Patents by Inventor Miguel Garcia-Guzman Blanco

Miguel Garcia-Guzman Blanco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of Muscarinic Receptors
    Publication number: 20130281476
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: June 17, 2013
    Publication date: October 24, 2013
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Spiroindoline modulators of muscarinic receptors
    Patent number: 8497295
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: July 30, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Modulators of muscarinic receptors
    Patent number: 8367691
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: February 5, 2013
    Assignee: Vertex Pharmaceutical Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Spiroindoline Modulators of Muscarinic Receptors
    Publication number: 20120283243
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: July 11, 2012
    Publication date: November 8, 2012
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Modulators of muscarinic receptors
    Patent number: 8263605
    Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: September 11, 2012
    Assignee: Vertex Pharmaceutical Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Spiroindoline modulators of muscarinic receptors
    Patent number: 8258148
    Abstract: The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: September 4, 2012
    Assignee: Vertex Pharmaceutical Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Spiroindoline modulators of muscarinic receptors
    Patent number: 7879834
    Abstract: The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: August 19, 2005
    Date of Patent: February 1, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis R. Hurley, Ioana Drutu, Gabriel Raffai, Daniele J. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Bicyclic substituted phenyl piperidine modulators of muscarinic receptors
    Patent number: 7880007
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: February 1, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dennis J. Hurley, Daniele M. Bergeron, Ioana Drutu, Miguel Garcia-Guzman Blanco, Lewis R. Makings, Akiko Nakatani, Gabriel Raffai, Alina Silina
  • Modulators of muscarinic receptors
    Patent number: 7863449
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: January 4, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Ioana Drutu, Dennis J. Hurley, Upul K. Bandarage, Daniele M. Bergeron, Paul S. Charifson, Robert J. Davies, Miguel Garcia-Guzman Blanco, Lewis R. Makings, Akiko Nakatani, Gabriel Raffai
  • Spiro compounds as modulators of muscarinic receptors
    Patent number: 7858635
    Abstract: The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: December 28, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • MODULATORS OF MUSCARINIC RECEPTORS
    Publication number: 20100311746
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: June 4, 2010
    Publication date: December 9, 2010
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Spiroindoline Modulators of Muscarinic Receptors
    Publication number: 20100311720
    Abstract: The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: May 24, 2010
    Publication date: December 9, 2010
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Dihydrospiroindene modulators of muscarinic receptors
    Patent number: 7786141
    Abstract: The present invention relates to dihydrospiroindene modulators of muscarinic receptors. The present invention also provides compositions comprising such dihydrospiroindene modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: August 31, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Muscarinic modulators
    Patent number: 7786308
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: August 31, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Ioana Drutu, Miguel Garcia-Guzman Blanco, Lewis R. Makings, Gabriel Raffai, Valentin Boris Zunic
  • Phenyl-piperazine derivatives as modulators of muscarinic receptors
    Publication number: 20090239873
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: December 31, 2008
    Publication date: September 24, 2009
    Inventors: Miguel Garcia-Guzman Blanco, Daniele Bergeron, Peter D. J. Grootenhuis, Dennis Hurley, Akiko Nakatani, Lewis R. Makings, Daniel DiSepio, Gabriel Raffai
  • Modulators of Muscarinic Receptors
    Publication number: 20090227614
    Abstract: The present invention relates to modulators of muscarnic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: February 22, 2007
    Publication date: September 10, 2009
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Phenyl-piperazine derivatives as modulators of muscarinic receptors
    Patent number: 7563795
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: July 21, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Miguel Garcia-Guzman Blanco, Daniele Bergeron, Peter D. J. Grootenhuis, Dennis Hurley, Akiko Nakatani, Lewis R. Makings, Daniel DiSepio, Gabriel Raffai
  • Modulators of muscarinic receptors
    Publication number: 20090042928
    Abstract: The modulator compounds described herein modulate muscarinic receptors and are useful for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: June 26, 2008
    Publication date: February 12, 2009
    Inventors: Peter D. J. Grootenhuis, Miguel Garcia-Guzman Blanco, Lewis R. Makings, Philip Martin Londo
  • Modulators of muscarinic receptors
    Patent number: 7446112
    Abstract: The modulator compounds described herein modulate muscarinic receptors and are useful for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: November 4, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Peter D. J. Grootenhuis, Miguel Garcia-Guzman Blanco, Lewis R. Makings, Philip Martin Londo
  • Modulators of muscarinic receptors
    Publication number: 20050171141
    Abstract: The modulator compounds described herein modulate muscarinic receptors and are useful for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: December 7, 2004
    Publication date: August 4, 2005
    Inventors: Peter Grootenhuis, Miguel Garcia-Guzman Blanco, Lewis Makings, Philip Martin Londo