Patents by Inventor Mihael Polymeropoulos

Mihael Polymeropoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liquid Tasimelteon Formulations and Methods of Use Thereof
    Publication number: 20230372285
    Abstract: Liquid suspensions of tasimelteon and methods for their use.
    Type: Application
    Filed: July 31, 2023
    Publication date: November 23, 2023
    Inventors: Deepak Phadke, Mihael Polymeropoulos
  • Liquid tasimelteon formulations and methods of use thereof
    Patent number: 11759446
    Abstract: Liquid suspensions of tasimelteon and methods for their use.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: September 19, 2023
    Assignee: VANDA PHARMACEUTICALS INC.
    Inventors: Deepak Phadke, Mihael Polymeropoulos
  • METHOD OF IMPROVING SLEEP
    Publication number: 20220387374
    Abstract: The invention provides methods of improving sleep in a patient having a variant of the cryptochrome circadian clock 1 (CRY1) genotype associated with a circadian rhythm sleep disorder (CRSD) Delayed Sleep Wake Phase Disorder (DSWPD).
    Type: Application
    Filed: August 16, 2022
    Publication date: December 8, 2022
    Inventors: Mihael POLYMEROPOULOS, Sandra SMIESZEK
  • TASIMELTEON USE IN TREATING SLEEP ABERRATIONS
    Publication number: 20220347150
    Abstract: The invention relates generally to circadian rhythm disorders and, more particularly, to the treatment or prevention of circadian rhythm disorders based on an individual's HCN1 genotype. One aspect of the invention provides a method of treating an individual for delayed sleep time comprising: determining or having determined from a biological sample of the individual that the individual has a GG genotype at the rs12188518 single nucleotide polymorphism (SNP) locus; and administering to the individual once daily before a target bedtime a dose of tasimelteon effective to advance the sleep time of the individual. Other genotypes related with circadian rhythm disorders are CC at rs11248864 and AA at rs72762058.
    Type: Application
    Filed: June 29, 2020
    Publication date: November 3, 2022
    Inventors: Mihael Polymeropoulos, Sandra SMIESZEK
  • Method of improving sleep
    Patent number: 11458116
    Abstract: The invention provides methods of improving sleep in a patient having a variant of the cryptochrome circadian clock 1 (CRY 1) genotype associated with a circadian rhythm sleep disorder (CRSD) Delayed Sleep Wake Phase Disorder (DSWPD).
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: October 4, 2022
    Assignee: VANDA PHARMACEUTICALS INC.
    Inventors: Mihael Polymeropoulos, Sandra Smieszek
  • Treatment of Affective Disorders
    Publication number: 20220280471
    Abstract: Embodiments of the invention relate generally to the treatment of affective disorders and, more particularly, to the treatment of affective disorders in a patient of Majority Black African ancestry.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 8, 2022
    Inventors: Mihael Polymeropoulos, Christos Polymeropoulos, Changfu Xiao
  • METHODS FOR THE ADMINISTRATION OF ILOPERIDONE
    Publication number: 20220259660
    Abstract: The present invention relates to methods for the identification of genetic polymorphisms that may be associated with a risk for QT prolongation after treatment with iloperidone and related methods of administering iloperidone to patients with such polymorphisms.
    Type: Application
    Filed: April 8, 2022
    Publication date: August 18, 2022
    Inventors: Curt Wolfgang, Mihael Polymeropoulos, Christian Lavedan, Simona Volpi
  • METHOD OF IMPROVING SLEEP
    Publication number: 20220040140
    Abstract: The invention provides methods of improving sleep in a patient having a variant of the cryptochrome circadian clock 1 (CRY 1) genotype associated with a circadian rhythm sleep disorder (CRSD) Delayed Sleep Wake Phase Disorder (DSWPD).
    Type: Application
    Filed: February 13, 2020
    Publication date: February 10, 2022
    Inventors: Mihael POLYMEROPOULOS, Sandra SMIESZEK
  • Liquid tasimelteon formulations and methods of use thereof
    Patent number: 11202770
    Abstract: Liquid suspensions of tasimelteon and methods for their use.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: December 21, 2021
    Assignee: VANDA PHARMACEUTICALS INC.
    Inventors: Deepak Phadke, Mihael Polymeropoulos
  • Liquid Tasimelteon Formulations and Methods of Use Thereof
    Publication number: 20210212980
    Abstract: Liquid suspensions of tasimelteon and methods for their use.
    Type: Application
    Filed: March 29, 2021
    Publication date: July 15, 2021
    Inventors: Deepak Phadke, Mihael Polymeropoulos
  • Liquid Tasimelteon Formulations and Methods of Use Thereof
    Publication number: 20210177799
    Abstract: Liquid suspensions of tasimelteon and methods for their use.
    Type: Application
    Filed: December 11, 2020
    Publication date: June 17, 2021
    Inventors: Deepak Phadke, Mihael Polymeropoulos
  • Treatment of Affective Disorders
    Publication number: 20210059973
    Abstract: Embodiments of the invention relate generally to the treatment of affective disorders and, more particularly, to the treatment of affective disorders in a patient of Majority Black African ancestry.
    Type: Application
    Filed: August 2, 2018
    Publication date: March 4, 2021
    Inventors: Mihael Polymeropoulos, Christos Polymeropoulos, Changfu Xiao
  • METHODS FOR THE ADMINISTRATION OF ILOPERIDONE
    Publication number: 20190360047
    Abstract: The present invention relates to methods for the identification of genetic polymorphisms that may be associated with a risk for QT prolongation after treatment with iloperidone and related methods of administering iloperidone to patients with such polymorphisms.
    Type: Application
    Filed: May 8, 2019
    Publication date: November 28, 2019
    Inventors: Curt Wolfgang, Mihael Polymeropoulos, Christian Lavedan, Simona Volpi
  • TREATING NEURODEGENERATIVE DISEASE WITH FENOFIBRATE AND ANALOGS THEREOF
    Publication number: 20160220523
    Abstract: Provided herein are methods of treating or preventing a neurodegenerative by administering fenofibrate or an analog thereof.
    Type: Application
    Filed: September 18, 2014
    Publication date: August 4, 2016
    Applicant: Vanda Pharmaceuticals, Inc.
    Inventors: Mihael Polymeropoulos, Howard J. Federoff, Xiaomin Su
  • METHODS FOR THE ADMINISTRATION OF ILOPERIDONE
    Publication number: 20160053324
    Abstract: The present invention relates to methods for the identification of genetic polymorphisms that may be associated with a risk for QT prolongation after treatment with iloperidone and related methods of administering iloperidone to patients with such polymorphisms.
    Type: Application
    Filed: September 8, 2015
    Publication date: February 25, 2016
    Inventors: Curt Wolfgang, Mihael Polymeropoulos, Christian Lavedan, Simona Volpi
  • Methods for the administration of iloperidone
    Patent number: 9138432
    Abstract: The present invention relates to methods for treating a patient with iloperidone or a metabolite thereof, which patient is also being treated with fluoxetine, and lowering risk for QT prolongation.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: September 22, 2015
    Assignee: Vanda Pharmaceuticals, Inc.
    Inventors: Curt Wolfgang, Mihael Polymeropoulos
  • METHODS FOR THE ADMINISTRATION OF ILOPERIDONE
    Publication number: 20140128433
    Abstract: The present invention relates to methods for the identification of genetic polymorphisms that may be associated with a risk for QT prolongation after treatment with iloperidone and related methods of administering iloperidone to patients with such polymorphisms.
    Type: Application
    Filed: January 8, 2014
    Publication date: May 8, 2014
    Applicant: Vanda Pharmaceuticals, Inc.
    Inventors: Curt Wolfgang, Mihael Polymeropoulos
  • METHODS FOR THE ADMINISTRATION OF ILOPERIDONE
    Publication number: 20140045893
    Abstract: The present invention relates to methods for the identification of genetic polymorphisms that may be associated with a risk for QT prolongation after treatment with iloperidone and related methods of administering iloperidone to patients with such polymorphisms.
    Type: Application
    Filed: October 23, 2013
    Publication date: February 13, 2014
    Applicant: Vanda Pharmaceuticals, Inc.
    Inventors: Curt Wolfgang, Mihael Polymeropoulos
  • METHODS FOR THE ADMINISTRATION OF ILOPERIDONE
    Publication number: 20140039008
    Abstract: The present invention relates to methods for the identification of genetic polymorphisms that may be associated with a risk for QT prolongation after treatment with iloperidone and related methods of administering iloperidone to patients with such polymorphisms.
    Type: Application
    Filed: October 2, 2013
    Publication date: February 6, 2014
    Applicant: VANDA PHARMACEUTICALS, INC.
    Inventors: Curt Wolfgang, Mihael Polymeropoulos, Christian Lavedan, Simona Volpi
  • METHODS FOR THE ADMINISTRATION OF ILOPERIDONE
    Publication number: 20100063093
    Abstract: The present invention relates to methods for the identification of genetic polymorphisms that may be associated with a risk for QT prolongation after treatment with iloperidone and related methods of administering iloperidone to patients with such polymorphisms.
    Type: Application
    Filed: September 10, 2008
    Publication date: March 11, 2010
    Inventors: Curt Wolfgang, Mihael Polymeropoulos, Christian Lavedan, Simona Volpi