Abstract: Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.

Abstract: Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.

Abstract: Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.

Abstract: An apparatus for accurately positioning an object such as a radiation probe within a defined three dimensional space has a pair of support bars extending along each of three perpendicular axes defining said space with bearing block supports slidably mounted along each set of support rods. A cable drive for each direction of movement is provided to move these bearing blocks including a drive motor, a drum assembly including a capstan and cable guide, a drive cable, and a plurality of pulleys spaced along the system to achieve a balanced movement of the system in the associated direction. The cable is aligned so that each section of its run is either perpendicular or parallel to its other sections and is arranged with the capstan and cable guide so that there is an increase of tension as the cable is reeled in and a decrease of tension as the cable is payed out to reduce the stretching of the cable as the apparatus is operated.