Patents by Inventor Miguel F. Brana

Miguel F. Brana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amonafide salts
    Patent number: 5420137
    Abstract: The monohydrochloride and the monomethanesulfonate of amonafide are described. The salts have good pharmaceutical properties besides their antitumor action.
    Type: Grant
    Filed: June 20, 1994
    Date of Patent: May 30, 1995
    Assignee: Knoll AG
    Inventors: Miguel F. Brana, Jose M. C. Berlanga, Reinhard Spengler, Christine Tetzner
  • Method for treating leukemias using N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide for treating leukemias and solid tumors
    Patent number: 5183821
    Abstract: N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide (amonafide) is an effective agent for the treatment of leukemias and solid tumors.
    Type: Grant
    Filed: July 8, 1991
    Date of Patent: February 2, 1993
    Assignee: Laboratories Knoll, S.A.
    Inventors: Miguel F. Brana, Antonio M. Sanz, Rafael P. Alvarez-Ossorio, Cristobal M. Roldan, Cristina R. F. De Gamboa, Jesus G. Garcia, Jose M. C. Berlanga
  • Bisnaphthalimides
    Patent number: 4874863
    Abstract: Bisnaphthalimides of the formula I ##STR1## where X.sup.1 to X.sup.4 and R have the meanings stated in the description, and their preparation are described. The compounds are cytotoxic towards human cells in vitro.
    Type: Grant
    Filed: March 1, 1988
    Date of Patent: October 17, 1989
    Assignee: Knoll AG
    Inventors: Miguel F. Brana, Jose M. C. Berlanga, Gerhard Keilhauer, Erich Schlick
  • 1,2-Diacylamino-1,2-di(4-pyridyl)ethanes and process for producing thereof
    Patent number: 4288597
    Abstract: 1,2-diacylamino-1,2-di(4-pyridil)ethanes of general formula: ##STR1## where R is a saturated or unsaturated alkyl group, a homocyclic or heterocyclic aromatic ring, with or without substituents, or a saturated or unsaturated cycloalkyl. Said compounds are useful as analgesic. A process for preparing such products is also described.
    Type: Grant
    Filed: March 10, 1980
    Date of Patent: September 8, 1981
    Assignee: Laboratorios Made, S.A.
    Inventors: Miguel F. Brana, Maria L. Lopez Rodriguez, Jose M. Castellano Berlanga, Jose L. Soto Camara, Cristobal Martinez Roldan
  • N(Aminoalkyl)-naphthalimides and their derivatives
    Patent number: 4204063
    Abstract: N-substituted-3-substituted naphthalimides are prepared by reacting 3-substituted naphthalic acid with a compound having a primary amino group. The naphthalimides possess cytotoxic properties.
    Type: Grant
    Filed: June 2, 1978
    Date of Patent: May 20, 1980
    Assignee: Laboratorios Made, S.A.
    Inventors: Miguel F. Brana, Antonio M. Sanz, Rafael P. Alvarez-Ossorio, Cristobal M. Roldan, Cristina R. Fernandez de Gamboa
  • N-Aminoethyl-substituted-3-nitronaphthalimides
    Patent number: 4146720
    Abstract: Compounds having the formula ##STR1## wherein Y is 2-dimethylaminoethyl, 2-diethylaminoethyl, 2-(N-pyrrolidino)ethyl or 2-(N-piperidino)ethyl. The compounds are prepared by reacting 3-nitronaphthalic acid, or corresponding anhydride, with the corresponding primary amine. The compounds possess cytostatic and raticide properties.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: March 27, 1979
    Assignee: Laboratorios Made, S.A.
    Inventors: Cristobal M. Roldan, Miguel F. Brana, Jose M. C. Berlanga