Abstract: Organ transplantation remains the only definitive therapeutic solution for many pathologies, but the number of currently available grafts is largely insufficient. A new approach is proposed to quantitatively evaluate isolated organs by ultrasound, which enables to safely admit more isolated organs as grafts available for transplantation. The isolated organ (2) is received in an organ preservation container (3) made of ultrasound transparent material, and the isolated organ is imaged by an ultrasound imaging probe (6) through the container (3). The ultrasound image of the isolated organ is used to determine a quantitative index representing viability of the isolated organ.

Abstract: Methods and systems are provided for decoding movement intentions using functional ultrasound (fUS) imaging of the brain. In one example, decoding movement intentions include determining a memory phase of a cognitive state of the brain, the memory phase between a gaze fixation phase and movement execution phase, and determining one or more movement intentions including one or more of intended effector (e.g., hand, eye) and intended direction (e.g., right, left) according to a machine learning algorithm trained to classify one or more movement intentions simultaneously.

Abstract: Nowadays, the interest to use ultrasound waves in medical field is well established. Such ultrasound waves may be focused for treating a zone in an organ such as the brain for instance. The focus allows to treat only the zone relative to the disease and avoid treating a healthy zone. Therefore, it is mandatory to use an image guidance system to monitor in real time where the ultrasound waves are focused. The guidance can be performed by Magnetic Resonance Imaging (MRI), Ultrasound Imaging (echography), or Optical Imaging (neuronavigation). However, such systems increase the cost and the complexity of the whole process. The present disclosure overcomes the above drawbacks by proposing a self-positioning acoustic lens allowing to ensure good ultrasound waves transmission in the zone to treat without requiring to the use of a navigation system.

Abstract: A method for measuring a mean visco-elasticity value for a soft material using a single probe carrying at least one transducer includes inducing, in a constraint zone, at least one burst of mechanical vibrations in order to generate internal shear waves in the tissue propagating from the constraint zone into the tissue, measuring, with the transducer, transient tissue displacements in at least one first measurement zone in the tissue, the first measurement zone being located away from the constraint zone, and estimating a mean visco-elasticity of the region of the tissue situated between the constraint zone and the first measurement zone from the measured transient tissue displacements of the tissue in the first measurement zone.

Abstract: A cardiac device comprises a transmitter (10) arranged to transmit at least one wave, a probe (12) arranged to measure a shear wave caused by a wave coming from the transmitter (10), a detector (14) arranged to detect a systole phase in an electrocardiographic signal, and an estimator (16) arranged to determine, during at least one cardiac cycle, the propagation speed of a plurality of shear waves caused by the transmission of waves in several directions towards the heart of a patient, to determine using the detector (14) that which has a maximum propagation speed during the systole phase, and to derive an active cardiac stress response therefrom (160).

Abstract: The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a ?-ray, and c) determining the at least one property of the object based on the first data and the second data.

Abstract: Functional imaging, in particular functional ultrasound imaging, is becoming a powerful tool for early detection of disorders such as neurodegenerative diseases. The present disclosure proposes a reliable method for such early detection, by delivering a stimulus to the nervous system, performing a functional imaging of an area of interest of the nervous system activated by the stimulus to obtain a series of hemodynamic Doppler images of the vascular network in the area of interest, and computing, from the series of hemodynamic Doppler images, a hemodynamic response (22) to the stimulus. The shape of hemodynamic response may be used to detect health disorders.

Abstract: The invention concerns a multi-sensor brain detecting apparatus, the detecting apparatus being adapted to obtain two different physical values of a brain of a subject, the detecting apparatus comprising: a set of sensors comprising an ultrasound transducer adapted to produce ultrasound waves, a frame with a position with relation to the brain known with a stereotaxic precision, the frame being adapted to hold a sensor that can be positioned at a specific location by a user of the detecting apparatus without using a tool.

Abstract: Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method, which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.

Abstract: Method for imaging vascular activity at a microscopic scale in at least one area of a vascular network of an organ, of a human or animal, the method including: (a) transmitting a series of successive incident ultrasonic waves in the at least one area by an array of ultrasonic transducers, the array of ultrasonic transducers extending along at least one direction and the incident ultrasonic waves being propagated in a direction perpendicular to the array of transducers; (b) acquiring a set of raw data from backscattered ultrasonic waves by said array of transducers; (c) generating a series of successive ultrasound images from said raw data; (d) detecting at least one isolated ultrasound contrast agent in the ultrasound images; (e) localizing the position of said at least one isolated ultrasound contrast agent with a precision inferior to the wavelength of the waves; (f) generating an at least 2D backscattering amplitude image by attributing for each pixel a value representative of the measured backscatterin

Abstract: While 3D ultrasound imaging is becoming a powerful tool in medical field. the main drawback is the difficulty to image large 3D volume. mainly related to the dimensions of the 2D array of transducers. In order to not lose in spatial resolution, it is necessary to use an array of transducers. wherein the size of the transducers does not exceed the wavelength of the ultrasound wave. Such requirement leads to dimensions of array for imaging large 3D volume which are not reachable or at too high cost with the current technology. The present disclosure overcomes the above technology limitation by using greater transducers, and where each transducer has a reception surface with a curved shape or is fitted with an acoustic lens. Such configuration of transducers leads to 2D array of transducers suitable for imaging large 3D volume, as a brain or a heart. with high resolution and high sensitivity.

Abstract: An imaging method including: a) acquiring N successive positron emission tomography (PET) low resolution images ?i and simultaneously, N successive Ultrafast Ultrasound Imaging (UUI) images Ui of a moving object; b) determining from each UUI image Ui, the motion vector fields Mi that corresponds to the spatio-temporal geometrical transformation of the motion of the object; c) obtaining a final estimated high resolution image H of the object by iterative determination of a high resolution image Hn+1 obtained by applying several correction iterations to a current estimated high resolution image Hn, n being the number of iterations, starting from an initial estimated high resolution image H1 of the object, each correction iteration including at least: i) warping the estimated high resolution image Hn using the motion vector fields Mi to determine a set of low resolution reference images Lni; ii) determining a differential image Di by difference between each PET image ?i and the corresponding low resolution re

Abstract: An ultrasound probe holding device configured to attach to the head of an infant for transfontanellar imaging is disclosed, including a head pad configured to be in contact with the head of the infant and including a central opening, wherein the head pad is configured to receive an ultrasound probe; a pad squeezer, including a central opening and configured to cooperate with the head pad to allow an axial guidance of the head pad along a guidance axis substantially perpendicular to a surface tangent to the head of the infant; a device holder configured to be attached to the head of the infant and exert a downward force on the pad squeezer, along said guidance axis; and a repellent configured to exert a repellent force between the pad squeezer and the head pad when the device holder exerts the downward force on the pad squeezer.

Abstract: Devices and methods for reversibly stimulating neuronal cells in a subject. The devices include a module for generating ultrasounds at 4 MHz or more to stimulate neuronal cells expressing mechanosensitive channels with the ultrasounds. The methods include expressing mechanosensitive channels into neuronal cells and exposing the cells to ultrasounds at 4 MHz or more. Also, the use of the methods or devices for visual restoration in a subject.

Abstract: The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a ?-ray, and c) determining the at least one property of the object based on the first data and the second data.

Abstract: A method for mapping fibrous media by propagation of ultrasound from a set transducers, wherein: a number of unfocused incident ultrasonic waves having different wavefronts are emitted; the signals reverberated by the medium toward each transducer are captured; coherent signals respectively corresponding, for each transducer, to contributions coming from different fictitious focal points in the medium are determined; and then the orientation of the fibers is determined by comparing a spatial coherence between said coherent signals, in a plurality of directions.

Abstract: The present invention relates to the field of ultrasounds and imagining of the coronary blood flow of the heart. Patients with coronary microvascular dysfunction (CMD) have poor prognostic with significantly higher rates of cardiovascular events, including hospitalization for heart failure, sudden cardiac death, and myocardial infarction (MI). Despite the urgent clinical need, there are no non-ionizing and non-invasive techniques available in clinic to directly visualize the coronary microvasculature and assess the local coronary microvascular system. Flow imaging remains a difficult task to perform in the heart because of the fast movements of this organ. In order to overcome the limitations of actual imaging methods for the coronary blood flow, the inventors proposed an ultrasound ultrafast imaging method that automatically detect the time periods in which the myocardium velocity is low and estimate the coronary flow velocity and the tissue velocity from the same data acquisition.

Abstract: An apparatus for treating vascular thrombosis with ultrasound, includes a therapeutic ultrasonic transducer, suitable for generating focused ultrasonic waves that propagate along an emission axis; an imaging ultrasonic transducer associated with the therapeutic transducer; a means for moving the focal spot of the therapeutic ultrasonic transducer along the emission axis with respect to the imaging transducer; a motorized mechanical system for translating the transducers along at least a first axis parallel to the emission axis and a second axis perpendicular to the first; and an electronic control system for driving the motorized mechanical system and the means for moving the focal spot of the therapeutic transducer.

Abstract: The present invention aims at improving the Doppler imaging of a biological sample comprising blood. For this, it is proposed a method for imaging a biological sample (10), the sample (10) comprising blood (14) comprising diffusors and solid tissue (16), the method comprising obtaining observation, each observation being characterized by a different point spread function associating a signal to each location of the region of interest, the signal comprising a first contribution representative of the diffusors of blood vessels within the location, a second contribution representative of the tissue diffusors and a third contribution representative of blood signal associated to blood diffusors outside of the location, and estimating, for each location, the blood flow by using a statistical analysis.

Abstract: An ultrasound imaging and therapy device includes an array of concentric annular ultrasound transducers, and an ultrasound imaging device situated inside an innermost transducer of the plurality of concentric annular ultrasound transducers, wherein it further comprises a mechanical linkage allowing a tilting movement of the array of concentric annular ultrasound transducers with respect to the ultrasound imaging device and in that the ultrasound imaging device protrudes in an axial direction from the array of concentric annular ultrasound transducers; whereby the ultrasound imaging device can be kept stationary and in direct or indirect contact with a patient's skin while the array of concentric annular ultrasound transducers is tilted so as to move a focal point of ultrasound waves generated by the concentric annular ultrasound transducers within an imaging region of the ultrasound imaging device.