Abstract: The present invention provides a method for producing purified platelets from a culture of megakaryocytes, comprising a first centrifugal separation step of centrifugally separating the culture at a centrifugal force of 150×g to 550×g, and a second centrifugal separation step of centrifugally separating, at a centrifugal force of 600×g to 4000×g, a liquid component recovered in the first centrifugal separation step.

Abstract: The present invention provides a method for producing purified platelets from a culture of megakaryocytes, comprising a first centrifugal separation step of centrifugally separating the culture at a centrifugal force of 150×g to 550×g, and a second centrifugal separation step of centrifugally separating, at a centrifugal force of 600×g to 4000×g, a liquid component recovered in the first centrifugal separation step.

Abstract: Separation apparatus capable of separating plasma into high molecular weight substances and low molecular weight substances containing albumin, regardless of whether plasma is obtained by separation of corpuscular components in a continuous centrifugal separator or in a batch-type centrifugal separator. The apparatus comprises a filtration membrane module, a plasma feeding circuit connecting the centrifugal separator with the filtration membrane module, a plasma return circuit for returning to a patient purified plasma freed of high molecular weight substances, a supplemental fluid circuit for supplying additional fluid to the plasma return circuit, and a condensed plasma discharge circuit for disposal of high molecular weight substances. The apparatus is controlled independently of the centrifugal separator.