Abstract: This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) of Neisseria meningitidis in solutions containing fully synthetic variants of the GM3 ganglioside.

Abstract: Embodiments of the disclosure include methods and compositions for treating or preventing acute inflammation using soluble vimentin. In specific embodiments, a vimentin derivative comprising the rod domain is utilized for treating or preventing any disease in which a decrease in leukocyte adhesion is therapeutic. In specific embodiments, a fragment of vimentin that comprises part or all of the rod domain is employed.

Abstract: Embodiments of the disclosure include methods and compositions for treating or preventing acute inflammation using soluble vimentin. In specific embodiments, a vimentin derivative comprising the rod domain is utilized for treating or preventing any disease in which a decrease in leukocyte adhesion is therapeutic. In specific embodiments, a fragment of vimentin that comprises part or all of the rod domain is employed.

Abstract: The present invention is directed to methods for the prevention, treatment and/or diagnosis of a medical condition, such as sepsis, systemic inflammatory reaction syndrome, and/or thrombosis, for example. In particular, the method employs part or all of the A2 domain of von Willebrand factor. In certain cases, a recombinant A2 domain is utilized for the treatment of sepsis, systemic inflammatory reaction syndrome, and/or thrombosis, for example.

Abstract: The present invention is directed to methods for the prevention, treatment and/or diagnosis of a medical condition, such as sepsis, systemic inflammatory reaction syndrome, and/or thrombosis, for example. In particular, the method employs part or all of the A2 domain of von Willebrand factor. In certain cases, a recombinant A2 domain is utilized for the treatment of sepsis, systemic inflammatory reaction syndrome, and/or thrombosis, for example.

Abstract: The present invention is directed to an assay for ADAMTS-13 activity. The assay provides rapid analysis of ADAMTS-13 activity in a biological sample under non-denaturing conditions. Furthermore, the present invention is directed to a recombinant polypeptide with a functional ADAMTS-13 site that is useful in ADAMTS-13 activity assays.