Abstract: An injection capsule for medical use, having: a closed main body having an internal reservoir receiving a medical substance in liquid form to be administered to a target subject; and a needle, having one or more inlet bores located at its lateral skirt and configured to allow the inlet of the medical substance within its tubular body. The needle is activatable between a rest configuration, wherein it is housed within the reservoir and immersed in the medical substance, and an injection configuration, wherein it is pushed outside the closed main body to administer the medical substance by injection to the target subject.

Abstract: Disclosed is a medicament dispenser (1) for delivering a medicament (9, 53) to a user (2), the medical dispenser (1) comprising one or more internal storages (3, 52) for storing one or more medicaments (9, 53); a dispensing unit (10, 101) configured to access said one or more internal storages (3, 52) and dispense the medicament (9; 53) based on a predefined dispensing protocol (18); a control unit (13) comprising a user recognition unit (12, 19), adapted to collect user authentication data (76); and a communication module (14), configured to send/receive said user authentication data (76) and a delivery control data (16) associated to said predefined dispensing protocol (18) to/from a remote server (15); wherein said control unit 5 (13) is configured to enable/disable said dispensing unit (10, 101) based on said user authentication data (76) and said delivery control data (16).

Abstract: Disclosed is a medicament dispenser (1) for delivering a medicament (9, 53) to a user (2), the medical dispenser (1) comprising one or more internal storages (3, 52) for storing one or more medicaments (9, 53); a dispensing unit (10, 101) configured to access said one or more internal storages (3, 52) and dispense the medicament (9; 53) based on a predefined dispensing protocol (18); a control unit (13) comprising a user recognition unit (12, 19), adapted to collect user authentication data (76); and a communication module (14), configured to send/receive said user authentication data (76) and a delivery control data (16) associated to said predefined dispensing protocol (18) to/from a remote server (15); wherein said control unit 5 (13) is configured to enable/disable said dispensing unit (10, 101) based on said user authentication data (76) and said delivery control data (16).

Abstract: Compositions and methods are provided for treating NF-?B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-?B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-?B activation.

Abstract: Compositions and methods are provided for treating NF-?B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-?B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-?B activation.

Abstract: Compositions and methods are provided for treating NF-?B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-?B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-?B activation.

Abstract: Compositions and methods are provided for treating NF-&kgr;B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-&kgr;B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-&kgr;B activation.

Abstract: Compositions and methods are provided for treating NF-&kgr;B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-&kgr;B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-&kgr;B activation.

Abstract: Compositions and methods are provided for treating NF-&kgr;B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-&kgr;B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-&kgr;B activation.

Abstract: Reporter systems for assaying positive sense RNA virus replication are provided. The reporter systems comprise a reporter gene in antisense orientation, flanked by the complements of 5′ and 3′ viral genome ends, such that exposure to an RNA-dependent RNA polymerase results in the generation of mRNA encoding an active reporter protein. Such systems may be used, for example, to detect active RNA virus and to monitor RNA virus therapies.

Abstract: Compositions and methods are provided for treating NF-&kgr;B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-&kgr;B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-&kgr;B activation.

Abstract: Plasmid reporter systems for assaying transcription and replication are provided. The plasmids comprise dual reporters for use in the independent evaluation of transcription and replication. Such plasmids may be used for example, for determining the role of endogenous factors in transcription and replication and for evaluating the effect of exogenous modulators on such processes. Within certain embodiments, the plasmids comprise (a) a first reporter gene operably linked to a promoter and a binding site for human papillomavirus E1 and/or E2 protein; (b) a second reporter gene that is linked to a promoter that is not substantially modulated by E1 and/or E2 and (c) an origin of replication bound by human papillomavirus E1 protein.

Abstract: Compositions and methods are provided for treating NF-.kappa.B-related conditions. In particular, the invention provides a stimulus-inducible I.kappa.B.alpha. kinase complex, and components and variants thereof. I.kappa.B.alpha. kinase complex may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the NF-.kappa.B cascade. I.kappa.B.alpha. kinase complex, components thereof and/or such agents may also be used for the treatment of diseases associated with NF-.kappa.B activation.