Patents by Inventor Michiharu HANDA
Michiharu HANDA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220372069Abstract: An object of the present invention is to provide a method for producing a peptide with high efficiency, and a method for producing a peptide which comprises the following steps (1) and (2): (1) a step of mixing an N-protected amino acid or an N-protected peptide with a carboxylic acid halide represented by the formula (I) (wherein X represents a halogen atom, R1, R2 and R3 each independently represent an aliphatic hydrocarbon group which may have a substituent, and a total number of the carbon atoms in R1, R2 and R3 is 3 to 40); and (2) a step of mixing the product obtained in the step (1) and a C-protected amino acid or a C-protected peptide is provided.Type: ApplicationFiled: September 14, 2020Publication date: November 24, 2022Applicants: NISSAN CHEMICAL CORPORATION, PEPTIDREAM INC.Inventors: Keisuke MORODOME, Michiharu HANDA
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Publication number: 20220306682Abstract: The invention provides a method for producing a peptide by (1) removing the N-terminal protective group of an amino acid or peptide compound of formula (I): wherein Y represents a residue of an N-protected amino acid or an N-protected peptide, and each of R1, R2, and R3 independently represents an aliphatic hydrocarbon group which may have a substituent or an aromatic hydrocarbon group which may have a substituent, wherein the total number of carbon atoms in the R1R2R3Si group is 18 to 80, and the R1R2R3SiCH2CH2 group is bonded to the C-terminus of the amino acid or peptide residue in Y; and (2) causing condensation of an N-protected amino acid or an N-protected peptide and the N-terminus of the C-protected amino acid or C-protected peptide obtained in the step (1).Type: ApplicationFiled: August 27, 2020Publication date: September 29, 2022Applicant: NISSAN CHEMICAL CORPORATIONInventors: Akihiro NAGAYA, Michiharu HANDA, Yuji MIMORI
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Publication number: 20220204550Abstract: The invention provides a method for producing a peptide which includes a step of reacting a peptide in which a C-terminal carboxy group is activated which is obtained by reacting an N-protected peptide represented by the formula (I): P-AA1-OH??(I) a tertiary amine represented by the formula (II): and an acid halide in a flow reactor, with a silylated amino acid or peptide obtained by reacting an amino acid or peptide represented by the formula (III): H-AA2-OH??(III) with a silylating agent, in a flow reactor, wherein, in the formulae (I) to (III), AA1, AA2, P, R1, R2 and R3 are as defined herein.Type: ApplicationFiled: April 23, 2020Publication date: June 30, 2022Applicant: NISSAN CHEMICAL CORPORATIONInventors: Michiharu HANDA, Shota MURASE
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Publication number: 20220153777Abstract: The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl formate; Step (2): a step of mixing an amino acid or a peptide in which the N-terminal and the C-terminal are not protected with a trialkylsilylating agent; and Step (3): a step of mixing the product obtained in Step (1) with the product obtained in Step (2).Type: ApplicationFiled: March 16, 2020Publication date: May 19, 2022Applicants: NISSAN CHEMICAL CORPORATION, PeptiDream Inc.Inventors: Hisayuki TAKEUCHI, Yukio ASAKA, Akihiro NAGAYA, Michiharu HANDA, Keiichi MASUYA, Tomonori TAGURI, Yoshitaka NEMOTO, Yutaka KOBAYASHI, Ayumu MATSUDA, Haruaki KURASAKI, Douglas Robert CARY
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Publication number: 20220106355Abstract: The invention provides a method for producing a peptide which comprises the following steps (1) and (2): (1) a step of condensing a C-protected amino acid or a C-protected peptide to a C-terminal of an N-protected amino acid or an N-protected peptide represented by the formula (I): wherein Y represents an amino acid in which a C-terminal is unprotected or a peptide in which a C-terminal is unprotected, R1, R2 and R3 each independently represent an aliphatic hydrocarbon group which may have a substituent(s), a total number of the carbon atoms in the R1R2R3Si group is 10 or more, and the R1R2R3SiOC(O) group is bonded to the N-terminal in Y, and (2) a step of removing the protective group at the C-terminal of the peptide obtained in step (1).Type: ApplicationFiled: February 3, 2020Publication date: April 7, 2022Applicants: NISSAN CHEMICAL CORPORATION, PeptiDream Inc.Inventors: Michiharu HANDA, Naohiko YASUDA, Akihiro NAGAYA, Hiroyuki KOUSAKA
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Publication number: 20200291061Abstract: A method for producing a peptide by conducting steps (1) condensing an N-protected amino acid or an N-protected peptide to an N-terminus of a C-protected amino acid or a C-protected peptide represented by formula (II): wherein Y represents an amino acid or a peptide with an unprotected N-terminus; R1, R2 and R3 each independently represent an optionally substituted aliphatic hydrocarbon group, an optionally substituted aromatic hydrocarbon group, or —OR4 (wherein R4 represents an optionally substituted aliphatic or aromatic hydrocarbon group; two of R1, R2 and R3 may form a 5- to 7-membered ring together with the Si atom to which they are bonded; and the R1R2R3Si group has 8 or more carbon atoms and is bonded to a C-terminus of an amino acid or a peptide in Y, and (2) removing the protective group at the N-terminus of the peptide obtained in step (1).Type: ApplicationFiled: October 3, 2018Publication date: September 17, 2020Applicants: NISSAN CHEMICAL CORPORATION, PeptiDream Inc.Inventors: Akihiro NAGAYA, Michiharu HANDA, Naohiko YASUDA, Madoka YOSHINO, Yutaka KOBAYASHI, Keiichi MASUYA
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Patent number: 9242950Abstract: A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z1 is wherein R3 is a protecting group for a hydroxy group; which includes the step of reacting a compound of formula (II): wherein Z2 is the same as Z1 except for when Z1 is Z2 is with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.Type: GrantFiled: June 29, 2012Date of Patent: January 26, 2016Assignees: R-TECH UENO, LTD., SUCAMPO AGInventors: Tatsuya Matsukawa, Noriyuki Yamamoto, Ryuji Ueno, Hiroyuki Kotajima, Shunsuke Fukuya, Michiharu Handa, Katsuya Sakata
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Publication number: 20130005995Abstract: A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z1 is wherein R3 is a protecting group for a hydroxy group; which includes the step of reacting a compound of formula (II): wherein Z2 is the same as Z1 except for when Z1 is Z2 is with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.Type: ApplicationFiled: June 29, 2012Publication date: January 3, 2013Applicants: SUCAMPO AG, R-TECH UENO, LTD.Inventors: Tatsuya MATSUKAWA, Noriyuki YAMAMOTO, Ryuji UENO, Hiroyuki KOTAJIMA, Shunsuke FUKUYA, Michiharu HANDA, Katsuya SAKATA