Abstract: The present invention is enclosed in the area of machine learning, in particular machine learning for the analysis of High or Super-resolution spectroscopic data, which typically comprises analysis of highly complex samples/mixtures of substances and/or data with low resolution, for instance Laser-Induced Breakdown Spectroscopy (LIBS). It is an object of the present invention a method of computational self-learning for characterization of one or more constituents in a sample, from electromagnetic spectral information of such sample, which changes the paradigm associated with prior art methods, by using only sub-optical spectral information, i.e., obtaining the resolution of the spectral information and thereby be able to extract spectral lines—thus determining a spectral line position—from such spectral information, hence avoiding all the uncertainty associated with pixel based methods. It is also an object of the present invention a computational apparatus configured to implement such method.

Abstract: This disclosure describes a system and method for Head-Related Transfer Function (HRTF) interpolation when an HRTF dataset does not contain a particular direction associated with a desired source. The disclosed HRTF interpolation uses a finite set of HRTFs from a dataset to obtain the HRTF of any possible direction and distance, even if the direction/distance doesn't exist on the current dataset.

Abstract: Biophotonic device for the point-of-care, real-time, non-invasive determination of parameters with diagnostic relevance, in particular an optical system for parameter characterization of an element of body fluid or tissue comprising an optical device which comprises: a light source for emitting light onto the element; and a spectrometer for recording the spectrum of light from the element, said light from the element being of transmittance, reflectance or Raman scattering of the emitted light by said element; the optical system further comprising a data processing module configured to: convert the recorded spectrum by a conversion matrix into a standardized spectrum, wherein said conversion matrix has been obtained by calibrating the optical system spectrum response against a spectrum reference; pre-process the converted spectrum; correlate, for parameter quantification, the converted pre-processed spectrum with pre-obtained spectral bands for each parameter; said spectrum being contained within uv-vis-nir wa

Abstract: The present invention is enclosed in the area of calibration of spectral information/spectroscopy devices, such as the calibration of spectral information which consist of high-resolution electromagnetic spectra, as Laser-induced Breakdown Spectroscopy (LIBS). It is an object of the present invention a calibration method of a spectroscopy device comprising a plurality of sensors and a method for transferring spectral information obtained from a first and a second spectroscopy devices. The method of the present invention provides the access to accurately defined spectral lines from the electromagnetic spectrum, as well as to obtain electromagnetic spectra in two different sites, with two different spectroscopy devices and physical samples still provide for the reliable comparison between the electromagnetic spectra obtained in each of such spectroscopy devices.

Abstract: The present disclosure relates to compositions and pharmaceutical formulations comprising at least one active pharmaceutical ingredient chosen from nitrocatechol derivatives of formula I as defined herein and salts, esters, hydrates, solvates and other derivatives thereof and methods of making the same.

Abstract: The present invention is enclosed in the area of machine learning, in particular machine learning for the analysis of High or Super-resolution spectroscopic data, which typically comprises analysis of highly complex samples/mixtures of substances and/or data with low resolution, for instance Laser-Induced Breakdown Spectroscopy (LIBS). It is an object of the present invention a method of computational self-learning for characterization of one or more constituents in a sample, from electromagnetic spectral information of such sample, which changes the paradigm associated with prior art methods, by using only sub-optical spectral information, i.e., obtaining the resolution of the spectral information and thereby be able to extract spectral lines—thus determining a spectral line position—from such spectral information, hence avoiding all the uncertainty associated with pixel based methods. It is also an object of the present invention a computational apparatus configured to implement such method.

Abstract: The present invention relates to formulations comprising Compound X or a pharmaceutically acceptable salt or solvate thereof: and methods for their preparation.

Abstract: The impact of post-synthesis processing in, for example, graphene oxid or reduced graphene oxide materials for supercapacitor electrodes has been analyzed. A comparative study of vacuum, freeze and critical point drying was carried out for graphene oxide or hydrothermally reduced graphene oxide demonstrating that the optimization of the specific surface area and preservation of the porous network is important to maximize its properties such as supercapacitance performance. As described below, using a supercritical fluid as the drying medium, unprecedented values of specific surface area (e.g., 364 m2 g?1) and supercapacitance (e.g., 441 F g?1) for this class of materials were achieved.

Abstract: Spectrophotometry device and method for predicting a quantification of a constituent from a sample to be quantified, comprising the steps of: obtaining an electromagnetic spectrum from said biological sample; projecting said obtained spectrum into a sample point of a multiple dimension vector space associated with feature vectors, herewith a feature space, defined by a predetermined vector basis, wherein each of said dimensions is a prediction feature; selecting, if existing, a minimum of neighbouring sample points from sample points within said feature space, said sample points having been projected from previously obtained spectra each with a known constituent quantity, such that said minimum maximises the covariance of the projected spectrum of said sample to be quantified together with the projected spectra of the selected neighbouring sample points; predicting the quantification of the constituent from the sample to be quantified by correlating the known constituent quantity from the selected neighbourin

Abstract: Biophotonic device for the point-of-care, real-time, non-invasive determination of parameters with diagnostic relevance, in particular an optical system for parameter characterization of an element of body fluid or tissue comprising an optical device which comprises: a light source for emitting light onto the element; and a spectrometer for recording the spectrum of light from the element, said light from the element being of transmittance, reflectance or Raman scattering of the emitted light by said element; the optical system further comprising a data processing module configured to: convert the recorded spectrum by a conversion matrix into a standardized spectrum, wherein said conversion matrix has been obtained by calibrating the optical system spectrum response against a spectrum reference; pre-process the converted spectrum; correlate, for parameter quantification, the converted pre-processed spectrum with pre-obtained spectral bands for each parameter; said spectrum being contained within uv-vis-nir wa

Abstract: The impact of post-synthesis processing in, for example, graphene oxid or reduced graphene oxide materials for super-capacitor electrodes has been analyzed. A comparative study of vacuum, freeze and critical poin drying was carried out for graphene oxide or hydrothermally reduced graphene oxide demonstrating that the optimization of the specific surface area and preservation of the porous network is important to maximize its properties such as supercapacitance performance. As described below, using a supercritical fluid as the drying medium, unprecedented values of specific surface area (e.g., 364 m2g?1) and supercapacitance (e.g., 441 F g?1) for this class of materials were achieved.

Abstract: Biophotonic device for the point-of-care, real-time, non-invasive determination of parameters with diagnostic relevance, in particular an optical system for parameter characterization of an element of body fluid or tissue comprising an optical device which comprises: a light source for emitting light onto the element; and a spectrometer for recording the spectrum of light from the element, said light from the element being of transmittance, reflectance or Raman scattering of the emitted light by said element; the optical system further comprising a data processing module configured to: convert the recorded spectrum by a conversion matrix into a standardized spectrum, wherein said conversion matrix has been obtained by calibrating the optical system spectrum response against a spectrum reference; pre-process the converted spectrum; correlate, for parameter quantification, the converted pre-processed spectrum with pre-obtained spectral bands for each parameter; said spectrum being contained within uv-vis-nir wa

Abstract: The present disclosure relates to compositions and pharmaceutical formulations comprising at least one active pharmaceutical ingredient chosen from nitrocatechol derivatives of formula I as defined herein and salts, esters, hydrates, solvates and other derivatives thereof and methods of making the same.

Abstract: An oral suspension formulation comprising eslicarbazepine acetate and a pharmaceutically acceptable liquid vehicle.

Abstract: Biophotonic device for the point-of-care, real-time, non-invasive determination of parameters with diagnostic relevance, in particular an optical system for parameter characterization of an element of body fluid or tissue comprising an optical device which comprises: a light source for emitting light onto the element; and a spectrometer for recording the spectrum of light from the element, said light from the element being of transmittance, reflectance or Raman scattering of the emitted light by said element; the optical system further comprising a data processing module configured to: convert the recorded spectrum by a conversion matrix into a standardized spectrum, wherein said conversion matrix has been obtained by calibrating the optical system spectrum response against a spectrum reference; pre-process the converted spectrum; correlate, for parameter quantification, the converted pre-processed spectrum with pre-obtained spectral bands for each parameter; said spectrum being contained within uv-vis-nir wa

Abstract: A portable power tool actuating element for a jigsaw includes a bar-shaped handle that is intended to provide, at least indirectly, an on and off function for the power tool drive unit that drives at least one tool. A tool speed, in particular a tool stroke rate, is regulatable by the at least one portable power tool actuating element. A jigsaw includes the portable power tool actuating element. A method is provided for operating such a jigsaw.

Abstract: An oral suspension formulation comprising eslicarbazepine acetate and a pharmaceutically acceptable liquid vehicle.

Abstract: The present disclosure relates to compositions and pharmaceutical formulations comprising at least one active pharmaceutical ingredient chosen from nitrocatechol derivatives of formula I as defined herein and salts, esters, hydrates, solvates and other derivatives thereof and methods of making the same.

Abstract: With a power tool with a first operating switch for turning the power tool on and off, optimum operation of the power tool is achieved every time it is used by the fact that the power tool includes a second operating switch for turning the power tool on and off.

Abstract: The present invention discloses a DNA fragment that can direct the insertion of heterologous DNA into a specific site (tRNAAla gene) of Mycobacterium spp. genome. This DNA fragment includes the attachment site region (attP) and the integrase gene of the mycobacteriophage Ms6. Heterologous DNA linked to this DNA fragment can be carried into the mycobacterial genome through a site-specific integration mechanism. A new DNA integration process is disclosed that consists in providing the integrase gene on a suicide vector, that transiently produces the integrase required for the insertion of the gene or genes linked to the Ms6 attP region contained in a separated plasmid vector. This process allows the construction of highly stable recombinant mycobacteria which may be used as vaccines and/or therapeutic vehicles.