Abstract: In accordance with an embodiment, described herein is a system and method for streaming music on mobile devices, including those which may have limited support for streaming. In response to receiving a request for portions of media content to be retrieved from a media server and played at a media device, selected parts of a media content file (e.g., an MP3 file) can be downloaded from a media server, and prepended, appended, or otherwise adjusted into a complete (albeit relatively shorter) media content, which is decoded and sent, for example to an audio speaker at the media device. The approach provides flexibility in providing access to a media streaming service from non-native mobile device applications, for example by enabling a media application to load and play encrypted MP3 file content in environments such as mobile browsers that require low memory consumption, or do not support Media Source Extensions.

Abstract: A method for enhancing at least one of craving-reduction, mood improvement, avoidance of depression, prevention of weight gain post weight-loss from dieting, reduction of negative side effects produced by anti-appetite drugs and smoke-cessation and promotion of healthy ageing in a person in need thereof, comprising administering a composition to said person, said composition comprising: a) an effective amount of an extract of Cyperus esculentus peel, Cyperus esculentus rhizomes, or a combination thereof; b) an effective amount of mangiferin, norathyriol, or an extract comprising mangiferin or norathyriol; or c) a synergistic combination of (a) and (b). The composition may comprise a third active ingredient in combination with the Cyperus esculentus extract and mangiferin or norathyriol.

Abstract: The present invention provides engineered DNase proteins (including DNase1-like 3 and DNase1) that are useful for treating conditions characterized by neutrophil extracellular trap (NET) accumulation and/or release. In some aspects, the invention provides compositions and methods for preventing or treating vascular occlusion involving NETs. As demonstrated herein, NETs participate in a non-canonical mechanism for vascular occlusion, which is not dependent on fibrin or platelets.

Abstract: The present invention provides engineered DNase proteins (including DNase1-like 3 and DNase1) that are useful for treating conditions characterized by neutrophil extracellular trap (NET) accumulation and/or release. In some aspects, the invention provides compositions and methods for preventing or treating vascular occlusion involving NETs. As demonstrated herein, NETs participate in a non-canonical mechanism for vascular occlusion, which is not dependent on fibrin or platelets.

Abstract: The present invention provides engineered DNase proteins (including DNase1-like 3 and DNase1) that are useful for treating conditions characterized by neutrophil extracellular trap (NET) accumulation and/or release. In some aspects, the invention provides compositions and methods for preventing or treating vascular occlusion involving NETs. As demonstrated herein, NETs participate in a non-canonical mechanism for vascular occlusion, which is not dependent on fibrin or platelets.

Abstract: The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: A stovetop oven having an audio system comprising of a stove assembly and an audio assembly is disclosed herein. The stove assembly includes a stovetop and an oven that is configured to aid a user in cooking food. The audio assembly comprises a display unit having a processor, speakers, and a radio. The display unit displays the current media being played by a user utilizing the stove. Additionally, a user may navigate and control the audio media being played using buttons configure to the display unit. The processor allows the unit to play audio media through various forms such as WIFI, Bluetooth, and satellite radio. The radio of the audio assembly receives radio signals allows the user to tune into various radio channels for their enjoyment. The stove top oven having an audio system creates an entertaining environment for a user in the kitchen.

Abstract: The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.

Abstract: The present invention provides engineered DNase proteins (including DNase1-like 3 and DNase1) that are useful for treating conditions characterized by neutrophil extracellular trap (NET) accumulation and/or release. In some aspects, the invention provides compositions and methods for preventing or treating vascular occlusion involving NETs. As demonstrated herein, NETs participate in a non-canonical mechanism for vascular occlusion, which is not dependent on fibrin or platelets.

Abstract: Methods and apparatuses are provided for self-trimming of a semiconductor device. An example self-trimming circuit includes a control circuit configured to, during a self-trimming operation, decode a test command signal to set a target voltage and set a voltage trim code to an initial value, and to adjust a value of the voltage trim code based on a stop signal. The example self-trimming circuit further includes a reference voltage regulator configured to receive the voltage trim code and to convert a band-gap reference voltage to an output voltage based on the voltage trim code, and a comparator configured to compare the target voltage with the output voltage and to provide the stop signal having a value based on the comparison.

Abstract: A platform technology has been designed to provide a means for controlled delivery of single or multiple doses of therapeutic, prophylactic, diagnostic or identifying agents to livestock. The delivery system is based on a livestock ear tag that releases therapeutic and/or prophylactic agent when applied to the ear or other desired anatomical target of the animal. The agent to be delivered is encapsulated in or on microneedles and or microparticles and or nanoparticles or combination thereof on a surface thereon of the male or female part of the tag, which is pressed into the skin so that the microneedles penetrate into the epidermis and dermis layers of the skin. The agent is then released into the animal from the microneedles and or microparticles and or nanoparticles or combination thereof at the site of contact into the epidermis and dermis layers of the skin.

Abstract: Methods and apparatuses are provided for self-trimming of a semiconductor device. An example self-trimming circuit includes a control circuit configured to, during a self-trimming operation, decode a test command signal to set a target voltage and set a voltage trim code to an initial value, and to adjust a value of the voltage trim code based on a stop signal. The example self-trimming circuit further includes a reference voltage regulator configured to receive the voltage trim code and to convert a band-gap reference voltage to an output voltage based on the voltage trim code, and a comparator configured to compare the target voltage with the output voltage and to provide the stop signal having a value based on the comparison.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: In accordance with an embodiment, described herein is a system and method for streaming music on mobile devices, including those which may have limited support for streaming. In response to receiving a request for portions of media content to be retrieved from a media server and played at a media device, selected parts of a media content file (e.g., an MP3 file) can be downloaded from a media server, and prepended, appended, or otherwise adjusted into a complete (albeit relatively shorter) media content, which is decoded and sent, for example to an audio speaker at the media device. The approach provides flexibility in providing access to a media streaming service from non-native mobile device applications, for example by enabling a media application to load and play encrypted MP3 file content in environments such as mobile browsers that require low memory consumption, or do not support Media Source Extensions.

Abstract: Methods and apparatuses are provided for self-trimming of a semiconductor device. An example apparatus includes a semiconductor device including a self-trimming circuit configured to receive a reference voltage and a test command signal. The self-trimming circuit is configured to convert the reference voltage to a target voltage based on the test command signal and further configured to adjust a voltage trim code until an internal voltage matches the target voltage to determine a trim level associated with the internal voltage.

Abstract: A liveness detection system comprises a controller, a video input, a feature recognition module, and a liveness detection module. The controller is configured to control an output device to provide randomized outputs to an entity over an interval of time. The video input is configured to receive a moving image of the entity captured by a camera over the interval of time. The feature recognition module is configured to process the moving image to detect at least one human feature of the entity. The liveness detection module is configured to compare with the randomized outputs a behaviour exhibited by the detected human feature over the interval of time to determine whether the behaviour is an expected reaction to the randomized outputs, thereby determining whether the entity is a living being.

Abstract: The present invention provides engineered DNase proteins (including DNase1-like 3 and DNase1) that are useful for treating conditions characterized by neutrophil extracellular trap (NET) accumulation and/or release. In some aspects, the invention provides compositions and methods for preventing or treating vascular occlusion involving NETs. As demonstrated herein, NETs participate in a non-canonical mechanism for vascular occlusion, which is not dependent on fibrin or platelets.

Abstract: A method for enhancing at least one of alertness, attention, concentration and memory in a person in need thereof, comprising administering a composition to said person, said composition comprising: a) an effective amount of an extract of Cyperus esculentus peel, Cyperus esculentus rhizomes, or a combination thereof; b) an effective amount of mangiferin, norathyriol, or an extract comprising mangiferin or norathyriol; or c) a synergistic combination of (a) and (b).

Abstract: Systems and methods for calibrating and controlling leaves of a multi-leaf collimator are disclosed. According to an exemplary method, a controller may receive images of collimator leaves and may determine a minor offset between an imaging marker and the tip of the respective leaf. In addition, the controller may quantify a barrel distortion effect associated with a leaf-imaging camera. The controller may correct leaf position data using the minor offsets and barrel distortion quantification, and may use the corrected leaf positions to accurately place the leaves during radiotherapy. Advantageously, a desired beam shaping window may be formed with the leaves, ensuring that healthy tissue is minimally irradiated while also ensuring that the target tissue receives the correct radiation dose. Embodiments of the present disclosure provide collimator calibration techniques which may be faster than prior calibration techniques, allowing shortened calibration times and faster radiotherapy sessions.