Abstract: A nacelle includes in turn a nacelle frame, and a yaw bearing having likewise/in turn at least a geared ring for providing a rotatable connection between the nacelle and the tower around a yaw axis. A method includes the steps of: a) disengaging the rotatable connection between the nacelle and the tower; b) lifting the nacelle from the tower by using lifting means, allowing the rotation of the geared ring; and c) rotating the geared ring around the yaw axis until the geared ring reaches a predetermined position with respect to the component to which the geared ring is connectable, either to the nacelle or the tower.

Abstract: The invention provides a peptide or a pharmaceutical salt thereof having a length from 14 to 50 and comprising a sequence having at least a 85% of sequence identity with respect to SEQ ID NO: 1, wherein “m”, “n”, “p”, and “q” represent integers and are selected from 0 and 1; the C-terminal end corresponds to —C(O)R4; and N-terminal end corresponds to —NHR5; the peptide optionally comprising a linker biradical “L” of formula (I) connecting an alpha carbon atom of an amino acid located at position “i” with an alpha carbon atom of an amino acid located at position “i+4” or “i+7” in the peptide sequence SEQ ID NO: 1. The present invention also provides fusion proteins and pharmaceutical compositions comprising the peptides of the invention as well as their use in therapy and, particularly, in the treatment of a disease caused by an increase or reduction in VEGF levels.

Abstract: The present invention relates to a control method for a high-speed fluid injection system and a system configured for implementing the control method. Similarly, the invention has a monitoring system for the system configured for implementing the control method. In particular, the present invention allows automatically, precisely, and continuously controlling the amount of fluid injected or applied to a plurality of parts.

Abstract: The present invention refers to an In vitro method for screening for subjects at risk of developing thoracic aortic aneurysm (TAA) or a disease causing TAA comprising: (a) measuring the expression pattern or level of at least A Disintegrin And Metalloproteinase with Thrombospondin Motifs 1 (ADAMTS1) obtained from an isolated biological sample of the subjects to be screened; and (b) comparing said expression pattern or level of at least ADAMTS1 of the subjects to be screened with an already established expression pattern or level, wherein reduced expression of at least ADAMTS1 is indicative of a thoracic aortic aneurysm (TAA).

Abstract: The present invention refers to an In vitro method for screening for subjects at risk of developing thoracic aortic aneurysm (TAA) or a disease causing TAA comprising: (a) measuring the expression pattern or level of at least A Disintegrin And Metalloproteinase with Thrombospondin Motifs 1 (ADAMTS1) obtained from an isolated biological sample of the subjects to be screened; and (b) comparing said expression pattern or level of at least ADAMTS1 of the subjects to be screened with an already established expression pattern or level, wherein reduced expression of at least ADAMTS1 is indicative of a thoracic aortic aneurysm (TAA).

Abstract: The present invention refers to an In vitro method for screening for subjects at risk of developing thoracic aortic aneurysm (TAA) or a disease causing TAA comprising: (a) measuring the expression pattern or level of at least A Disintegrin And Metalloproteinase with Thrombospondin Motifs 1 (ADAMTS1) obtained from an isolated biological sample of the subjects to be screened; and (b) comparing said expression pattern or level of at least ADAMTS1 of the subjects to be screened with an already established expression pattern or level, wherein reduced expression of at least ADAMTS1 is indicative of a thoracic aortic aneurysm (TAA).

Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample. The device comprises a lateral flow membrane (46) comprising a plurality of test regions (41A, 41B) and formed from a light transmissive material, a plurality (44A, 44B) of planar organic light emitting diode (OLED) emitters comprising an emission layer of an organic electroluminescent material, and a plurality (49A, 49B) of planar organic photodetectors (OPDs) comprising an absorption layer of an organic photovoltaic material. Each test region comprises an immobilised component for retaining analyte tagging particles. Each test region is aligned with the emission layer of one emitter and the absorption layer of one photodetector. The aligned emitter, photodetector, and test region form a group such that the emitter is capable of illuminating the test region and the photodetector is capable of detecting light from the test region.

Abstract: A computer system and method is provided to filter clearance sensor data output by a sensor system during a load/offload procedure of a first object relative to a second object. A processing device of the computer system is configured to access hard threshold data, unique threshold data, and sensor data output by the sensor system sensing aspects of the load/offload procedure. The processing device is further configured to determine whether the sensor data exceeds the unique threshold, determine whether the sensor data that is determined to exceed the unique threshold is voidable data related to a noncritical event, and generate filtered sensor data that includes modifications to the voidable data.

Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample comprises a planar emitter (2), a planar detector (3), a lateral flow membrane (4) interposed between the emitter (2) and the detector (3), a conjugate pad (5) in fluid communication with a proximal end of the lateral flow membrane (4), the conjugate pad (5) comprising optically detectable tagging particles bound to a first assay component, a sample pad (6) in fluid communication with the conjugate pad (5) and arranged to receive the liquid sample, and a wicking pad (7) in fluid communication with a distal end of the lateral flow membrane (4). The lateral flow membrane (4) is formed from a light transmissive material and is capable of transporting fluid from the conjugate pad (5) to the wicking pad (7) by capillary action.

Abstract: An improved optical detection unit for an assay device, such as a lateral flow device, for the quantitative determination of the concentration of an analyte in a liquid sample, and an assay device comprising the same. The detection unit comprises an organic light emitting diode (OLED) emitter that has an emission spectrum E within the wavelength range from ?1 to ?2, and an organic photodiode detector (OPD) that has a light detection spectrum S within the wavelength range from ?1 to ?2. The detection unit has a test region that comprises a light absorbing component that has an absorbance spectrum A within the wavelength range from ?1 to ?2. The test region is positioned adjacent to the emitter and the detector to form an optical pathway from the light emitting diode to the photodiode through at least a portion of the test region. Formula M defines a relationship between E, S and A, and M is less than about 0.4.

Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample comprises a planar emitter 2, a planar detector 3, a lateral flow membrane 4 interposed between the emitter 2 and the detector 3, a conjugate pad 5 in fluid communication with a proximal end of the lateral flow membrane 4, the conjugate pad 5 comprising optically detectable tagging particles bound to a first assay component, a sample pad 6 in fluid communication with the conjugate pad 5 and arranged to receive the liquid sample, and a wicking pad 7 in fluid communication with a distal end of the lateral flow membrane 4. The lateral flow membrane 4 is formed from a light transmissive material and is capable of transporting fluid from the conjugate pad 5 to the wicking pad 7 by capillary action.

Abstract: The present invention relates to a procedure for remineralization of fluids with control over the final turbidity. The said procedure comprises the stages of dosage of the reagents, remineralization and filtration. More specifically, the invention relates to the treatment of water for human consumption, for industrial processes, agricultural use and other applications which require adjustment of parameters such as hardness, alkalinity, pH, Langelier saturation index (LSI), etc.

Abstract: The invention consists of a nasal aspirator like a syringe, configured from a hollow tubular body with a nozzle that may or may not be interchangeable, that is provided with a filter and incorporates in the inner part a plunger formed by a front top, a central rod and a rear push element, having said push element holding means sized and configured for the user's thumb, whose holding means consist of a ring opened and formed by respective curved appendages, arising perpendicularly from the circular base defining said push element and being oriented such that they face one another.