Abstract: The invention provides a peptide or a pharmaceutical salt thereof having a length from 14 to 50 and comprising a sequence having at least a 85% of sequence identity with respect to SEQ ID NO: 1, wherein “m”, “n”, “p”, and “q” represent integers and are selected from 0 and 1; the C-terminal end corresponds to —C(O)R4; and N-terminal end corresponds to —NHR5; the peptide optionally comprising a linker biradical “L” of formula (I) connecting an alpha carbon atom of an amino acid located at position “i” with an alpha carbon atom of an amino acid located at position “i+4” or “i+7” in the peptide sequence SEQ ID NO: 1. The present invention also provides fusion proteins and pharmaceutical compositions comprising the peptides of the invention as well as their use in therapy and, particularly, in the treatment of a disease caused by an increase or reduction in VEGF levels.

Abstract: Provided are media and methods for establishing and maintaining mammalian early embryo-like cells. The culture media can be used to culture mammalian pluripotent stem cells (PSCs), which is chemically defined and comprises basal media for culturing stem cells supplemented with a S-adenosylhomocysteine hydrolase (SAH)/Polycomb repressive complexes (PRC)/EZH2 inhibitor, a histone deacetylase (HDAC) inhibitor and a WNT/?-catenin signaling/tankyrase inhibitor. With the culture media, primate (human and non-human) PSCs can be converted to preimplantation ICM-like cells (ICLCs) or 8-cell embryo-like cells (8CLCs).

Abstract: Provided are media and methods for establishing and maintaining mammalian early embryo-like cells. The culture media can be used to culture mammalian pluripotent stem cells (PSCs), are chemically defined, and comprise basal media for culturing stem cells supplemented with a S-adenosylhomocysteine hydrolase (SAH)/Polycomb repressive complexes (PRC)/EZH2 inhibitor and a histone deacetylase (HDAC) inhibitor. With the culture media thereof, primate (human and non-human) PSCs can be converted to preimplantation ICM-like cells (ICLCs) or 8-cell embryo-like cells (8CLCs).

Abstract: Methods for generating iPSCs and differentiated cells of interest by reprogramming donor cells that have been obtained in a non-invasive manner. In particular, the donor cells are exfoliated epithelial urine cells. The differentiated cells can be obtained by differentiation of the reprogrammed iPSCs or by direct reprogramming the urine cells.

Abstract: Methods for generating iPSCs and differentiated cells of interest by reprogramming donor cells that have been obtained in a non-invasive manner. In particular, the donor cells are exfoliated epithelial urine cells. The differentiated cells can be obtained by differentiation of the reprogrammed iPSCs or by direct reprogramming the urine cells.

Abstract: A method and a plant to remove metals by biosorption from mining or industrial effluents comprising: (a) subject the effluent to at least one first stage of pre-treatment, selecting among: precipitation by pH rising, solvent extraction or solvent extraction on emulsified membranes in order to reduce its load of metals to a concentration level that allows it to be treated by the next stage of biosorption, and (b) subject the liquid that has been previously in the stage of pre-treatment to a second stage of continuous metals removal by biosorption.

Abstract: A method and a plant to remove metals by biosorption from mining or industrial effluents comprising: (a) subject the effluent to at least one first stage of pre-treatment, selecting among: precipitation by pH rising, solvent extraction or solvent extraction on emulsified membranes in order to reduce its load of metals to a concentration level that allows it to be treated by the next stage of biosorption, and (b) subject the liquid that has been previously in the stage of pre-treatment to a second stage of continuous metals removal by biosorption.

Abstract: A method and a plant to remove metals by biosorption from mining or industrial effluents comprising: (a) subject the effluent to at least one first stage of pre-treatment, selecting among: precipitation by pH rising, solvent extraction or solvent extraction on emulsified membranes in order to reduce its load of metals to a concentration level that allows it to be treated by the next stage of biosorption, and (b) subject the liquid that has been previously in the stage of pre-treatment to a second stage of continuous metals removal by biosorption.

Abstract: The invention relates to a method for producing blow-moulded sun visors comprising outer surfaces with a preferred embodiment. The outer surface of the sun visor varies in colour, surface structure and roughness. An economically-produced sun visor can thus be obtained to match the interior fittings of any motor vehicle. The structure and roughness of the outer surface of the sun visor are complementary to the inner surfaces (4) of the blow mould (1, 1?). The colour of the outer surfaces of the sun visor is also adjusted according to the coloration of the polypropylene used (2). Said coloration is obtained from organic and inorganic pigments. The invention also relates to a zip-up material cover for sun visors, which can easily be taken off and changed as required. The zip is almost completely covered by the hem and therefore cannot be seen by the passengers in the vehicle.

Abstract: A gasket for sealing between a water closet and the floor or other supporting structure. In cross section it includes a flat seat for the base of the closet, an outer flange for sealing against the outer edge of the base and an inner sealing rib formed for hinge-like deflection by and toward the base as the latter is seated. The gasket is adapted to conform to various perimetrical shapes of bases, and may include an integral gasket and sealing section for annularly and sealingly engaging the drain joint of the water closet and the surface of the floor or other supporting structure.

Abstract: A gasket for sealing between a water closet and the floor or other supporting structure. In cross section it includes a flat seat for the base of the closet, an outer flange for sealing against the outer edge of the base and an inner sealing rib formed for hinge-like deflection by and toward the base as the latter is seated. The gasket is adapted to conform to various perimetrical shapes of bases, and may include an integral gasket and sealing section for annularly and sealingly engaging the drain joint of the water closet and the surface of the floor or other supporting structure.