Patents by Inventor Mickey Urdea
Mickey Urdea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8021839Abstract: Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid analogs and that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/polynucleotide hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/polynucleotide hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.Type: GrantFiled: February 23, 2007Date of Patent: September 20, 2011Assignee: Investigen, Inc.Inventors: Charles Robert Bupp, II, K. Yeon Choi, Rachel Anne Holmes-Davis, Alexander Izmailov, Heather Koshinsky, Christopher Jon Nulf, Mickey Urdea, Miaomiao Wang, Brian David Warner, Michael Zwick
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Publication number: 20090263400Abstract: Disclosed are methods of identifying subjects with osteoporosis or osteopenia, subjects at risk for developing osteoporosis, osteopenia, and bone fractures, methods of evaluating the effectiveness of osteoporosis treatments in subjects with osteoporosis or osteopenia, and methods of selecting therapies for treating osteoporosis or osteopenia, using biomarkers.Type: ApplicationFiled: March 20, 2009Publication date: October 22, 2009Applicant: TETHYS BIOSCIENCE, INC.Inventors: Mickey Urdea, Michael McKenna, Patrick Arensdorf
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Publication number: 20090171590Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.Type: ApplicationFiled: November 21, 2008Publication date: July 2, 2009Inventors: Robert PUSKAS, Richard A. Livingston, Douglas D. Held, Barbara Klein, Neolle Fukushima, Robert Freese, Philippe J. Goix, Peter R. David, Mickey Urdea
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Publication number: 20080171319Abstract: Disclosed are methods of identifying subjects with osteoporosis or osteopenia, subjects at risk for developing osteoporosis, osteopenia, and bone fractures, methods of evaluating the effectiveness of osteoporosis treatments in subjects with osteoporosis or osteopenia, and methods of selecting therapies for treating osteoporosis or osteopenia, using biomarkers.Type: ApplicationFiled: February 6, 2007Publication date: July 17, 2008Inventors: Mickey Urdea, Michael McKenna, Patrick Arensdorf
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Publication number: 20080158543Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.Type: ApplicationFiled: August 13, 2007Publication date: July 3, 2008Inventors: Robert Puskas, Richard A. Livingston, Douglas D. Held, Barbara Klein, Noelle Fukushima, Robert Freese, Philippe J. Goix, Peter R. David, Mickey Urdea
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Publication number: 20080096193Abstract: Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a nucleic acid analog that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/nucleic acid analog hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/nucleic acid analog hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.Type: ApplicationFiled: October 24, 2006Publication date: April 24, 2008Inventors: Charles Robert Bupp, K. Yeon Choi, Heather Koshinsky, Christopher Nulf, Mickey Urdea, Miaomiao Wang, Michael Zwick
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Publication number: 20080057590Abstract: Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with arteriovascular disease from other diseases or within sub-classifications of arteriovascular disease, methods of evaluating the risk of arteriovascular events in patients with arteriovascular disease, methods of evaluating the effectiveness of treatments in subjects with arteriovascular disease, and methods of selecting therapies for treating arteriovascular disease.Type: ApplicationFiled: June 7, 2007Publication date: March 6, 2008Inventors: Mickey Urdea, Michael McKenna, Patrick Arensdorf
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Publication number: 20070259377Abstract: Disclosed are methods of identifying subjects with Diabetes, pre-Diabetes, or a pre-diabetic condition, methods of identifying subjects at risk for developing Diabetes, pre-Diabetes, or a pre-diabetic condition, methods of differentially diagnosing diseases associated with Diabetes, pre-Diabetes, or a pre-diabetic condition from other diseases or within sub-classifications of Diabetes, methods of evaluating the risk of progression to Diabetes, pre-Diabetes, or a pre-diabetic condition in patients, methods of evaluating the effectiveness of treatments in subjects with Diabetes, pre-Diabetes, or a pre-diabetic condition, and methods of selecting therapies for treating Diabetes, pre-Diabetes or a pre-diabetic condition, using biomarkers.Type: ApplicationFiled: April 18, 2007Publication date: November 8, 2007Inventors: Mickey Urdea, Michael McKenna, Patrick Arensdorf
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Publication number: 20070231821Abstract: Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid analogs and that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/polynucleotide hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/polynucleotide hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.Type: ApplicationFiled: February 23, 2007Publication date: October 4, 2007Inventors: Charles Bupp, K. Choi, Rachel Holmes-Davis, Alexander Izmailov, Heather Koshinsky, Christopher Nulf, Mickey Urdea, Miaomiao Wang, Brian Warner, Michael Zwick
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Publication number: 20070218519Abstract: Disclosed are methods of identifying subjects with Diabetes or a pre-diabetic condition, methods of identifying subjects at risk for developing Diabetes or a pre-diabetic condition, methods of differentially diagnosing diseases associated with Diabetes or a pre-diabetic condition from other diseases or within sub-classifications of Diabetes, methods of evaluating the risk of progression to Diabetes or a pre-diabetic condition in patients, methods of evaluating the effectiveness of treatments in subjects with Diabetes or a pre-diabetic condition, and methods of selecting therapies for treating Diabetes or a pre-diabetic condition, using biomarkers.Type: ApplicationFiled: October 11, 2006Publication date: September 20, 2007Applicant: Tethys Bioscience, Inc.Inventors: Mickey Urdea, Michael McKenna, Patrick Arensdorf
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Publication number: 20060078998Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.Type: ApplicationFiled: January 28, 2005Publication date: April 13, 2006Inventors: Robert Puskas, Richard Livingston, Douglas Held, Barbara Klein, Noelle Fukushima, Robert Freese, Philippe Goix, Peter David, Mickey Urdea
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Patent number: 4868105Abstract: Methods and compositions are provided for rapid detection of nucleic acid sequences. The method employs two reagent sets. The first set is a labelling set comprising: (1) a first nucleic acid sequence probe having an analyte complementary region and a first recognition sequence region and (2) a labelled sequence complementary to the first recognition sequence region. The second set is a capturing set comprising: (1) a second nucleic acid sequence probe having an analyte complementary region and a second recognition sequence region, (2) a specific binding pair member conjugated to a sequence complementary to the second recognition sequence, and (3) a separating means to which is bound a complementary specific binding pair member. The sample and probes are combined under annealing conditions, followed by addition of the other reagents, separation of the bound label from the supernatant and detection of the label in either phase.Type: GrantFiled: December 11, 1985Date of Patent: September 19, 1989Assignee: Chiron CorporationInventors: Mickey Urdea, Brian Warner