Patents by Inventor Mieke Sibeijn

Mieke Sibeijn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolation of carotenoid crystals
    Patent number: 7015014
    Abstract: The present invention relates to a crystalline carotenoid compound, such as ?-carotene, with a purity of at least 95% and with substantially no solvent enclosed in the crystal lattice. The present invention further describes a process to prepare such a highly pure crystalline carotenoid compound from microbial biomass, without the use of a solvent extraction and/or an anti-solvent crystallization process.
    Type: Grant
    Filed: January 29, 2001
    Date of Patent: March 21, 2006
    Assignee: DSM IP Assets B.V.
    Inventors: Albert Schaap, Mieke Sibeijn, Johannes Hendrik Wolf
  • Isolation of carotenoid crystals from microbial biomass
    Patent number: 6812001
    Abstract: A process for the isolation of crystalline carotenoid compound from microbial biomass comprising disrupting the microbial cell walls, separating cellular debris from the carotenoid-containing residue, washing one member of the group consisting of the microbial biomass, the disrupted cell mass and the carotenoid-containing reside with a solvent to remove lipid, suspending the obtained carotenoid crystals in water to float the crystals, recovering the crystals and, optionally, further purifying the crystals which avoids the use of large amounts of solvent of carotenoid extraction process.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: November 2, 2004
    Assignee: DSM N.V.
    Inventors: Mieke Sibeijn, Robertus Mattheus De Pater
  • Isolation of cartenoid crystals
    Publication number: 20030139480
    Abstract: The present invention relates to a crystalline carotenoid compound, such as &bgr;-carotene, with a purity of at least 95% and with substantially no solvent enclosed in the crystal lattice. The present invention further describes a process to prepare such a highly pure crystalline carotenoid compound from microbial biomass, without the use of a solvent extraction and/or an anti-solvent crystallization process.
    Type: Application
    Filed: July 29, 2002
    Publication date: July 24, 2003
    Inventors: Mieke Sibeijn, Johannes Hendrik Wolf, Albert Schaap
  • Isolation of carotenoid crystals from microbial biomass
    Publication number: 20020055135
    Abstract: A process for the isolation of crystalline carotenoid compound from microbial biomass comprising disrupting the microbial cell walls, separating cellular debris from the carotenoid-containing residue, washing one member of the group consisting of the microbial biomass, the disrupted cell mass and the carotenoid-containing reside with a solvent to remove lipid, suspending the obtained carotenoid crystals in water to float the crystals, recovering the crystals and, optionally, further purifying the crystals which avoids the use of large amounts of solvent of carotenoid extraction process.
    Type: Application
    Filed: December 20, 2001
    Publication date: May 9, 2002
    Inventors: Mieke Sibeijn, Robertus Mattheus De Pater
  • HMG-CoA reductase inhibitor preparation process
    Patent number: 6268186
    Abstract: The invention provides a simple and selective method for the deacylation of 4-acylated statins during the preparation of statins from a fermentation broth, more specifically a reduction of impurities from the process, by increasing the pH of the fermentation broth.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: July 31, 2001
    Assignee: DSM N.V.
    Inventors: Mieke Sibeijn, Aad Johannes Bouman, Robertus Mattheus De Pater, Cornelis Frederik Purmer