Patents by Inventor Michiyo Okui

Michiyo Okui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Artificial antibody library with super-repertory
    Patent number: 8178320
    Abstract: An artificial antibody library with a super-repertory (1011 or more) is constructed by: using a cDNA library as a template, amplifying a fragment containing the CDR1 and CDR2s regions of the VH or VL region of immunoglobulin gene and a fragment containing the CDR3 region each by the PCR method; integrating the VH library and the VL library, which are little contaminated with unexpressionable repertory and have high safety, into an non-expression vector; transferring it into a host; and then shuffling the VH region in the VH library with the VL region in the VL library.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: May 15, 2012
    Assignee: Keio University
    Inventors: Nobuyoshi Shimizu, Atsushi Takayanagi, Michiyo Okui
  • Artificial antibody library with super-repertory
    Publication number: 20060057632
    Abstract: An artificial antibody library with a super-repertory (1011 or more) is constructed by: using a cDNA library as a template, amplifying a fragment containing the CDR1 and CDR2s regions of the VH or VL region of immunoglobulin gene and a fragment containing the CDR3 region each by the PCR method; integrating the VH library and the VL library, which are little contaiminated with unexpressionable repertory and have high safety, into an nono-expression vector; transferring it into a host; and then shuffling the VH region in the VH library with the VL region in the VL library.
    Type: Application
    Filed: November 22, 2002
    Publication date: March 16, 2006
    Applicant: Keio University
    Inventors: Nobuyoshi Shimizu, Atsushi Takayanagi, Michiyo Okui