Patents by Inventor Michio Hirano

Michio Hirano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12251392
    Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Grant
    Filed: April 24, 2023
    Date of Patent: March 18, 2025
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Michio Hirano, Caterina Garone, Ramon Marti
  • Publication number: 20230277577
    Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Application
    Filed: April 24, 2023
    Publication date: September 7, 2023
    Inventors: Michio Hirano, Caterina Garone, Ramon Marti
  • Patent number: 11666592
    Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: June 6, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Michio Hirano, Caterina Garone, Ramon Marti
  • Patent number: 11633418
    Abstract: The invention relates generally to a pharmacological therapy for a human genetic diseases, specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxyribonucleoside monophosphate, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine monophosphate (dTMP) or deoxycytidine monophosphate (dCMP), or mixtures thereof. This molecular bypass approach is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: April 25, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY
    Inventors: Michio Hirano, Caterina Garone
  • Patent number: 11110111
    Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: September 7, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Michio Hirano, Caterina Garone, Ramon Marti
  • Publication number: 20210252034
    Abstract: The invention relates generally to a pharmacological therapy for a human genetic diseases, specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxyribonucleoside monophosphate, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine monophosphate (dTMP) or deoxycytidine monophosphate (dCMP), or mixtures thereof. This molecular bypass approach is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Application
    Filed: April 28, 2021
    Publication date: August 19, 2021
    Inventors: Michio Hirano, Caterina Garone
  • Publication number: 20210244754
    Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Application
    Filed: April 28, 2021
    Publication date: August 12, 2021
    Inventors: Michio Hirano, Caterina Garone, Ramon Marti
  • Publication number: 20210100917
    Abstract: The invention relates generally to a method of treatment for a human genetic disease, such as diseases characterized by unbalanced nucleotide pools, e.g., mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency, using gene therapy. The gene therapy may involve administration of one or more constructs, such as a viral vector, containing a nucleic acid encoding a functional protein. The functional protein may correspond to a nuclear gene. For treatment of TK2 deficiency, the gene therapy may involve administration of one or more constructs, such as a viral vector, containing a nucleic acid encoding a functional TK2 enzyme. The treatment may also involve the administration of pharmacological therapy in conjunction with the gene therapy.
    Type: Application
    Filed: April 18, 2019
    Publication date: April 8, 2021
    Inventors: Michio Hirano, Hasan O. Akman, Carlos Lopez-Gomez
  • Publication number: 20200038424
    Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Application
    Filed: September 26, 2019
    Publication date: February 6, 2020
    Inventors: Michio Hirano, Caterina Garone, Ramon Marti
  • Patent number: 10471087
    Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: November 12, 2019
    Assignees: The Trustees of Columbia University in the City of New York, Fundació Hospital Universitari Vall d'Hebron-Institut de Recerca
    Inventors: Michio Hirano, Caterina Garone, Ramon Marti
  • Publication number: 20190282599
    Abstract: The invention relates generally to a pharmacological therapy for a human genetic diseases, specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxyribonucleoside monophosphate, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine monophosphate (dTMP) or deoxycytidine monophosphate (dCMP), or mixtures thereof. This molecular bypass approach is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Application
    Filed: April 17, 2019
    Publication date: September 19, 2019
    Inventors: Michio Hirano, Caterina Garone
  • Patent number: 10292996
    Abstract: The present invention provides a pharmacological therapy using deoxyribonucleoside monophosphate compounds, or mixtures thereof, for the treatment of human genetic diseases. The compounds of the present invention can be used to treat mitochondrial DNA depletion syndromes or other disorders of unbalanced nucleotide pools, such as thymidine kinase 2 (TK2) deficiency.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: May 21, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Michio Hirano, Caterina Garone
  • Publication number: 20180133241
    Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Application
    Filed: June 17, 2016
    Publication date: May 17, 2018
    Inventors: Michio Hirano, Caterina Garone, Ramon Marti
  • Publication number: 20160279159
    Abstract: The invention relates generally to a pharmacological therapy for a human genetic diseases, specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxyribonucleoside monophosphate, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine monophosphate (dTMP) or deoxycytidine monophosphate (dCMP), or mixtures thereof. This molecular bypass approach is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Application
    Filed: March 28, 2016
    Publication date: September 29, 2016
    Inventors: Michio Hirano, Caterina Garone
  • Patent number: 9255623
    Abstract: An engine with an inclined cylinder, including a horizontally-disposed crankshaft, and two balancer shafts arranged in parallel to the crankshaft. A drive gear for driving the balancer shafts is provided on the crankshaft, and driven gears respectively meshed with the drive gear are provided on the balancer shafts. The two balancer shafts are divided into areas on both sides of a center line of the cylinder and into upper and lower regions relative to an axis of the crankshaft, and axes of the balancer shafts are arranged so as to be placed within a range of a diameter of the drive gear.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: February 9, 2016
    Assignee: KAWASAKI JUKOGYO KABUSHIKI KAISHA
    Inventors: Takahiro Yano, Michio Hirano
  • Patent number: 8899191
    Abstract: A cooling apparatus of an engine includes a cooling fan, a fan housing, and a shroud guiding cooling air from the fan housing to the outer circumferential surface of an engine body portion. Further, a cooling air passage passing throughout in a cylinder head from one side surface of the cylinder head to the other side surface thereof is formed in the cylinder head, and a narrowed or throttle guide portion which guides the cooling air from the interior of the fan housing to an inlet opening of the one side surface of the cooling air passage is formed in the shroud.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: December 2, 2014
    Assignee: Kawasaki Jukogyo Kabushiki Kaisha
    Inventors: Takahiro Yano, Michio Hirano
  • Patent number: 8770157
    Abstract: A cylinder cooling apparatus for an air-cooled engine is equipped with a cooling fan provided on one end section of a crankshaft; a pair of pushrod insertion holes for air intake and exhaust valves formed in a cylinder outer circumferential wall section; a fan shroud for covering the cooling fan and for covering the cylinder outer circumferential wall section in which the pushrod insertion holes are formed; a cutout ventilating section formed in the cylinder outer circumferential wall section between the pair of pushrod insertion holes; and tunnel-shaped ventilating holes formed in the cylinder outer circumferential wall section between the pushrod insertion hole disposed on the side of the cooling fan and a cylinder bore and extending from the cylinder outer circumferential wall section on the side of the cooling fan to the cutout ventilating section.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: July 8, 2014
    Assignee: Kawasaki Jukogyo Kabushiki Kaisha
    Inventors: Takahiro Yano, Michio Hirano
  • Patent number: 8720403
    Abstract: A balancer shaft of an engine includes a pair of journal portions, a first stage balance weight and a second stage balance weight. The first stage balance weight is formed between the journal portions and eccentrically arranged with respect to an axis. The second stage balance weight is formed on a center part of the first stage balance weight in the axial direction and projects outward from the first stage balance weight in a radial direction. The balancer shaft has a recess portion on the opposite side of the eccentricity direction.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: May 13, 2014
    Assignee: Kawasaki Jukogyo Kabushiki Kaisha
    Inventors: Takahiro Yano, Michio Hirano, Shinya Akase
  • Patent number: D709522
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: July 22, 2014
    Assignee: Kawasaki Jukogyo Kabushiki Kaisha
    Inventors: Takahiro Yano, Michio Hirano
  • Patent number: D709523
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: July 22, 2014
    Assignee: Kawasaki Jukogyo Kabushiki Kaisha
    Inventors: Masahiro Nonaka, Michio Hirano, Takao Sasamura, Toru Minami