant
    Filed: November 15, 1994
    Date of Patent: August 24, 1999
    Assignee: Cytogen Corporation
    Inventors: Michiel E Ultee, Charlotte A Burton
  • Method for the preparation of antibody-fragment conjugates
    Patent number: 4937183
    Abstract: A novel method for preparing soluble antibody fragment compositions having superior characteristics for targeted delivery when administered in vivo are disclosed. The antibody fragment compositions are characterized by substantially the same immunospecificity as the unconjugated antibody and aqueous solubility such that they are suitable for in vivo administration. Therapeutic and diagnostic methods utilizing the antibody fragment compositions are also disclosed.
    Type: Grant
    Filed: February 3, 1988
    Date of Patent: June 26, 1990
    Assignee: Cytogen Corporation
    Inventors: Michiel E. Ultee, Vernon L. Alvarez
  • N,N'-bis(4-azidobenzoyl)cystine
    Patent number: 4784804
    Abstract: N,N'-Bis(4-Azidobenzoyl) Cystine useful as photoaffinity labels.
    Type: Grant
    Filed: August 4, 1986
    Date of Patent: November 15, 1988
    Assignee: New York University
    Inventors: Ross S. Basch, Michiel E. Ultee