Patents by Inventor Miguel Varela

Miguel Varela has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATE AND USES THEREOF
    Publication number: 20220275372
    Abstract: The present invention relates to conjugates formed from a cell-penetrating peptide carrier linked to a therapeutic molecule, wherein the peptide carrier is defined by specific domains and the therapeutic molecule is a nucleic acid formed of trinucleotide repeats. The present invention further relates to the use of such a conjugate in methods of treatment or as a medicament, especially in the treatment of trinucleotide repeat disorders such as myotonic dystrophy (DM1).
    Type: Application
    Filed: August 7, 2020
    Publication date: September 1, 2022
    Applicants: OXFORD UNIVERSITY INNOVATION LIMITED, UNITED KINGDOM RESEARCH AND INNOVATION, ASSOCIATION INSTITUT DE MYOLOGIE, INSERM (INSTITUT NATONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), SORBONNE UNIVERSITE
    Inventors: Matthew Wood, Miguel Varela, Ashling Holland, Richard Raz, Denis Furling, Arnaud Klein, Michael Gait
  • LINKERS
    Publication number: 20220125934
    Abstract: The present invention relates to linkers for connecting a carrier molecule to a therapeutic molecule to form a conjugate, in particular linkers formed of amino acids such as glutamic acid, succinic acid, and gamma-aminobutyric acid. The present invention further relates to a conjugate comprising a linker of the invention, and the use of said conjugate in the treatment of various diseases.
    Type: Application
    Filed: December 6, 2019
    Publication date: April 28, 2022
    Inventors: Richard Raz, Matthew Wood, Caroline Godfrey, Graham McClorey, Subhashis Banerjee, Michael Gait, Miguel Varela, Ashling Holland
  • CELL-PENETRATING PEPTIDES
    Publication number: 20210299263
    Abstract: The present invention relates to peptides, in particular cell-penetrating peptides, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.
    Type: Application
    Filed: August 9, 2019
    Publication date: September 30, 2021
    Inventors: Matthew Wood, Raquel Manzano, Caroline Godfrey, Graham McClorey, Richard Raz, Michael Gait, Andrey Arzumanov, Liz O'Donovan, Gareth Hazell, Ashling Holland, Miguel Varela