Patents by Inventor Miguel A. Pappolla

Miguel A. Pappolla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indole-3-propionamide and derivatives thereof
    Publication number: 20070105937
    Abstract: Indolepropionamide (IPAM) and related compounds, pharmaceutical or dietary compositions thereof and methods of using said compounds are disclosed for use as a preventative or therapeutic treatment for many conditions related to oxidative damage. Oxidative damage increases in aging and age related disorders and is widespread in many neurodegenerative conditions including Alzheimer's disease, Parkinson's disease and others. Indolepropionamide is a potent anti-oxidant and anti-aging molecule, with superior properties as compares to previously known compounds.
    Type: Application
    Filed: December 21, 2004
    Publication date: May 10, 2007
    Inventors: Miguel Pappolla, Burkhard Poeggeler
  • Uses for indole-3-propionic acids and salts and esters thereof
    Patent number: 6395768
    Abstract: The cytotoxic effects of amyloid beta protein on cells are prevented by contacting the cells with an effective amount of an indole-3-propionic acid or a salt or ester thereof. Furthermore, a fibrillogenic disease can be treated in a human subject by administering to the human subject an amount of-an indole-3-propionic acid or a salt or ester thereof effective to prevent or reverse fibrillogenesis. Oxidation in a biological sample can be decreased by contacting the biological sample with an effective amount of an indole-3-propionic acid or a salt or ester thereof. Additionally, diseases or other conditions where free radicals and/or oxidative stress play a role can be treated by administering an effective amount of an indole-3-propionic acid or a salt or ester thereof.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: May 28, 2002
    Assignees: South Alabama Medical Science Foundation, New York University
    Inventors: Miguel A. Pappolla, Blas Frangione, Jorge Ghiso, Burkhard Poeggeler
  • Method for delaying the onset of alheimer's disease and for treatment or delaying the onset of other amyloidosis-related diseases/disorders
    Patent number: 6274615
    Abstract: The present invention relates to a method of using melatonin to reduce, inhibit or reverse the formation of amyloid fibrils and amyloid or amyloid-like deposits. The present invention also relates to a method for delaying the onset of Alzheimer's Disease or other amyloidosis-related diseases/disorders or for treating such diseases/disorders by administering an effective amount of melatonin to a subject in need thereof.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: August 14, 2001
    Assignees: South Alabama Medical Science Foundation, New York University
    Inventors: Miguel A. Pappolla, Blas Frangione, Jorge Ghiso
  • Use of melatonin to prevent cytotoxic effects of amyloid beta protein
    Patent number: 5958964
    Abstract: The present invention is directed to a method of preventing cytotoxic effects of amyloid beta protein on cells. The method comprises exposing the cells to an effective amount of melatonin. The invention further provides a method of treating Alzheimer's disease in a human subject, which comprises administering an amount of melatonin effective to prevent the cytotoxic effects of amyloid beta protein to the human subject.
    Type: Grant
    Filed: February 18, 1997
    Date of Patent: September 28, 1999
    Assignee: South Alabama Medical Science Foundation
    Inventor: Miguel A. Pappolla