Abstract: An autofocus device includes a stage, a magnifying optical system, a light source device, an iris which is arranged at a position opposite to a sample of the magnifying optical system and configured to limit a light beam emitted from the light source device, and an AF camera which receives, via the magnifying optical system, a reflected light beam which is reflected from a reflection surface after the light beam reaches a glass member via the iris and the magnifying optical system. The light source device emits the light beam at a non-zero angle relative to the axis of the magnifying optical system. The control unit adjusts the position of the stage so as to match the position of a captured image of a shield with a target position. With such a configuration, it is possible to achieve the autofocus at high speed.

Abstract: It is an object to provide a method for evaluating a medicinal substance targeting a G protein-coupled receptor (GPCR). Specifically, the present invention relates to a method for evaluating the activity of a GPCR comprising a step of bringing a target substance into contact with a cell expressing a GPCR on the cell membrane; and a step of determining the diffusive dynamics of the GPCR on the cell membrane.

Abstract: An autofocus device includes a stage, a magnifying optical system, a light source device, an iris which is arranged at a position opposite to a sample of the magnifying optical system and configured to limit a light beam emitted from the light source device, and an AF camera which receives, via the magnifying optical system, a reflected light beam which is reflected from a reflection surface after the light beam reaches a glass member via the iris and the magnifying optical system. The light source device emits the light beam at a non-zero angle relative to the axis of the magnifying optical system. The control unit adjusts the position of the stage so as to match the position of a captured image of a shield with a target position. With such a configuration, it is possible to achieve the autofocus at high speed.

Abstract: It is an object to provide a method for evaluating a medicinal substance targeting a G protein-coupled receptor (GPCR). Specifically, the present invention relates to a method for evaluating the activity of a GPCR comprising a step of bringing a target substance into contact with a cell expressing a GPCR on the cell membrane; and a step of determining the diffusive dynamics of the GPCR on the cell membrane.