Patents by Inventor Michio Kurosu

Michio Kurosu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12129272
    Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein.
    Type: Grant
    Filed: February 1, 2023
    Date of Patent: October 29, 2024
    Inventors: William M. Clemons, Michio Kurosu
  • Publication number: 20240325341
    Abstract: of treating Gram-negative bacteria that also exhibit resistance to the anti-bacterial compound colistin (MIC?50 mg/mL) except for Burkholderia, Proteus, and Serratia that comprises contacting the bacteria with an aqueous pharmaceutical composition containing a rose bengal (RB) compound of Formula I, below, dissolved or dispersed therein at a concentration of about 0.01 to about 15 mg/mL and irradiating those contacted bacteria with light of the wavelength about 500 nm to about 600 nm for a time period of about 1 to about 10 minutes to provide a light dose of about 16 to about 160 J/cm2, treat and kill the irradiated bacteria wherein X, R1, R2 and M+ are defined within.
    Type: Application
    Filed: March 25, 2024
    Publication date: October 3, 2024
    Applicants: Provectus Pharmatech, Inc., University of Tennessee Research Foundation
    Inventors: Michio KUROSU, Dominic Rodrigues, Edward V. Pershing, Bruce Horowitz, John Lacey, Eric A. Wachter
  • Publication number: 20240199677
    Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein.
    Type: Application
    Filed: February 1, 2023
    Publication date: June 20, 2024
    Inventors: William M. Clemons, Michio Kurosu
  • Publication number: 20230340006
    Abstract: Provided herein are compounds and methods of using these compounds to treat disorders related to DPAGT1 function, including cancer and bacterial infections.
    Type: Application
    Filed: June 30, 2021
    Publication date: October 26, 2023
    Inventors: Michio KUROSU, Katsuhiko MITACHI, William M. Clemons
  • Publication number: 20230270657
    Abstract: The present invention contemplates a topical ophthalmic system for treating a Gram-positive bacterially-infected mammalian eye. The system comprises an ophthalmic composition containing a halogenated fluorescein or a pharmaceutically acceptable salt or ester thereof dissolved or dispersed in an aqueous ophthalmic carrier and present in an anti-bacterial keratitis-treating effective concentration of about 0.2 µg/mL to about 50 µg/mL. The ophthalmic composition has a pH value of about 6.5 to about 7.6, a viscosity of about 10 to about 300 cps and an osmolality of about 270 mOsm/kg to about 340 mOsm/kg. The ophthalmic composition is present in a vessel opaque to actinic light. Also contemplated is a method of treating a mammal having a Gram-positive bacterial infection of an eye by administering the ophthalmic composition to the infected eye and maintaining the treated eye in the substantial absence of actinic light for about 3 hours to about 12 hours.
    Type: Application
    Filed: December 27, 2022
    Publication date: August 31, 2023
    Applicants: Provectus Pharmatech, Inc., University of Tennessee Research Foundation
    Inventors: Michio Kurosu, Dominic Rodrigues, Edward V. Pershing, Bruce Horowitz, John Lacey, III, Eric A. Wachter, Edward P. Gamson
  • Publication number: 20230233515
    Abstract: This invention contemplates combined use of a rose bengal (RB) derivative with irradiation of bacteria with light to treat and kill the irradiated bacteria. In one aspect, Gram-positive bacteria are treated in a method in which the bacteria are contacted with an aqueous pharmaceutical composition containing a rose bengal (RB) compound of Formula I, discussed within, dissolved or dispersed therein at about 0.2 to about 3.1 µg/mL. Those contacted bacteria are contacted with light of the wavelength about 500 nm to about 600 nm for a time period of about 1 to about 10 minutes to provide a light dose of about 0.7 to about 7.2 J/cm2. A similar method is contemplated for treating Gram-negative bacteria that are one or more of Burkholderia, Salmonella, and Proteus using an aqueous pharmaceutical composition containing about 2 to about 15 µM concentration of the RB compound.
    Type: Application
    Filed: December 27, 2022
    Publication date: July 27, 2023
    Applicants: Provectus Pharmatech, Inc., University of Tennessee Research Foundation
    Inventors: Michio KUROSU, Dominic RODRIGUES, Edward V. PERSHING, Bruce HOROWITZ, John LACEY, Eric A. WACHTER
  • Patent number: 11597743
    Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: March 7, 2023
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: William M. Clemons, Michio Kurosu
  • Publication number: 20200361981
    Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein. Also provided are methods of inhibiting dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of any of the compounds or compositions described herein.
    Type: Application
    Filed: January 11, 2019
    Publication date: November 19, 2020
    Inventors: William M. Clemons, Michio Kurosu
  • Patent number: 8884061
    Abstract: The invention provides compounds of the formula: or a pharmaceutically acceptable salt thereof, where m, n, R1, R2, R3 R4, R5, R6, R7 are those defined herein. The invention also provides pharmaceutical compositions comprising a compound of the invention, methods for using compounds and/or pharmaceutical compositions of the invention, and methods for synthesizing compounds of the invention.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: November 11, 2014
    Assignee: Colorado State University Research Foundation
    Inventors: Michio Kurosu, Dean Calvin Crick
  • Patent number: 7858825
    Abstract: The invention provides compounds that are useful as linkers for solid phase synthesis and as protecting groups, and methods for producing and using the same.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: December 28, 2010
    Assignee: Colorado State University Research Foundation
    Inventors: Michio Kurosu, Dean Crick
  • Publication number: 20090030084
    Abstract: The invention provides compounds of the formula: or a pharmaceutically acceptable salt thereof, where m, n, R1, R2, R3 R4, R5, R6, R7 are those defined herein. The invention also provides pharmaceutical compositions comprising a compound of the invention, methods for using compounds and/or pharmaceutical compositions of the invention, and methods for synthesizing compounds of the invention.
    Type: Application
    Filed: March 2, 2007
    Publication date: January 29, 2009
    Inventors: Michio Kurosu, Dean Calvin Crick
  • Publication number: 20080200719
    Abstract: The invention provides compounds that are useful as linkers for solid phase synthesis and as protecting groups, and methods for producing and using the same.
    Type: Application
    Filed: February 15, 2008
    Publication date: August 21, 2008
    Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Michio Kurosu, Dean Crick