Patents by Inventor Michiko Hori

Michiko Hori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptide having thrombin inhibiting activity
    Patent number: 5166318
    Abstract: Modified HV1-type hirudinin which valine at the N-terminal end of the HV1-type hirudin and aspartic acid at the 5th residue of the N-terminal end were replaced with alanine and glutamic acid, respectively. A secretion plasmid into which a DNA sequence coding for a precursor with an addition of a secretion signal of neutral protease of Bacillus amyloliquefaciens at the N-terminal end of this modified HV1-type hirudin is integrated is introduced into bacteria of the genus Bacillus and the precursor is expressed intracellularly. The modified HV1-type hirudin can be efficiently secreted extracellularly while maintaining its high thrombin inhibiting activity.
    Type: Grant
    Filed: June 4, 1990
    Date of Patent: November 24, 1992
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Yoshio Furutani, Masaru Honjo, Akira Nakayama, Koichi Kawamura, Kazunori Ando, Michiko Hori, Keiko Fukazawa