Abstract: Local image enhancement processing is executed on an image obtained by imaging a transcription material. The enhanced image is divided into a plurality of patch images and input to a machine learning identifier. The patch images after segmentation output from the machine learning identifier are combined to generate a likelihood map image of skin ridges from the whole image based on a result of the segmentation. Binarization processing is executed on the likelihood map image to generate a binary image. A skin ridge region is extracted based on the binary image to calculate the area of the skin ridge region.

Abstract: Provided include a human IgE antibody that binds to a sweat allergy antigen protein and a human high-affinity IgE receptor but does not induce degranulation in a reaction with the sweat allergy antigen protein, and a composition for treatment or diagnosis of sweat allergy comprising the same.

Abstract: Provided are a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.

Abstract: Provided are a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.

Abstract: Provided are a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.

Abstract: Provided arc a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.

Abstract: Provided include a human IgE antibody that binds to a sweat allergy antigen protein and a human high-affinity IgE receptor but does not induce degranulation in a reaction with the sweat allergy antigen protein, and a composition for treatment or diagnosis of sweat allergy comprising the same.

Abstract: The invention relates to an antibody that inhibits histamine releasing activity induced by an antigenic substance contained in sweat. The invention further relates to an antibody which can react with a sweat antigen composition and inhibit the histamine releasing activity of the composition on a sweat antigen stimulation-responsive cell.

Abstract: The present invention relates to a mouse epithelial cell line constantly producing TSLP and use thereof. More specifically, the present invention relates to a method for screening for a TSLP modulator using a mouse epithelial cell line (KCHM-1) constantly producing TSLP, and a method for producing wild-type TSLP using the cell line.

Abstract: An atopic dermatitis inducer binding to a human own IgE antibody and activating mast cells and basophiles, which includes a purified human secretion fraction, or an antigenic molecule or an antigenic determinant in the purified fraction, and obtained through the following steps of: filtering a human secretion, removing insoluble matters and collecting the filtrate; mixing the filtrate with a ConA-affinity carrier and collecting the supernatant; and separating a component having a histamine-releasing activity from the supernatant by column chromatography. This inducer is effective in diagnosing and treating human atopic dermatitis.

Abstract: [Object of the Invention] To provide an antibody that inhibits histamine releasing activity induced by an antigenic substance contained in sweat. [Means for Attaining the Object] An antibody which can react with a sweat antigen composition and inhibit the histamine releasing activity of the composition on a sweat antigen stimulation-responsive cell.

Abstract: An atopic dermatitis inducer binding to a human own IgE antibody and activating mast cells and basophiles, which includes a purified human secretion fraction, or an antigenic molecule or an antigenic determinant in the purified fraction, and obtained through the following steps of: filtering a human secretion, removing insoluble matters and collecting the filtrate; mixing the filtrate with a ConA-affinity carrier and collecting the supernatant; and separating a component having a histamine-releasing activity from the supernatant by column chromatography. This inducer is effective in diagnosing and treating human atopic dermatitis.

Abstract: The invention provides a method for evaluating the physiological activity of an external stimulus on living cells by means of a surface plasma resonance analyzer, which comprises evaluating the physiological activity of the external stimulus on the cells with an indication of a secondary signal appearing after a primary signal upon the exposure of the living cells to the external stimulus. According to the invention, the level of the physiological activity of an external stimulus on living cells can be evaluated accurately.

Abstract: An agent for improving allergic predisposition is provided. This agent is effective in improving the allergic predisposition, safe, and readily ingestible. More specifically, an agent for improving allergic predisposition and an agent for suppressing production of IgE antibody containing a hydrolysate of water-soluble dietary fibers as its effective component are provided.

Abstract: An atopic dermatitis inducer binding to a human own IgE antibody and activating mast cells and basophiles, which includes a purified human secretion fraction, or an antigenic molecule or an antigenic determinant in the purified fraction, and obtained through the following steps of: filtering a human secretion, removing insoluble matters and collecting the filtrate; mixing the filtrate with a ConA-affinity carrier and collecting the supernatant; and separating a component having a histamine-releasing activity from the supernatant by column chromatography. This inducer is effective in diagnosing and treating human atopic dermatitis.

Abstract: The invention provides a method for evaluating the physiological activity of an external stimulus on living cells by means of a surface plasma resonance analyzer, which comprises evaluating the physiological activity of the external stimulus on the cells with an indication of a secondary signal appearing after a primary signal upon the exposure of the living cells to the external stimulus. According to the invention, the level of the physiological activity of an external stimulus on living cells can be evaluated accurately.