Patents by Inventor Michio Terasawa
Michio Terasawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5686479Abstract: An immunosuppressive drug, an autoimmune disease treating drug, an immunosuppression enhancing drug and a cell adhesion inhibitor, each containing a thienotriazolodiazepine compound wherein the 2-position of its diazepine ring is alkylated as an active ingredient, an immunosuppression method, an autoimmune disease treating method, an immunosuppression enhancing method and a cell adhesion inhibiting method, each of which comprising administering the compound, and uses of the compound for the production of an immunosuppressive drug, an autoimmune disease treating drug, an immunosuppression enhancing drug and a cell adhesion inhibitor.Type: GrantFiled: June 10, 1994Date of Patent: November 11, 1997Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Takeki Okumoto, Kenji Chiba, Yukio Hoshino, Hirotsugu Komatsu, Mariko Nagasawa, Hidekazu Aratani, Michio Terasawa, Minoru Moriwaki
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Patent number: 5286858Abstract: Stable crystals of an acid addition salt of an optically active thienotriazolodiazepine compound or its hydrate of the formula ##STR1## wherein R.sup.1 is hydrogen, R.sup.2 is 2-phenylethyl substituted by alkyl having 1 to 5 carbon atoms, 2-morpholinocarbonylethyl or alkyl having 6 to 12 carbon atoms, or R.sup.1 and R.sup.2 may combinedly form a saturated 5-membered ring having one substituent selected from the group consisting of morpholinomethyl, morpholinocarbonyl and N,N-dipropylcarbamoyl, R.sup.3 is halogen, alkyl having 1 to 5 carbon atoms or alkoxy having 1 to 5 carbon atoms, R.sup.4 is trifluoromethyl or alkyl having 1 to 5 carbon atoms, R.sup.5 is hydrogen or methyl, m is 1-2, and n is 0-2.Type: GrantFiled: October 11, 1991Date of Patent: February 15, 1994Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Minoru Moriwaki, Syuji Yuasa, Hiroyuki Kitani, Michio Terasawa
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Patent number: 5278156Abstract: 11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof.11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.Type: GrantFiled: March 24, 1992Date of Patent: January 11, 1994Assignees: Kuraray Co., Ltd., Taiho Pharmaceutical Co., Ltd.Inventors: Yutaka Mizushima, Keiko Hoshi, Rie Igarashi, Hirofusa Ajioka, Noriyuki Yamamoto, Masahito Komuro, Koichi Kanehira, Masayuki Inoue, Takashi Nishida, Michio Terasawa, Kenzo Arizono
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Patent number: 5198452Abstract: A styryl compound of the formula(I): ##STR1## wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt or an ester thereof is disclosed.Since the compounds of the present invention possess potent and long-lasting leukotriene-antagonistic actions and inhibitory actions against leukotriene, and exhibit better absorption by the oral administration.Further, the compounds of the present invention possess 5-lipoxygenase-inhibitory actions and/or cyclooxygenase-inhibitory actions, inhibitory actions to biosynthesis of LTB4, chemotactic actions against human leucoccyte, chymase-inhibitory actions, inhibitory actions to release of histamine or antihistamine actions.Type: GrantFiled: July 10, 1991Date of Patent: March 30, 1993Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Mitsuhiro Konishi, Minoru Kawakami, Michio Terasawa, Toshio Hamasaki
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Patent number: 5028603Abstract: There are provided novel ester-substituted thienotriazolodiazepines useful for the treatment of various PAF-induced diseases.Type: GrantFiled: February 3, 1989Date of Patent: July 2, 1991Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Tetsuya Tahara, Minoru Moriwaki, Masao Abe, Michio Terasawa
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Patent number: 5015746Abstract: 11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof.11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.Type: GrantFiled: January 23, 1989Date of Patent: May 14, 1991Assignee: Kuraray Co., Ltd.Inventors: Yutaka Mizushima, Keiko Hoshi, Rie Igarashi, Hirofusa Ajioka, Noriyuki Yamamoto, Masahito Komuro, Koichi Kanehira, Masayuki Inoue, Takashi Nishida, Manzo Shiono, Michio Terasawa, Kenzo Arizono
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Patent number: 4937240Abstract: A thienotriazolodiazepine compound of the formula: ##STR1## wherein each symbol is as defined in the specification or a pharmaceutically acceptable salt thereof, and pharmaceutical uses thereof.Said compounds exhibit PAF-antagonistic activity and are useful for the prevention or treatment of various PAF-induced diseases.Type: GrantFiled: January 30, 1989Date of Patent: June 26, 1990Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Minoru Moriwaki, Hiroshi Tanaka, Michio Terasawa, Tetsuya Tahara
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Patent number: 4808593Abstract: Benzopyranopyridineacetic acid ester compounds of the formula: ##STR1## wherein R.sup.1, and R.sup.2 and R.sup.3 independently represent hydrogen or C.sub.1-4 alkyl; and n is 1 or 2, and their pharmaceutical use are disclosed.These compounds possess antiinflammatory, analgesic and antipyretic activities with less adverse action on the gastrointestinal tract.Type: GrantFiled: March 28, 1988Date of Patent: February 28, 1989Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Takanori Oe, Kazuyuki Kawasaki, Michio Terasawa, Tomonori Imayoshi
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Patent number: 4808620Abstract: A pyrazolopyridine compound of the formula: ##STR1## or a salt thereof, wherein each symbol is as defined in the specification. Said compounds exhibit antiinflammatory, analgesic, antipyretic, antiallergic, antiarthritic, antirheumatic activities or inhibitory activities on platelet aggregation.Type: GrantFiled: July 22, 1987Date of Patent: February 28, 1989Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Takanori Oe, Kazuyuji Kawasaki, Michio Terasawa, Tomonori Imayoshi, Yukihiro Yasunaga
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Patent number: 4728644Abstract: Purine derivatives of the formula: ##STR1## wherein R is hydrogen, alkyl or phenyl which may be substituted by at least one halogen, lower alkyl or lower alkoxy; each of R.sup.1 and R.sup.2 is hydrogen, alkyl, cycloalkyl, hydroxyalkyl, dialkylaminoalkyl, cyclic aminoalkyl, alkenyl or aralkyl, or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form a heterocycle; and each of R.sup.3 and R.sup.4 is hydrogen or lower alkyl, and pharmaceutically acceptable acid addition salts thereof and/or hydrates, methods of preparing said compounds and pharmaceutical compositions containing said compounds. The purine compounds exhibit antiinflammatory, analgesic, antipyretic and antiallergic activity, and inhibitory activity on platelet aggregation, and are useful as drugs.Type: GrantFiled: July 22, 1985Date of Patent: March 1, 1988Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Hiroshi Yuki, Hiroyuki Sueoka, Mitsuyoshi Yasumoto, Michio Terasawa, Tomonori Imayoshi
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Patent number: 4576940Abstract: 3-Indolecarboxamide compounds of the formula: ##STR1## inclusive of pharmaceutically acceptable acid addition salt and/or hydrate forms thereof, wherein R.sup.1 is C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl-C.sub.1-8 alkyl, allyl, propargyl, or phenyl or phenyl-C.sub.1-4 alkyl which may be optionally substituted, on the benzene ring, by at least one substituent selected from the group consisting of halogen, trifluoromethyl, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; R.sup.2 is H or C.sub.1-6 alkyl; R.sup.3 is H, halogen, C.sub.2-6 alkanoyloxy, benzoyloxy, C.sub.1-4 alkoxy, benzyloxy, hydroxy or C.sub.1-4 alkyl; R.sup.4 is H, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or hydroxy; R.sup.5 is H or C.sub.1-4 alkoxy; A is ethylene or trimethylene, which may be optionally substituted by C.sub.1-4 alkyl; n is zero, 1 or 2; and m is zero or 1, are useful as drugs for the prevention and treatment of various allergic diseases.Type: GrantFiled: August 10, 1984Date of Patent: March 18, 1986Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Tetsuya Tahara, Tsuguo Ikebe, Michio Terasawa, Tomonori Imayoshi
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Patent number: 4525348Abstract: An antiinflammatory and analgesic gelled ointment contains pranoprofen, at least one member selected from the group consisting of lower aliphatic alcohol, polyethylene glycol, methyl ethyl ketone and acetone, a gelling agent selected from the group consisting of carboxyvinyl polymer, hydroxyethyl cellulose, alginic acid and carboxymethyl cellulose, a water-soluble basic substance selected from the group consisting of ammonia, sodium hydroxide, potassium hydroxide, triethanolamine, diethanolamine, diisopropanolamine, triisopropanolamine and triethylamine, and water.Type: GrantFiled: December 19, 1983Date of Patent: June 25, 1985Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Kenzo Arizono, Michio Terasawa, Michiharu Nobutoki