Abstract: Tests regarding chromosomal abnormalities in pluripotent stem cells have involved cellular invasion, and have been unable to be applied to cells that require non-invasive testing, such as cells being cultured. Provided is an information processing system including: an image data acquisition unit configured to acquire image data including a colony of pluripotent stem cells; a first information acquisition unit configured to acquire, based on analysis of the image data, first information that is information regarding a predetermined morphology of the colony of pluripotent stem cells; and a second information generation unit configured to generate, based on the first information, second information that is information regarding chromosomal abnormalities in the pluripotent stem cells.

Abstract: An information processing system, comprises: an image data acquiring section that acquires image data including a colony of pluripotent stem cells; a first information acquiring section that acquires first information regarding morphological features of the colony by inputting the image data to a learned model; and a second information acquiring section that acquires second information regarding a chromosomal aberration of the colony based on the first information. The learned model is obtained by learning with a dataset including image data of a plurality of colonies of pluripotent stem cells having a chromosomal aberration and image data of a plurality of colonies of pluripotent stem cells not having a chromosomal aberration.

Abstract: An information acquisition method including: an image acquisition step of acquiring a plurality of cell images photographed at a plurality of different photographing timings; a live cell region determination step of determining whether a cell region present in each of the plurality of cell images is a live cell region including a live cell; a tracking step of performing association of live cell regions derived from the same cell region which are respectively present in the plurality of cell images photographed at the plurality of different photographing timings with each other while tracing back in time to the first timing starting from a live cell region present in the cell image photographed at the second timing; and a viability determination step of determining that a live cell region successfully tracked in the tracking step among cell regions present in the cell image photographed at the first timing exhibits viability.

Abstract: Provided is a method of stably reprogramming a cell. Provided is an information processing method for reprogramming of a blood cell, the information processing method including an autofluorescence information acquisition step of acquiring autofluorescence information on a subject blood cell and an analysis step of performing analysis based on the autofluorescence information and cell information on the subject blood cell, in which the cell information includes identification information on the blood cell.

Abstract: Provided is a nucleic acid detection apparatus including: a distribution unit configured to distribute a sample and a detection reagent to a plurality of individual independent separated compartments, the sample containing a target nucleic acid, and the detection reagent containing an effector protein, crRNA to be bound to the target nucleic acid, and a reporter molecule; an activation unit configured to activate the effector protein through binding of the crRNA to the target nucleic acid; a fluorescence generation unit configured to modify the reporter molecule with the activated effector protein to generate fluorescence; a fluorescence detection unit configured to detect the fluorescence; and an identification unit configured to determine, based on a detection result obtained with the fluorescence detection unit, a fluorescence intensity of each of the individual independent separated compartments, and to identify each of the individual independent separated compartments having a fluorescence intensity exce

Abstract: A detection method for a target nucleic acid comprising: a first step of contacting a target nucleic acid with a first guide RNA and a first Cas protein; a second step of contacting the target nucleic acid with a second guide RNA and a second Cas protein; and a third step of detecting a complex comprising the target nucleic acid, the first guide RNA, the first Cas protein, the second guid RNA, and the second Cas protein, wherein, in the complex, the first guide RNA and the first Cas protein are bound to the first base sequence, and the second guide RNA and the second Cas protein are bound to the second base sequence.

Abstract: An object information acquiring apparatus includes: an optical image acquiring unit which acquires an optical image obtained by optically capturing an image of an object on which a marker is arranged; a photoacoustic image acquiring unit which acquires a photoacoustic image derived from a photoacoustic wave generated from the object irradiated with light; and a superimposed image generating unit which generates a graphic on the basis of positional information of the marker in the optical image and which generates a superimposed image by superimposing the graphic onto the photoacoustic image.

Abstract: An object information acquiring apparatus, comprises a light irradiating unit configured to irradiate an object with light; a probe configured to receive an acoustic wave generated from the object and convert into an electrical signal; a characteristic information acquiring unit configured to acquire characteristic information relating to the object based on the electrical signal; an area information acquiring unit configured to acquire information relating to a reachable area of the light; a location detecting unit configured to acquire an operator location; and a determining unit configured to determine whether the operator location is in a first state where the operator location overlaps with the reachable area of the light or a second state where the operator location does not overlap with the reachable area of the light.

Abstract: Employed is an information processing apparatus, comprising: an interpretation result acquiring unit configured to acquire a plurality of pieces of interpretation result information resulting from interpretations by a plurality of interpreters of a photoacoustic image originating from photoacoustic waves produced from an object that has been irradiated with light; an interpreter information acquiring unit configured to acquire interpreter information that is information pertaining to the plurality of interpreters; and an information processing unit configured to, based on the interpreter information, acquire information identifying each of the interpreters that performed interpretations corresponding respectively to the plurality of pieces of interpretation result information, and configured to, using this interpreter-identifying information, perform weighting of the plurality of pieces of interpretation result information.

Abstract: Provided is an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue. Also provided is an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability. Also provided is a screening method using an evaluation probe for central nervous system permeability. The evaluation probe for central nervous system permeability includes, as an active ingredient, at least one kind of compound represented by the following general formula (1).

Abstract: An object information acquiring apparatus, comprises a light irradiating unit configured to irradiate an object with light; a probe configured to receive an acoustic wave generated from the object and convert into an electrical signal; a characteristic information acquiring unit configured to acquire characteristic information relating to the object based on the electrical signal; an area information acquiring unit configured to acquire information relating to a reachable area of the light; a location detecting unit configured to acquire an operator location; and a determining unit configured to determine whether the operator location is in a first state where the operator location overlaps with the reachable area of the light or a second state where the operator location does not overlap with the reachable area of the light.

Abstract: An apparatus according to the present invention includes: a conversion element for converting an acoustic wave generated from an object when irradiated with light, to a reception signal; a signal processing unit for acquiring specific information of the object using the reception signal; a status measuring unit for measuring a status of placement of the object; a determining unit for determining whether the object is placed at an appropriate position for a photoacoustic measurement using a measurement result of the status measuring unit; and a noticing unit for noticing a method of moving the object on the basis of a determination result of the determining unit.

Abstract: To provide a central nervous system tissue-labeling composition labeling the central nervous tissue system. Also, another object of the present invention is to provide a method for non-invasively labeling the central nervous tissue system. Further, another object of the present invention is to provide a screening method using the above central nervous system tissue-labeling composition. A central nervous system tissue-labeling composition containing, as an active ingredient, at least one of compounds represented by the general formula (1) or (7).

Abstract: The present invention provides a hematopoietic stem cell identification probe.

Abstract: The present invention provides a hematopoietic stem cell identification probe.

Abstract: To provide a central nervous system tissue-labeling composition labeling the central nervous tissue system. Also, another object of the present invention is to provide a method for non-invasively labeling the central nervous tissue system. Further, another object of the present invention is to provide a screening method using the above central nervous system tissue-labeling composition. A central nervous system tissue-labeling composition containing, as an active ingredient, at least one of compounds represented by the general formula (1) or (7).

Abstract: Provided is an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue. Also provided is an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability. Also provided is a screening method using an evaluation probe for central nervous system permeability. The evaluation probe for central nervous system permeability includes, as an active ingredient, at least one kind of compound represented by the following general formula (1).

Abstract: To provide a central nervous system tissue-labeling composition labeling the central nervous tissue system. Also, another object of the present invention is to provide a method for non-invasively labeling the central nervous tissue system. Further, another object of the present invention is to provide a screening method using the above central nervous system tissue-labeling composition. A central nervous system tissue-labeling composition containing, as an active ingredient, at least one of compounds represented by the general formula (1) or (7).

Abstract: A target substance detection method for detecting a target substance in a specimen, comprises the steps of contacting with a specimen a target substance detecting element comprised of a base, a metal structure and a first capturing body for capturing a target substance; contacting with the target substance detecting element a labeling material comprised of a labeling substance and a second capturing body for capturing a target substance; and acquiring an absorption spectrum (A) of the target substance detecting element contacted with the specimen and the labeling material, wherein the employed labeling substance is a substance that a slope of a tangent of an absorption spectrum (C) of the labeling substance at a peak wavelength (?z) of an absorption spectrum (B) of the target substance detecting element is larger than zero.

Abstract: A target substance detection method for detecting a target substance in a specimen, comprises the steps of contacting with a specimen a target substance detecting element comprised of a base, a metal structure and a first capturing body for capturing a target substance; contacting with the target substance detecting element a labeling material comprised of a labeling substance and a second capturing body for capturing a target substance; and acquiring an absorption spectrum (A) of the target substance detecting element contacted with the specimen and the labeling material, wherein the employed labeling substance is a substance that a slope of a tangent of an absorption spectrum (C) of the labeling substance at a peak wavelength (?z) of an absorption spectrum (B) of the target substance detecting element is larger than zero.