Abstract: The present disclosure is directed towards devices, methods, and related systems that are minutely-invasively delivered to the brain parenchyma, subdural or subarachnoid space where the devices, methods, and systems directly interface with central nervous system media (i.e., fluid or tissue) enabling detecting, sensing, measuring, stimulating, altering and/or modulating of the media or tissue surfaces.

Abstract: The present disclosure discusses a devices, systems and methods for transvascular, transvenous and/or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device/component delivery/insertion/implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

Abstract: A cleaning apparatus having a door assembly sealable against the door opening of the sterilizing machine by an inflatable seal connected to an air chuck on the cleaning apparatus is operable to descale a sterilizing machine. The cleaning apparatus includes separate tanks for storing and dispensing cleaning fluid and rinse fluid. A pump associated with each tank sends fluid into the spray wand for distribution within the sterilizer machine. A vacuum is created within the corresponding tank and to draw fluid from the sterilizer machine back into the selected tank. The spray wand can be moved linearly and rotationally to direct the fluid throughout the interior of the sterilizing machine with the fluid being recycled back into the tank through a vacuum port. A selector valve on the cleaning apparatus allows the selection of cleaning fluid or rinse fluid to be drawn into the sterilizing machine.

Abstract: The present disclosure is directed towards devices, methods, and related systems that are minutely-invasively delivered to the brain parenchyma, subdural or subarachnoid space where the devices, methods, and systems directly interface with central nervous system media (i.e., fluid or tissue) enabling detecting, sensing, measuring, stimulating, altering and/or modulating of the media or tissue surfaces.

Abstract: The present disclosure is directed towards devices, methods, and related systems that are minutely-invasively delivered to the brain parenchyma, subdural or subarachnoid space where the devices, methods, and systems directly interface with central nervous system media (i.e., fluid or tissue) enabling detecting, sensing, measuring, stimulating, altering and/or modulating of the media or tissue surfaces.

Abstract: The present disclosure discusses a devices, systems and methods for transvascular, transvenous and/or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device/component delivery/insertion/implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

Abstract: The present disclosure is directed towards devices, methods, and related systems that are minutely-invasively delivered to the brain parenchyma, subdural or subarachnoid space where the devices, methods, and systems directly interface with central nervous system media (i.e., fluid or tissue) enabling detecting, sensing, measuring, stimulating, altering and/or modulating of the media or tissue surfaces.

Abstract: The present disclosure discusses a devices, systems and methods for transvascular, transvenous and/or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device/component delivery/insertion/implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

Abstract: The present disclosure discusses a devices, systems and methods for transvascular, transvenous and/or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device/component delivery/insertion/implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

Abstract: Systems, methods, and computer-readable media are disclosed for voice activated devices with integrated heatsinks and speakers. In one embodiment, an example voice activated device may include a housing having an upper portion and a lower portion, a speaker housing coupled to the lower portion, where the speaker housing and the lower portion together form a sealed chamber, a heatsink coupled to the lower portion and disposed in the sealed chamber, and a first speaker coupled to the speaker housing and partially disposed within the sealed chamber, where the first speaker is oriented to output audio towards the upper portion of the housing.

Abstract: A system and method for recording and verifying the data integrity, identity of the recorder, and no-later-than date-of-existence for digital content of an arbitrary size is provided. The provided system and method employ blockchain technology to ensure immutability and accessibility of digital content state, digital content recorder identity, and timestamp of recording for the recorded digital content. The provided system and method also generate meta-data files associated with the recorded digital content that consist of a manifest file, a signature file, and a signature block file. The meta-data files are included into the digital content in order to facilitate the verification of the digital content against the records held in the blockchain.

Abstract: The present disclosure discusses a devices, systems and methods for transvascular, transvenous and/or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device/component delivery/insertion/implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

Abstract: A compressible element for a sensor assembly includes an elastomer matrix having a first compressibility and a plurality of closed areas distributed within the elastomer matrix and each surrounded by the elastomer matrix. Each of the closed areas has a second compressibility greater than the first compressibility.

Abstract: Systems, methods, and computer-readable media are disclosed for voice activated devices with integrated heatsinks and speakers. In one embodiment, an example voice activated device may include a housing having an upper portion and a lower portion, a speaker housing coupled to the lower portion, where the speaker housing and the lower portion together form a sealed chamber, a heatsink coupled to the lower portion and disposed in the sealed chamber, and a first speaker coupled to the speaker housing and partially disposed within the sealed chamber, where the first speaker is oriented to output audio towards the upper portion of the housing.

Abstract: A compressible element for a sensor assembly includes an elastomer matrix having a first compressibility and a plurality of closed areas distributed within the elastomer matrix and each surrounded by the elastomer matrix. Each of the closed areas has a second compressibility greater than the first compressibility.

Abstract: A system and method for recording and verifying the data integrity, identity of the recorder, and no-later-than date-of-existence for digital content of an arbitrary size is provided. The provided system and method employ blockchain technology to ensure immutability and accessibility of digital content state, digital content recorder identity, and timestamp of recording for the recorded digital content. The provided system and method also generate meta-data files associated with the recorded digital content that consist of a manifest file, a signature file, and a signature block file. The meta-data files are included into the digital content in order to facilitate the verification of the digital content against the records held in the blockchain.

Abstract: A method and system for detecting, manipulating and isolating circulating tumor cells found in organic fluids comprising a simplified laser assisted transfer process. A liquid specimen of the organic fluid containing an enriched population of tumor cells and a population of non-tumor cells is spread onto a donor substrate with an interlayer comprising a semi-transparent polymeric adhesive tape. A fluorescent staining of at least one of the cell populations present in the liquid specimen is required to identify-using optical and fluorescence microscopy, the location of the cells to be manipulated and/or isolated. The laser beam energy is absorbed by the polymeric adhesive tape giving place to the formation of a blister that mechanically interacts with the liquid specimen and such interaction can induce the expulsion of a portion of the liquid specimen comprising the selected tumor cells or non-tumor cells, which can be a single cell or a cell cluster, towards the receiving substrate.

Abstract: A method of forming a conductive trace that includes steps of A) selecting a substrate, B) providing a jet dispenser, C) selecting a conductive ink, D) measuring the ink's viscosity (Vm), E) using Vm to select one of criteria (i)-(iv), F) applying the selected criteria to the dispenser, and G) applying the ink onto the substrate; and drying, curing, or annealing the ink to form the conductive trace having ?4B adhesion. The criteria (i)-(iv) include: (i) (Vm) >2.0 Pa-s, then (1) add a fluid—repeat D)-E) or (2) repeat C)-E); (ii) 2.0 Pa-s?Vm>0.35 Pa-s, use needle diameter ?3.0 mm & nozzle diameter (d) ?0.15 mm with ratio of nozzle length (L) to nozzle diameter (d) ?30; (iii) Vm<0.25 Pa-s, use a needle diameter ?1.0 mm and <3.0 mm & nozzle diameter ?0.15 mm with L/d ?30; or (iv) 0.25 Pa-s?Vm?0.35 Pa-s, use criteria (ii) or (iii).

Abstract: Methods and systems are provided for a dry silicone gel. The dry silicone gel comprises a base polymer having a vinyl-silicone group, a crosslinker, and a chain extender. The dry silicone gel may be made by reacting (a) a first set of components comprising a base polymer having a vinyl-silicone group and an addition cure catalyst with (b) a second set of components comprising a crosslinker, a chain extender, and additional base polymer. In certain circumstances, the base polymer and additional base polymer are vinyl-terminated polydimethylsiloxane.

Abstract: Methods and systems are provided for a dry silicone gel. The dry silicone gel comprises a base polymer having a vinylsilicone group, a crosslinker, and a chain extender. The dry silicone gel may be made by reacting (a) a first set of components comprising a base polymer having a vinylsilicone group and an addition cure catalyst with (b) a second set of components comprising a crosslinker, a chain extender, and additional base polymer. In certain circumstances, the base polymer and additional base polymer are vinyl-terminated polydimethylsiloxane.