Patents by Inventor Midori Hirai
Midori Hirai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230050758Abstract: A method for purifying a polyethylene glycol compound represented by formula [1], including a Step (A) of dissolving the compound represented by formula [1] in an organic solvent having a Hildebrand solubility parameter of 8 to 10 (cal/cm3)1/2 to obtain a solution, and a Step (B) of mixing the solution with 0.1 to 1 part by mass of an adsorbent made from a hydrotalcite having a specific surface area of 50 to 200 m2/g with respect to 1 part by mass of the compound of the formula [1] to prepare a slurry, where Z, Y1, Y2, A, Polymer, X, a, b, l and m are as defined herein.Type: ApplicationFiled: December 21, 2020Publication date: February 16, 2023Applicant: NOF CORPORATIONInventors: Ryo KAWAHARA, Atsushi SATO, Midori HIRAI, Kyu TAKEUCHI
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Publication number: 20220363824Abstract: A method for purifying a branched polyethylene glycol, which includes adding, to a branched polyethylene glycol compound represented by the following formula [1] and having a weight average molecular weight of 40000 or more: where Z, Y1, Y2, A, Polymer, l, m and b are as defined herein, at least one solid acid selected from magnesium silicate, aluminum silicate, and aluminum magnesium silicate and having a specific surface area of 50 to 250 m2/g in the presence of an aprotic organic solvent to obtain a mixture; stirring the mixture; and subsequently separating the solid acid.Type: ApplicationFiled: December 21, 2020Publication date: November 17, 2022Applicant: NOF CORPORATIONInventors: Midori HIRAI, Kyu TAKEUCHI
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Publication number: 20220185969Abstract: The invention provides a modified bio-related substance that shows further prolonged half-life in blood and further improved stability in the blood of living organisms. In particular, the invention provides a conjugate of a block polymer and a bio-related substance, which conjugate is represented by the following formula (I), wherein each symbol is as described herein.Type: ApplicationFiled: April 15, 2019Publication date: June 16, 2022Applicants: NOF CORPORATION, UNIVERSITA' DEGLI STUDI DI PADOVAInventors: Hiroki YOSHIOKA, Midori HIRAI, Masaki KAMIYA, Gianfranco PASUT
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Publication number: 20210147624Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.Type: ApplicationFiled: March 29, 2019Publication date: May 20, 2021Applicants: NOF Corporation, Tokyo Institute of TechnologyInventors: Hiroki YOSHIOKA, Masaki KAMIYA, Yuji YAMAMOTO, Midori HIRAI, Akiko SASAKI, Nobuhiro NISHIYAMA, Makoto MATSUI, Hiroyasu TAKEMOTO, Kazuki MIYAUCHI, Takahiro NOMOTO, Keishiro TOMODA
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Publication number: 20210023231Abstract: The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.Type: ApplicationFiled: March 29, 2019Publication date: January 28, 2021Applicants: NOF CORPORATION, TOKYO INSTITUTE OF TECHNOLOGYInventors: Hiroki YOSHIOKA, Masaki KAMIYA, Yuji YAMAMOTO, Midori HIRAI, Akiko SASAKI, Nobuhiro NISHIYAMA, Makoto MATSUI, Hiroyasu TAKEMOTO, Kazuki MIYAUCHI, Takahiro NOMOTO, Keishiro TOMODA
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Patent number: 10752732Abstract: A purification method of a polyethylene glycol compound having one carboxyl group. In the method, an aqueous solution of the compound having a pH of 8 to 11 is prepared, the aqueous solution and a mixed organic solvent are mixed at a temperature of 15° C. or more and 50° C. or less and the mixture is separated into an organic layer and an aqueous layer. In the mixed organic solvent, a ratio of solvent I is from 25 to 60% by mass, and a ratio of solvent II is from 75 to 40% by mass. Solvent I is a hydrocarbon, solvent II is a halogenated hydrocarbon, a mixing ratio Y (organic solvent I/organic solvent II), a temperature T (° C.) at mixing and a weight average molecular weight M of the compound satisfy a relationship of 3.11×10?6M+0.084?Y?0.0135T??1.77×10?6M+0.404.Type: GrantFiled: March 22, 2018Date of Patent: August 25, 2020Assignee: NOF CORPORATIONInventors: Midori Hirai, Hiroki Yoshioka
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Publication number: 20200079905Abstract: A purification method of a polyethylene glycol compound having one carboxyl group. In the method, an aqueous solution of the compound having a pH of 8 to 11 is prepared, the aqueous solution and a mixed organic solvent are mixed at a temperature of 15° C. or more and 50° C. or less and the mixture is separated into an organic layer and an aqueous layer. In the mixed organic solvent, a ratio of solvent I is from 25 to 60% by mass, and a ratio of solvent II is from 75 to 40% by mass. Solvent I is a hydrocarbon, solvent II is a halogenated hydrocarbon, a mixing ratio Y (organic solvent I/organic solvent II), a temperature T (° C.) at mixing and a weight average molecular weight M of the compound satisfy a relationship of 3.11×10?6M+0.084?Y?0.0135T??1.77×10?6M+0.404.Type: ApplicationFiled: March 22, 2018Publication date: March 12, 2020Applicant: NOF CORPORATIONInventors: Midori HIRAI, Hiroki Yoshioka
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Patent number: 9908971Abstract: A multi-arm polyethylene glycol derivative having a narrow molecular weight distribution represented by the formula (1): wherein, L represents a group selected from a linear or branched alkylene, arylene, or cycloalkylene group having two or more carbon atoms and combinations thereof, which may have an ether bond in a chain; X represents a dehydroxylation residue of a linear sugar alcohol having 5 or 7 carbon atoms; m is the number of polyethylene glycol chains bonded to X and represents 4 or 6; n is the average addition molar number of oxyethylene groups and represents an integer of 3 to 600; Y represents a single bond or an alkylene group as further defined herein; and Z represents a chemically reactive functional group.Type: GrantFiled: July 21, 2016Date of Patent: March 6, 2018Assignee: NOF CORPORATIONInventors: Hiroki Yoshioka, Midori Hirai, Hitoshi Nakatsuhara, Yuji Yamamoto
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Publication number: 20160326317Abstract: A multi-arm polyethylene glycol derivative having a narrow molecular weight distribution represented by the formula (1): wherein, L represents a group selected from a linear or branched alkylene, arylene, or cycloalkylene group having two or more carbon atoms and combinations thereof, which may have an ether bond in a chain; X represents a dehydroxylation residue of a linear sugar alcohol having 5 or 7 carbon atoms; m is the number of polyethylene glycol chains bonded to X and represents 4 or 6; n is the average addition molar number of oxyethylene groups and represents an integer of 3 to 600; Y represents a single bond or an alkylene group as further defined herein; and Z represents a chemically reactive functional group.Type: ApplicationFiled: July 21, 2016Publication date: November 10, 2016Applicant: NOF CORPORATIONInventors: Hiroki YOSHIOKA, Midori HIRAI, Hitoshi NAKATSUHARA, Yuji YAMAMOTO
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Patent number: 9458292Abstract: A method for purifying a polyethylene glycol compound having one amino group, which includes (A) preparing an aqueous solution of the compound having a pH of 1 to 5, (B) an extracting step of mixing the aqueous solution with a mixed organic solvent to cause layer separation into organic and aqueous layers, wherein a ratio of an organic solvent I is 25 to 65% by mass and a ratio of an organic solvent II is 75 to 35% by mass, the organic solvent I is selected from an aromatic hydrocarbon and an ester, the organic solvent II is a halogenated hydrocarbon, and a mixing ratio Y of I to II, temperature T (° C.) at mixing, and molecular weight M of the compound satisfy the following relationship: 1.9×10?6M+0.09?Y?0.015T??1.4×10?6M+0.44 and (C) recovering the compound from the aqueous layer.Type: GrantFiled: March 24, 2014Date of Patent: October 4, 2016Assignee: NOF CORPORATIONInventors: Hiroki Yoshioka, Shingo Kimura, Midori Hirai
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Patent number: 9428609Abstract: Provided is a multi-arm polyethylene glycol derivative having a narrow molecular weight distribution. A multi-arm polyethylene glycol derivative represented by the formula (1): m[Z—YnCH2CH2OX—O-L-O—XOCH2CH2nY—Z]m??(1) wherein, L represents a group selected from a linear or branched alkylene, arylene, or cycloalkylene group having two or more carbon atoms and combinations thereof, which may have an ether bond in a chain; X represents a dehydroxylation residue of a linear sugar alcohol having 5 or 7 carbon atoms; m is the number of polyethylene glycol chains bonded to X and represents 4 or 6; n is the average addition molar number of oxyethylene groups and n represents an integer of 3 to 600; Y represents a single bond or an alkylene group which may have an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a secondary amino group, a urea bond, a thioether bond or a thioester bond in a chain or at an end; and Z represents a chemically reactive functional group.Type: GrantFiled: March 28, 2013Date of Patent: August 30, 2016Assignee: NOF CORPORATIONInventors: Hiroki Yoshioka, Midori Hirai, Hitoshi Nakatsuhara, Yuji Yamamoto
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Publication number: 20160046762Abstract: A method for purifying a polyethylene glycol compound having one amino group, which includes (A) preparing an aqueous solution of the compound having a pH of 1 to 5, (B) an extracting step of mixing the aqueous solution with a mixed organic solvent to cause layer separation into organic and aqueous layers, wherein a ratio of an organic solvent I is 25 to 65% by mass and a ratio of an organic solvent II is 75 to 35% by mass, the organic solvent I is selected from an aromatic hydrocarbon and an ester, the organic solvent II is a halogenated hydrocarbon, and a mixing ratio Y of I to II, temperature T (° C.) at mixing, and molecular weight M of the compound satisfy the following relationship: 1.9×10?6M+0.09?Y?0.015T??1.4×10?6M+0.44 and (C) recovering the compound from the aqueous layer.Type: ApplicationFiled: March 24, 2014Publication date: February 18, 2016Applicant: NOF CORPORATIONInventors: Hiroki YOSHIOKA, Shingo KIMURA, Midori HIRAI
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Publication number: 20150073155Abstract: Provided is a multi-arm polyethylene glycol derivative having a narrow molecular weight distribution. A multi-arm polyethylene glycol derivative represented by the formula (1): m[Z—Yn?CH2CH2O??X—O-L-O—X??OCH2CH2?nY—Z]m??(1) wherein, L represents a group selected from a linear or branched alkylene, arylene, or cycloalkylene group having two or more carbon atoms and combinations thereof, which may have an ether bond in a chain; X represents a dehydroxylation residue of a linear sugar alcohol having 5 or 7 carbon atoms; m is the number of polyethylene glycol chains bonded to X and represents 4 or 6; n is the average addition molar number of oxyethylene groups and n represents an integer of 3 to 600; Y represents a single bond or an alkylene group which may have an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a secondary amino group, a urea bond, a thioether bond or a thioester bond in a chain or at an end; and Z represents a chemically reactive functional group.Type: ApplicationFiled: March 28, 2013Publication date: March 12, 2015Applicant: NOF CORPORATIONInventors: Hiroki Yoshioka, Midori Hirai, Hitoshi Nakatsuhara, Yuji Yamamoto