Patents by Inventor Michiie Sakamoto

Michiie Sakamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10928620
    Abstract: A microscope system includes an observation optical system including an objective lens, an XY stage capable of moving an XY plane in an X-axis direction and an Y-axis direction, a first change unit configured to change a slant of the XY plane with respect to an optical axis direction of the objective lens, and a second change unit configured to change a slant of a slide placed on the XY stage with respect to the XY plane. Changing the slant of the XY plane by the first change unit is performed based on a first mark arranged on the XY plane at a position observable by the observation optical system. Changing the slant of the slide with respect to the XY plane by the second change unit is performed based on a second mark arranged on the slide.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: February 23, 2021
    Assignee: Canon Kabushiki Kaisha
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Tsutomu Shimada, Hirotake Ando, Kazuhiko Kato
  • Patent number: 10838187
    Abstract: A slide used for observation by a microscope includes a label area configured to arrange a label, a cover glass area configured to arrange an observation object and a cover glass, a position reference mark arranged in a vacant area between the label area and the cover glass area and configured to specify a reference position of the slide and an X-axis direction and a Y-axis direction that are orthogonal to each other, and focus reference marks in which a predetermined pattern is repetitively arranged along two opposing sides of four sides of a periphery of the cover glass area, the focus reference marks being configured to specify a Z-axis direction orthogonal to the X-axis direction and the Y-axis direction.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: November 17, 2020
    Assignee: Canon Kabushiki Kaisha
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Tsutomu Shimada, Akihiro Sakai, Kazuhiko Kato
  • Patent number: 10732397
    Abstract: A microscope system comprises a microscope body, an imaging unit connected to the microscope body and including an image sensor for capturing a microscopic image, and an XY stage configured to place a slide and move in an X direction and a Y direction. The microscope system changes an arrangement of the image sensor with respect to the microscope body so as to cause a direction defined by a pixel arrangement of the image sensor to align with one of the X direction and the Y direction of the XY stage.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: August 4, 2020
    Assignee: Canon Kabushiki Kaisha
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Osamu Nagatsuka, Koichiro Nishikawa
  • Patent number: 10725309
    Abstract: A microscope system includes a microscope body, an XY stage mounted on the microscope body and including a stage configured to place a slide as an observation target and move in an X-axis direction and a Y-axis direction perpendicular to each other, and an XY two-dimensional scale plate fixed to the stage. The XY two-dimensional scale plate is provided with a first mark that provides axis information in the X-axis direction throughout a movable range of the stage in the Y-axis direction and a second mark that provides axis information in the Y-axis direction throughout a movable range of the stage in the X-axis direction, which are used to recognize X- and Y-coordinates of the stage.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: July 28, 2020
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Masahide Hasegawa, Masahiro Ando, Osamu Nagatsuka
  • Publication number: 20200159000
    Abstract: A microscope system comprises a microscope body, a stage configured to place a slide as an observation target and move in an X direction and a Y direction. The microscope system changes an arrangement of the placed slide with respect to the stage so as to cause a direction indicated by a mark provided on the slide placed on the stage to align with one of the X direction and the Y direction of the stage.
    Type: Application
    Filed: November 23, 2019
    Publication date: May 21, 2020
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Masahide Hasegawa, Osamu Nagatsuka, Koichiro Nishikawa
  • Patent number: 10634897
    Abstract: A microscope system comprises a microscope body, an image sensor mounted on the microscope body, and a stage that moves in an X-axis direction and a Y-axis direction, and places a slide as an observation object. The stage includes a mark used to indicate a stage reference position. The microscope system obtains positions of the stage in the X-axis direction and the Y-axis direction, and detects the stage reference position indicated by a mark provided on the stage and a slide reference position indicated by a mark provided on a slide placed on the stage. The microscope system manages the position of the stage by coordinates based on the slide reference position if the slide reference position is detected, and manages the position of the stage by coordinates based on the stage reference position if the slide reference position is not detected.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: April 28, 2020
    Assignee: Canon Kabushiki Kaisha
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Masahide Hasegawa, Masahiro Ando, Osamu Nagatsuka, Koichiro Nishikawa
  • Patent number: 10527836
    Abstract: A microscope system comprises a microscope body, a stage configured to place a slide as an observation target and move in an X direction and a Y direction. The microscope system changes an arrangement of the placed slide with respect to the stage so as to cause a direction indicated by a mark provided on the slide placed on the stage to align with one of the X direction and the Y direction of the stage.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: January 7, 2020
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Masahide Hasegawa, Osamu Nagatsuka, Koichiro Nishikawa
  • Publication number: 20180373015
    Abstract: A microscope system includes an observation optical system including an objective lens, an imaging unit configured to capture an image of an observation object obtained by the observation optical system, and a stage movable in an X-axis direction, a Y-axis direction, and a Z-axis direction, on which a slide of the observation object is placed. The microscope system obtains position information defined by the X-axis direction, the Y-axis direction, and the Z-axis direction, and stores the obtained position information and the image of the observation object obtained by capturing the observation object by the imaging unit in a storage in association with each other.
    Type: Application
    Filed: December 7, 2016
    Publication date: December 27, 2018
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Akihiro Sakai, Hirotake Ando, Kazuhiko Kato
  • Publication number: 20180373014
    Abstract: A slide used for observation by a microscope includes a label area configured to arrange a label, a cover glass area configured to arrange an observation object and a cover glass, a position reference mark arranged in a vacant area between the label area and the cover glass area and configured to specify a reference position of the slide and an X-axis direction and a Y-axis direction that are orthogonal to each other, and focus reference marks in which a predetermined pattern is repetitively arranged along two opposing sides of four sides of a periphery of the cover glass area, the focus reference marks being configured to specify a Z-axis direction orthogonal to the X-axis direction and the Y-axis direction.
    Type: Application
    Filed: December 7, 2016
    Publication date: December 27, 2018
    Inventors: Michiie SAKAMOTO, Akinori HASHIGUCHI, Shinobu MASUDA, Tsuguhide SAKATA, Tsutomu SHIMADA, Akihiro SAKAI, Kazuhiko KATO
  • Publication number: 20180364469
    Abstract: A microscope system includes an observation optical system including an objective lens, an XY stage capable of moving an XY plane in an X-axis direction and an Y-axis direction, a first change unit configured to change a slant of the XY plane with respect to an optical axis direction of the objective lens, and a second change unit configured to change a slant of a slide placed on the XY stage with respect to the XY plane. Changing the slant of the XY plane by the first change unit is performed based on a first mark arranged on the XY plane at a position observable by the observation optical system. Changing the slant of the slide with respect to the XY plane by the second change unit is performed based on a second mark arranged on the slide.
    Type: Application
    Filed: December 7, 2016
    Publication date: December 20, 2018
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Tsutomu Shimada, Hirotake Ando, Kazuhiko Kato
  • Publication number: 20180348497
    Abstract: A microscope system includes a microscope body, a camera connected to an observation optical system of the microscope body, and an XY stage on which a slide of an observation object is placed and which is configured to move in an X-axis direction and a Y-axis direction that are orthogonal to each other. The XY stage includes an XY two-dimensional scale plate. The XY two-dimensional scale plate includes a first mark configured to provide X-axis direction axis information and Y-axis direction axis information of the stage, and a second mark which is provided within an observable region of the camera on the same plane as the first mark and which is available for recognizing a position of an XY plane of the first mark in a Z-axis direction at each of a plurality of points by focus detection of the camera.
    Type: Application
    Filed: December 7, 2016
    Publication date: December 6, 2018
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Tsutomu Shimada, Hirotake Ando, Akihiro Sakai
  • Publication number: 20180267288
    Abstract: A microscope system comprises a microscope body, an image sensor mounted on the microscope body via mounting means and configured to capture an observation image under a microscope, and a stage that moves in an X-axis direction and a Y-axis direction, which are orthogonal to each other, and places a slide as an observation object and includes a mark used to indicate a stage reference position. The microscope system obtains positions of the stage in the X-axis direction and the Y-axis direction, and detects, from an image captured by the image sensor, the stage reference position indicated by a mark provided on the stage and a slide reference position indicated by a mark provided on a slide placed on the stage. The microscope system manages the position of the stage by coordinates based on the slide reference position if the slide reference position is detected, and manages the position of the stage by coordinates based on the stage reference position if the slide reference position is not detected.
    Type: Application
    Filed: December 8, 2015
    Publication date: September 20, 2018
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Masahide Hasegawa, Masahiro Ando, Osamu Nagatsuka, Koichiro Nishikawa
  • Patent number: 9916658
    Abstract: An image acquisition unit (2020) acquires an analysis image. The analysis image is an image in which a plurality of cell nuclei in a lesion of a target person are captured. A feature-value calculation unit (2040) calculates the feature-value relating to the cell nuclei from the analysis image. An evaluation function acquisition unit (2060) acquires an evaluation function from an evaluation function storage unit (10). The evaluation function is a function with which prediction information is calculated based on the feature-value. The prediction information generation unit (2080) generates prediction information relating to a target person based on a feature-value, which has been calculated from an analysis image, and an evaluation function which has been acquired by the evaluation function acquisition unit (2060). The prediction information is information indicating a prediction of a prognosis of a disease of the target person or a prediction of malignancy of a disease of the target person.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: March 13, 2018
    Assignees: Keio University, NEC Corporation
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Ken Yamazaki, Tokiya Abe, Akira Saito, Tomoharu Kiyuna
  • Publication number: 20170329118
    Abstract: A microscope system comprises a microscope body, a stage configured to place a slide as an observation target and move in an X direction and a Y direction. The microscope system changes an arrangement of the placed slide with respect to the stage so as to cause a direction indicated by a mark provided on the slide placed on the stage to align with one of the X direction and the Y direction of the stage.
    Type: Application
    Filed: December 8, 2015
    Publication date: November 16, 2017
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Masahide Hasegawa, Osamu Nagatsuka, Koichiro Nishikawa
  • Publication number: 20170329123
    Abstract: A microscope system comprises a microscope body, an imaging unit connected to the microscope body and including an image sensor for capturing a microscopic image, and an XY stage configured to place a slide and move in an X direction and a Y direction. The microscope system changes an arrangement of the image sensor with respect to the microscope body so as to cause a direction defined by a pixel arrangement of the image sensor to align with one of the X direction and the Y direction of the XY stage.
    Type: Application
    Filed: December 8, 2015
    Publication date: November 16, 2017
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Osamu Nagatsuka, Koichiro Nishikawa
  • Publication number: 20170269346
    Abstract: A microscope system includes a microscope body, an XY stage mounted on the microscope body and including a stage configured to place a slide as an observation target and move in an X-axis direction and a Y-axis direction perpendicular to each other, and an XY two-dimensional scale plate fixed to the stage. The XY two-dimensional scale plate is provided with a first mark that provides axis information in the X-axis direction throughout a movable range of the stage in the Y-axis direction and a second mark that provides axis information in the Y-axis direction throughout a movable range of the stage in the X-axis direction, which are used to recognize X- and Y-coordinates of the stage.
    Type: Application
    Filed: December 8, 2015
    Publication date: September 21, 2017
    Applicant: Canon Kabushiki Kaisha
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Shinobu Masuda, Tsuguhide Sakata, Masahide Hasegawa, Masahiro Ando, Osamu Nagatsuka
  • Publication number: 20170261737
    Abstract: A slide on which an observation object by a microscope is placed, is provided. A first mark indicating a reference line along a first direction and a second mark indicating a specific position on an extension of the reference line along the first direction are separately arranged in a vacant area between a label area used to arrange a label and a cover glass area used to arrange the observation object and a cover glass. A position reference is provided by the specific position on the extension of the reference line along the first direction.
    Type: Application
    Filed: December 8, 2015
    Publication date: September 14, 2017
    Inventors: Michiie SAKAMOTO, Akinori HASHIGUCHI, Shinobu MASUDA, Tsuguhide SAKATA, Koichiro NISHIKAWA
  • Publication number: 20160232665
    Abstract: An image acquisition unit (2020) acquires an analysis image. The analysis image is an image in which a plurality of cell nuclei in a lesion of a target person are captured. A feature-value calculation unit (2040) calculates the feature-value relating to the cell nuclei from the analysis image. An evaluation function acquisition unit (2060) acquires an evaluation function from an evaluation function storage unit (10). The evaluation function is a function with which prediction information is calculated based on the feature-value. The prediction information generation unit (2080) generates prediction information relating to a target person based on a feature-value, which has been calculated from an analysis image, and an evaluation function which has been acquired by the evaluation function acquisition unit (2060). The prediction information is information indicating a prediction of a prognosis of a disease of the target person or a prediction of malignancy of a disease of the target person.
    Type: Application
    Filed: August 15, 2014
    Publication date: August 11, 2016
    Applicants: NEC CORPORATION, KEIO UNIVERSITY
    Inventors: Michiie SAKAMOTO, Akinori HASHIGUCHI, Ken YAMAZAKI, Tokiya ABE, Akira SAITO, Tomoharu KIYUNA
  • Patent number: 9286670
    Abstract: A pathological diagnosis assisting apparatus according to the present invention provides the diagnosis assisting information for assisting diagnosis of tissue fibrosis from the image of the stained sample, and includes an image reading unit configured to read the image of the stained sample and an image processing unit configured to process the image. The image processing unit includes an image classification unit configured to classify the collagenous fiber and the elastic fiber, a tissue area extraction unit configured to extract a tissue area, an occupancy rate calculation unit configured to calculate the occupancy rates of the collagenous fiber and the elastic fiber in the tissue area, and a diagnosis assisting information providing unit configured to provide the diagnosis assisting information based on the calculated occupancy rates of the collagenous fiber and the elastic fiber.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: March 15, 2016
    Assignees: KEIO UNIVERSITY, NEC CORPORATION
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Tokiya Abe, Akira Saito, Maki Sano
  • Patent number: 9224199
    Abstract: A pathological diagnosis assisting apparatus according to the present invention includes an image classification unit configured to classify at least one type of a specific substance, a tissue area extraction unit configured to extract a tissue area in the image of the sample, an image dividing unit configured to divide the tissue area into a plurality of sections, a specific substance occupancy rate calculation unit configured to, calculate an occupancy rate of the at least one type of the specific substance in each of the plurality of sections, and a diagnosis assisting information providing unit configured to determine an intermediate value of the occupancy rate of the specific substance from the calculated occupancy rates of the plurality of sections and to provide the intermediate value as the diagnosis assisting information.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: December 29, 2015
    Assignees: KEIO UNIVERSITY, NEC CORPORATION
    Inventors: Michiie Sakamoto, Akinori Hashiguchi, Tokiya Abe, Akira Saito, Maki Sano