Abstract: A method for administering human umbilical cord blood mesenchymal stem cell transfusion immunotherapy to a patient for treatment of coronavirus infection. The method includes harvesting umbilical cord mesenchymal stem cells, culturing the stem cells, collecting and purifying the cultured stem cells, placing the purified stem cells into a transfusion bag, and intravenously transfusing the stem cells from the transfusion bag into the patient having the infection.

Abstract: A method for attaching a laminar plate to a vertebra during spinal surgery, especially minimally invasive spinal surgery, to reconstruct the lamina of the vertebra after it has been removed during the surgery and prevent bone re-growth material from entering the spinal canal. The laminar plate can be coupled to, or proximate to, and between a facet and the spinous process by screwing the plate to the bone.

Abstract: A spinal fusion implant that is inserted into a cleared disc space during a spinal fusion surgical procedure using an insertion tool, where the insertion tool also provides delivery of bone graft material once the implant is in the disc space. The implant includes a perimeter portion having a front wall, a back wall and opposing side walls defining an enclosure, where the perimeter portion is open in an up and down direction, and where the front wall includes an opening extending therethrough to the enclosure and being configured to accept the bone graft material to fill the enclosure.

Abstract: A pedicle screw distraction device that includes first and second pedicle screws each including a screw body portion and a ball head. The device also includes first and second screw head portions each including an internal threaded bore where the first screw is inserted in the first screw head portion and the second screw is inserted in the second screw head portion. The device also includes a connector link coupled to the first and second screw head portions where the connector link includes an outer perimeter portion having a slot therein. A spring member is positioned within the connector link between and in contact with the first and second screw head portions. A locking member including a plate and a separating portion is positioned between the screw head portions and an inside wall of the connector link where the separating portion is positioned between the screw head portions.

Abstract: A method for placement of a pedicle screw and rod system that has particular application for spinal fusion surgery. The system includes pedicle screws having ball-shaped heads that are threaded through pedicles of adjacent vertebra into the vertebral body. The system also includes two cannulated posts having a head portion with a planar portion and an opening for accepting the head of the pedicle screw in a secure and multi-axial engagement. The system further includes a tube portion that is coupled to the head portion and extends above the patient's skin. The system also includes a lordotic slotted rod that is slid down the tube portions to be positioned on top of the head portions of the posts so that the planar portions are locked within the slot. Bolts are then slid down the tube portions and are threaded to a threaded portion on the planar portion.

Abstract: A laminar plate that reconstructs or supports the lamina of a vertebra after lamina bone has been removed during spinal surgery and prevents bone growth material from entering the spinal canal. The laminar plate spans a gap from the removed lamina bone and is coupled to, or proximate to, and between a facet and the spinous process by screwing the plate to the bone.

Abstract: A bone graft system for providing bone graft material to a site of interest includes a multiple unit bone graft material loading device and a conduit. The multiple unit bone graft material loading device may be configured to accept a plurality of pre-formed bone graft material units and includes a plurality chambers configured to accept a pre-formed bone graft unit. The conduit may include a first opening and second opening. The first opening may be operably connected with the multiple unit bone graft material loading device to accept bone graft material from the multiple unit bone graft material loading device. The second opening may be configured to deliver bone graft material to a site of interest.

Abstract: An interspinous process spacer device that is operable to be positioned between the spinous process of adjacent vertebra. The spacer device includes a body portion having a central bore extending therethrough, where the body portion includes a cylindrical center portion, a tapered front-end portion and a threaded portion, and where the center portion includes circumferentially disposed channels for delivering bone graft material. The spacer device also includes a spacer ring having an outer rim with a larger diameter than the center portion and a threaded opening that allows the spacer ring to be threaded onto the threaded portion. The spacer device further includes a securing member positioned against the spacer ring and including a threaded opening that allows the member to be threaded onto the threaded portion opposite to the center portion so that the spinous process can be locked between the front-end portion and the spacer ring.

Abstract: A minimally invasive surgical access device that allows access to a pathology being treated while significantly reducing the risk of damaging anatomical structures proximate the pathology. The access device includes a base portion having a central bore extending therethrough, and retractor blades pivotably mounted to the base portion. An insertion handle is coupled to the base portion to thread the retractor blades into the patient. The insertion handle is removed from the base portion, and a core hollow screw is threaded into the base portion to separate the retractor blades to gain access to the pathology through the hollow screw.

Abstract: A pedicle screw and rod assembly that has particular application for minimally invasive percutaneous pedicle screw instrumentation. The assembly includes pedicle screws having ball-shaped heads that are threaded through pedicles of adjacent vertebra into the vertebral body. The assembly also includes two cannulated posts that extend above a cannulated pedicle screw to allow placement over a K-wire. A head portion accepts the head of the pedicle screw in a secure and multi-axial engagement. The assembly further includes a tube portion that is coupled to the head portion and extends above the patient's skin. The assembly also includes a lordotic slotted rod that is slid down the tube portions to be positioned on top of the head portions of the posts so that the portions are locked within the slot. Bolts are then slid down the tube portions and are threaded to a threaded portion on the portion.

Abstract: A spacer for implantation between adjacent vertebrae is provided. The spacer includes a distal end and a proximal end. The spacer also includes top and bottom surfaces spaced by sides. The top and bottom surface define a height, and the sides define a width. Each of the sides of the spacer may include a depressed region sunk into the side including a sloped surface at least toward the proximal end of the spacer. The distance between the sloped surfaces of the sides may decrease proximally to form a web having a leading edge proximate to the proximal end of the spacer. The web may be sized and configured to aid distribution of bone graft material to either side of the spacer, wherein bone graft material is supplied to a site of interest is distributed to at least one side of the spacer.

Abstract: A regeneration device and method for sealing annular tears between the nucleus pulposus and the annulus fibrosus of an intervertebral disc. The regeneration device includes a trocar having a sharp tip at a distal end, an inner cavity, and a handle portion attached to a proximal end of the trocar. The device further includes a plunger coupled to a catheter that extends through the inner cavity. The regeneration method includes inserting the trocar into an intervertebral disc via Kambin's triangle, and once the trocar reaches the nucleus pulposus, the catheter is extended alongside the annulus fibrosus wall to surround the nucleus pulposus. A syringe is mounted to the plunger and injects a biochemical, biological and/or synthetic material through multiple ports in the catheter to form a collagen barrier that prevents the nucleus pulposus from protruding through the annulus fibrosus.

Abstract: A method for administering a barrier cell treatment for malignant or benign tumor cells. The method includes preparing a material including chondrocytes and placing the material around the tumor cells. Preparing the material can include harvesting and culturing chondrocytes from the patient.

Abstract: A needle delivery device that has particular application for providing needles for minimally invasive spinal surgical procedures. The device includes an elongated pincher having opposing rails that is slidable within a channel defined in an extended base portion. Widened end portions of the rails hold the needle and push it out of an end of the device where it is released. The pincher is then retracted to a location where the end portions can pick up a next needle to be delivered.

Abstract: A disc distraction device comprising a first pedicle screw having a mounting end and a head end, a second pedicle screw having a mounting end and a head end, a rigid interconnection member coupled proximate the head end of both the first and second pedicle screws, and a spring member coupled to the first and second pedicle screws closer to the mounting ends of the pedicle screws than the rigid interconnection member.

Abstract: A disc distraction device comprising a first pedicle screw having a mounting end and a head end, a second pedicle screw having a mounting end and a head end, a rigid interconnection member coupled proximate the head end of both the first and second pedicle screws, and a spring member coupled to the first and second pedicle screws closer to the mounting ends of the pedicle screws than the rigid interconnection member.

Abstract: A robotic surgical device positioning system that allows a surgeon to accurately and remotely position a surgical instrument relative to a patient and to provide fluoroscopic images of the instrument without exposing the surgeon to radiation. The system includes a vertical post that is slidebly coupled to an operating table, a clamp mounted to the vertical post and spaced from the table, and a translational arm mounted to the clamp. The system further includes an instrument positioning assembly mounted to the translational arm opposite to the clamp that includes a plurality of sliding elements that are slidebly mounted to the assembly to provide rotational, anterior-posterior and medial-lateral positioning of the surgical instrument. A control unit is mechanically coupled to the instrument positioning assembly at a remote location by flexible cables for controlling the position of the sliding elements.

Abstract: A minimally invasive interbody device assembly that includes an interbody device that restores the disc space height between two vertebrae and an instrument detachably coupled to the interbody device for positioning the device in the disc space and delivering bone material to the disc space that is distributed on both sides of the interbody device. The device is inserted into the disc space using the instrument in a direction so that the wide dimension of the device is substantially parallel to the body of the vertebrae. The device is then rotated by the instrument so that the wide dimension of the device becomes perpendicular to the vertebral body so as to cause the disc space height to be restored. Bone graft material is then forced down the instrument so that the bone graft material is distributed on both sides of the device. The instrument is then detached from the device.

Abstract: An up-cutting knife that has particular application for minimally invasive spinal surgical procedures. The knife includes an elongated tube that is operable to be inserted through a tubular retractor used in minimally invasive surgical procedures. One end of the elongated tube includes a curved head portion having a cutting blade formed on a top surface thereof and a suction port, and an opposite end of the tube is coupled to a handle having a chamber. A suction device can be coupled to an outlet port in the handle that causes blood and other surgical material to be drawn through the tube and out of the handle.

Abstract: A spacer for implantation between adjacent vertebrae is provided. The spacer includes a distal end and a proximal end. The spacer also includes top and bottom surfaces spaced by sides. The top and bottom surface define a height, and the sides define a width. Each of the sides of the spacer may include a depressed region sunk into the side including a sloped surface at least toward the proximal end of the spacer. The distance between the sloped surfaces of the sides may decrease proximally to form a web having a leading edge proximate to the proximal end of the spacer. The web may be sized and configured to aid distribution of bone graft material to either side of the spacer, wherein bone graft material is supplied to a site of interest is distributed to at least one side of the spacer.