Abstract: For the purpose of providing a particulate support capable of adsorbing a target substance highly specifically at a high density and at greatly elevated recovery efficiency, and a process of separation/purification or extraction. The particulate support is made of a carbonaceous material and/or a carbide and is for use in the separation/purification or extraction of substances related to biological organisms, while the process of separation/purification or extraction of substances related to biological organisms is conducted using the particulate support.

Abstract: For the purpose of overcoming a conventional art problem of spot detachment during the process of gene analysis (for example, hybridization) by strongly immobilizing biological material samples such as DNA or protein via covalent bonding on a substrate, the invention provides a solid support with a surface-treated layer of hafnium carbide, niob carbide, silicone carbide, tantalum carbide, thorium carbide, titanium carbide, uranium carbide, tungsten carbide or zirconium carbide as formed on the surface thereof so as to enable the immobilization of oligonucleotide or DNA fragment on the surface thereof; a solid support immobilizing oligonucleotide or DNA fragment on the film of the surface-treated layer; and a method for analyzing gene by immobilizing gene on the surface of such solid support.

Abstract: A support for fixing a nucleotide which contributes to the efficient clarification of DNA without damaging the terminal parts of the DNA and, therefore, is useful in the fields of biology, biochemistry and the like. This support for fixing a nucleotide is a chemically modified substrate on which oligonucleotide are immobilized characterized in that the oligonucleotide have a restriction enzyme cleavage site. This support is produced by chemically modifying the substrate, immobilizing a single-stranded oligonucleotide thereon, then hybridizing the single-stranded oligonucleotide with another single-stranded oligonucleotide having a base sequence complementary thereto, and ligating an oligonucleotide having a restriction enzyme site at the end thereof.

Abstract: A subject of the present invention is to provide a support with immobilized DNA as a DNA library and particularly to a support suitable for reproducing DNA in accordance with a DNA amplification reaction. In the present invention, DNA or the like is immobilized on a surface of a support made of one kind or more than material Selected from a group of a diamond including non-diamond carbon, amorphous carbon and graphite. A hydroxyl group may be bonded to a surface of the support or a group bonded to a hydrocarbon group and a carboxyl group at its terminal end may be bonded to a surface of the support through an ester linkage or a peptide linkage.

Abstract: A microchip for chemical reaction capable of rapidly performing an experiment irrespective of the types of the chemical substrates used for the experiment under various experimental conditions, wherein a horizontal communication path 13 comprising a plurality of chemical reaction pool portions 11, 12 and grooves communicating these chemical reaction pool portions 11, 12 to each other is formed in the surface of a diamond substrate 10 of minute size forming a substrate, a vertical communication path 20 comprising through-holes vertically communicating the chemical reaction pool portions 11, 12 to each other is provided in the diamond substrate 10, and an opening/closing valve 21 is installed at a communicating portion, and further heating/cooling portions 23, 24 such as a Peltier device are installed at those positions corresponding to the chemical reaction pool portions 11, 12, respectively, whereby a variety of experiments can be performed in a very small space without being restricted by the types of chemic

Abstract: A purpose of the present invention is to provide a gene amplification apparatus with simple operation, wherein the apparatus can heat and cool gene rapidly and a thermal cycle can be operated in a relatively short period and a method thereof, a method for preparing immobilized DNA library suitable to the above apparatus and a method for comparing genes systematically. The apparatus for preparing immobilized DNA library according to the present invention comprises a reaction body 10 on which a grooved portion for receiving a container is formed, a cap portion 50 provided at an upper portion of the reaction body and a container 12 formed by substrates for immobilizing DNA, wherein the cap portion 50 including means for heating/cooling 51 and means for cooling 52.

Abstract: Articles with a tenaciously adherent diamond coating are made by forming a diamond coating on a base material by vapor-phase synthesis without causing any warpage of the coating. The diamond coating layer is formed on the surface of a base material having a number of pores formed by electric discharge or laser beams and having a depth of 0.0001-0.2 mm and a diameter of 0.001-0.02 mm. The pores may be connected to one another to form a groove. Suitable examples of the base material include molybdenum, tungsten, silicon, tungsten carbide, silicon carbide, silicon nitride, and cemented carbide mainly comprising tungsten carbide and cobalt and/or nickel.

Abstract: A method for removing polymer scales adhering to the inner surface of a polymerization vessel, which comprises polymerizing vinyl chloride monomer in an aqueous medium, discharging the resulting vinyl chloride polymer together with the aqueous medium from the polymerization vessel, thereafter placing in the vessel both a reaction product resulting from the reaction of an amine and acrylic acid or its derivative and an organic liquid which can dissolve or swell the polyvinyl polymer, and washing the inner surface of the vessel with the organic liquid solution of the reaction product.

Abstract: The formation of scale on the inner surfaces of a vessel used for suspension polymerizing vinyl chloride is inhibited by applying a ternary reaction product of furfural, a polyamine and a phenol to said inner surfaces or by adding the ternary product to the polymerization system.

Abstract: A method for preparing foams of chlorinated vinyl chloride polymers is provided. The foams are prepared by impregnating the chlorinated vinyl chloride polymer with an aliphatic alcohol of from 1 to 5 carbon atoms and thereafter heating the impregnated polymer.