Patents by Inventor MICKAËL GUEDJ

MICKAËL GUEDJ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR ADAPTING DOSES OF COMBINATION THERAPIES
    Publication number: 20200306211
    Abstract: The present invention relates to methods for improving dose finding process for combinations of several drugs and/or adapting the dosage of combinatorial treatment. More particularly the invention relates to methods for identifying more efficient dose of active pharmaceutical ingredients (APIs) within combination therapies. This invention also relates to methods for optimizing a therapeutic efficiency of combined therapies.
    Type: Application
    Filed: November 30, 2015
    Publication date: October 1, 2020
    Inventors: Daniel Cohen, Ilya Chumakov, Mickael Guedj, Rodolphe Hajj
  • BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS
    Publication number: 20200085790
    Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.
    Type: Application
    Filed: November 25, 2019
    Publication date: March 19, 2020
    Inventors: DANIEL COHEN, ILYA CHUMAKOV, SERGUEI NABIROCHKIN, EMMANUEL VIAL, MICKAEL GUEDJ
  • Compositions for treating neurological disorders
    Patent number: 10434109
    Abstract: The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: October 8, 2019
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Emmanuel Vial, Mickael Guedj
  • COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS
    Publication number: 20180338988
    Abstract: The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.
    Type: Application
    Filed: July 2, 2018
    Publication date: November 29, 2018
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Emmanuel Vial, Mickael Guedj
  • DIAGNOSTIC TOOLS FOR ALZHEIMER'S DISEASE
    Publication number: 20180275144
    Abstract: The present invention relates to methods of detecting Alzheimer's disease using novel biomarkers or sets thereof. The novel biomarkers can be measured in biological body fluids or easily available extracts of biopsies.
    Type: Application
    Filed: February 2, 2016
    Publication date: September 27, 2018
    Inventors: DANIEL COHEN, ILYA CHUMAKOV, SERGUEI NABIROCHKIN, MICKAEL GUEDJ, RODOLPHE HAJJ
  • COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS
    Publication number: 20180125867
    Abstract: The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 10, 2018
    Inventors: DANIEL COHEN, ILYA CHUMAKOV, SERGUEI NABIROCHKIN, EMMANUEL VIAL, MICKAEL GUEDJ
  • Composition comprising torasemide and baclofen for treating neurological disorders
    Patent number: 9931326
    Abstract: The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of multiple sclerosis, Alzheimer's disease, Alzheimer's disease-related disorders, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.
    Type: Grant
    Filed: September 1, 2014
    Date of Patent: April 3, 2018
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Mickael Guedj, Emmanuel Vial
  • Compositions for treating neurological disorders
    Patent number: 9867837
    Abstract: The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: January 16, 2018
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Emmanuel Vial, Mickaël Guedj
  • Treatment of cerebral ischemia
    Patent number: 9820978
    Abstract: The present invention relates to new compositions and methods for protecting neuronal cells from ischemic or hypoxic events. More precisely, this invention provides new combinatorial therapies that efficiently protect neuronal cells from ischemia or hypoxia.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: November 21, 2017
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Emmanuel Vial, Mickaël Guedj
  • BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS
    Publication number: 20170231958
    Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.
    Type: Application
    Filed: April 24, 2017
    Publication date: August 17, 2017
    Inventors: DANIEL COHEN, ILYA CHUMAKOV, SERGUEI NABIROCHKIN, EMMANUEL VIAL, MICKAEL GUEDJ
  • Baclofen and acamprosate based therapy of neurological disorders
    Patent number: 9636316
    Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: May 2, 2017
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Emmanuel Vial, Mickael Guedj
  • COMPOSITION COMPRISING TORASEMIDE AND BACLOFEN FOR TREATING NEUROLOGICAL DISORDERS
    Publication number: 20160206603
    Abstract: The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.
    Type: Application
    Filed: September 1, 2014
    Publication date: July 21, 2016
    Inventors: DANIEL COHEN, ILYA CHUMAKOV, SERGUEI NABIROCHKIN, MICKAEL GUEDJ, EMMANUEL VIAL
  • DIAGNOSTIC TOOLS FOR ALZHEIMER'S DISEASE
    Publication number: 20160195547
    Abstract: The present invention relates to methods of detecting Alzheimer's disease using novel biomarkers. The novel biomarkers can be measured in biological body fluids or easily available extracts of biopsies. The present invention also relates to methods for identification of the stage of the disease, assessing the responsiveness to the treatment and the efficacy of treatment in subjects having Alzheimer's disease.
    Type: Application
    Filed: July 30, 2014
    Publication date: July 7, 2016
    Inventors: DANIEL COHEN, ILYA CHUMAKOV, SERGUEI NABIROCHKIN, MICKAEL GUEDJ, RODOLPHE HAJJ
  • BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS
    Publication number: 20160000736
    Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.
    Type: Application
    Filed: September 22, 2015
    Publication date: January 7, 2016
    Inventors: DANIEL COHEN, ILYA CHUMAKOV, SERGUEI NABIROCHKIN, EMMANUEL VIAL, MICKAEL GUEDJ
  • Baclofen and acamprosate based therapy of neurological disorders
    Patent number: 9144558
    Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: September 29, 2015
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Emmanuel Vial, Mickael Guedj
  • BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS
    Publication number: 20140378440
    Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.
    Type: Application
    Filed: September 8, 2014
    Publication date: December 25, 2014
    Inventors: DANIEL COHEN, ILYA CHUMAKOV, SERGUEI NABIROCHKIN, EMMANUEL VIAL, MICKAEL GUEDJ
  • Baclofen and acamprosate based therapy of neurological disorders
    Patent number: 8865769
    Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: October 21, 2014
    Assignee: Pharnext
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Emmanuel Vial, Mickael Guedj
  • Baclofen and acamprosate based therapy of neurological disorders
    Patent number: 8741886
    Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: June 3, 2014
    Assignee: Pharnext
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Emmanuel Vial, Mickael Guedj
  • TREATMENT OF CEREBRAL ISCHEMIA
    Publication number: 20140080873
    Abstract: The present invention relates to new compositions and methods for protecting neuronal cells from ischemic or hypoxic events. More precisely, this invention provides new combinatorial therapies that efficiently protect neuronal cells from ischemia or hypoxia.
    Type: Application
    Filed: March 1, 2012
    Publication date: March 20, 2014
    Applicant: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Emmanuel Vial, Mickaël Guedj
  • COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS
    Publication number: 20140038927
    Abstract: The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.
    Type: Application
    Filed: August 30, 2013
    Publication date: February 6, 2014
    Applicant: PHARNEXT
    Inventors: DANIEL COHEN, ILYA CHUMAKOV, SERGUEI NABIROCHKIN, EMMANUEL VIAL, MICKAËL GUEDJ