Patents by Inventor Miguel Angel Ondetti

Miguel Angel Ondetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolidine and piperidine-2-carboxylic acid derivatives
    Patent number: 4116962
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 3, 1976
    Date of Patent: September 26, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel Angel Ondetti, Frank Lee Weisenborn
  • Amino acid derivatives
    Patent number: 4113715
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.SUMMARY OF THE INVENTIONThis invention relates to new substituted acyl derivatives of amino acids which have the general formula ##STR2## and salts thereof,WHEREIN R is hydroxy or lower alkoxy;R.sub.1 is hydrogen, lower alkanoyl or amino(imino)methyl;R.sub.2 is hydrogen, lower alkyl or phenyl-lower alkylene;R.sub.3 is hydrogen, lower alkanoyl, benzoyl or ##STR3##A is hydrogen, lower alkyl or hydroxy-lower alkylene;B is hydrogen, lower alkyl, phenyl, phenyl-lower alkylene, hydroxy-lower alkylene, hydroxyphenyl-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkyl-thio-lower alkylene, imidazolyl-lower alkylene, indolyl-lower alkylene, carbamoyl-lower alkylene or carboxy-lower alkylene;OR A and B together form a (CH.sub.2).sub.
    Type: Grant
    Filed: January 17, 1977
    Date of Patent: September 12, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel Angel Ondetti, Michael Edward Condon
  • Method for alleviating angiotensin related hypertension
    Patent number: 4112119
    Abstract: A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting enzyme inhibitor selected from a group of mercaptoacyl aminoacids.
    Type: Grant
    Filed: March 3, 1977
    Date of Patent: September 5, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel Angel Ondetti, David W. Cushman
  • Thiopropanoylamino acid derivatives
    Patent number: 4108886
    Abstract: New thiopropanoylamino acid derivatives which have the formula ##STR1## wherein R and R.sub.1 each is lower alkyl;R.sub.2 and R.sub.3 each is hydrogen or lower alkyl; or R.sub.1 can be joined to either R or to R.sub.2 in a five membered ring;R.sub.4 is hydrogen, lower alkanoyl or benzoyl;Are useful as hypotensive agents.
    Type: Grant
    Filed: March 11, 1977
    Date of Patent: August 22, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Miguel Angel Ondetti
  • Carboxyalkylacylamino acids
    Patent number: 4105789
    Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: May 10, 1976
    Date of Patent: August 8, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel Angel Ondetti, David W. Cushman
  • Proline derivatives and related compounds
    Patent number: 4105776
    Abstract: New proline derivatives and related compounds which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: August 8, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel Angel Ondetti, David W. Cushman
  • Pyrrolidine and piperidine-2-carboxylic acid derivatives
    Patent number: 4091024
    Abstract: New derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 3, 1976
    Date of Patent: May 23, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Miguel Angel Ondetti
  • N-carboxyalkanoyl derivatives of azetidine-2-carboxylic acid
    Patent number: 4086338
    Abstract: New carboxyalkylacylamino acids which are derivatives of proline, pipecolic acid and azetidine-2-carboxylic acid and have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: February 11, 1977
    Date of Patent: April 25, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David W. Cushman, Miguel Angel Ondetti
  • Compounds and method for alleviating angiotensin related hypertension
    Patent number: 4053651
    Abstract: A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting enzyme inhibitor selected from a group of mercaptoacyl aminoacids.
    Type: Grant
    Filed: May 10, 1976
    Date of Patent: October 11, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel Angel Ondetti, David W. Cushman
  • Carboxyacylproline derivatives
    Patent number: 4052511
    Abstract: New carboxyalkylacylamino acids which are derivatives of proline, pipecolic acid and azetidine-2-carboxylic acid and have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: February 13, 1976
    Date of Patent: October 4, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David W. Cushman, Miguel Angel Ondetti
  • Azetidine-2-carboxylic acid derivatives
    Patent number: 4046889
    Abstract: New proline derivatives and related compounds which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: February 13, 1976
    Date of Patent: September 6, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel Angel Ondetti, David W. Cushman
  • Pyrrolidine derivatives
    Patent number: 3976660
    Abstract: Pyrrolidine derivatives which have the formula ##SPC1##Wherein R and R.sub.1 each is hydrogen, --(CH.sub.2).sub.6 COOH, --(CH.sub.2).sub.6 COO-- lower alkyl, or --(CH.sub.2).sub.6 COO benzyl and R.sub.2 is hydrogen, --CO--O--(CH.sub.2).sub.5 CH.sub.3, --CO--NH--(CH.sub.2).sub.5 CH.sub.3 --(CH.sub.2).sub.7 CH.sub.3 or --CH=CH--CH(OH)--(CH.sub.2).sub.4 --CH.sub.3, at least one of R and R.sub.1 is hydrogen and R.sub.1 and R.sub.2 are not both hydrogen, are new compounds which are useful as inhibitors of prostaglandin dehydrogenase and as potentiators of prostaglandin activity.
    Type: Grant
    Filed: August 15, 1974
    Date of Patent: August 24, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel Angel Ondetti, Edward Condon
  • Peptide enzyme inhibitors of angiotensin I
    Patent number: 3973006
    Abstract: Ester and amides of the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro have been found to inhibit the hypertensive effect of angiotensin I.
    Type: Grant
    Filed: February 21, 1975
    Date of Patent: August 3, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Miguel Angel Ondetti
  • Method of stabilizing an injectable composition of a cholecystokinin active octapeptide
    Patent number: 3937819
    Abstract: A stable composition of the sulfated octapeptide, ##EQU1## having cholecystokinin activity, is obtained by lyophilizing an aqueous solution of the octapeptide and NaCl.
    Type: Grant
    Filed: July 22, 1974
    Date of Patent: February 10, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel Angel Ondetti, Charles Riffkin, Bernard Rubin, Aaron L. Weiss