Patents by Inventor Miguel S. Barbosa

Miguel S. Barbosa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Markers for evaluating estrogenic activity
    Publication number: 20030054332
    Abstract: Methods are provided for evaluating estrogenic and antiestrogenic effects of candidate therapeutic agents. Such methods are generally based on assays to detect modulation of estrogen-regulated marker expression in one or more specific cell types. Agents identified using such methods may be used, for example, in the prevention and treatmnt of diseases such as osteoporosis, cardiovascular disease and cancer.
    Type: Application
    Filed: May 10, 2001
    Publication date: March 20, 2003
    Inventors: Miguel S. Barbosa, Helen A. Brady, Kyle W.H. Chan, Jose R. Pardinas
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUMAN CYTOMEGALOVIRUS INFECTION
    Publication number: 20020010143
    Abstract: Compositions and methods are provided for identifying proteins and other agents that modulate transactivation of HCMV early genes. In particular, agents that inhibit the cell-type specific transactivation of HCMV DNA polymerase are provided. Such agents may be used, for example, in the treatment of patients infected with HCMV.
    Type: Application
    Filed: May 6, 1999
    Publication date: January 24, 2002
    Inventors: MIGUEL S. BARBOSA, JUN WU
  • Method for identifying agents that modulate transcription of human cytomegalovirus polymerase
    Patent number: 5981188
    Abstract: Compositions and methods are provided for identifying proteins and other agents that modulate transactivation of HCMV early genes. In particular, agents that inhibit the cell-type specific transactivation of HCMV DNA polymerase are provided. Such agents may be used, for example, in the treatment of patients infected with HCMV.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: November 9, 1999
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Miguel S. Barbosa, Jun Wu
  • Reporter cell line system for detecting cytomegalovirus and identifying modulators of viral gene expression
    Patent number: 5945276
    Abstract: Cell lines and methods for detecting cytomegalovirus infection and identifying modulators of cytomegalovirus gene expression are disclosed. The cell lines carry an integrated plasmid that contains a reporter gene under the control of a cytomegalovirus promoter. Such cell lines may be used, for example, for specifically identifying HCMV infection in a biological sample.
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: August 31, 1999
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Jun Wu, Miguel S. Barbosa, Carla M. Suto
  • Method for identifying agents that modulate transcription of human cytomegalovirus polymerase
    Patent number: 5910411
    Abstract: Compositions and methods are provided for identifying proteins and other agents that modulate transactivation of HCMV early genes. In particular, agents that inhibit the cell-type specific transactivation of HCMV DNA polymerase are provided. Such agents may be used, for example, in the treatment of patients infected with HCMV.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: June 8, 1999
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Miguel S. Barbosa, Jun Wu