Abstract: A process for manufacturing a fiber or other device with a biocompatible coating for using the fiber in solid phase microextraction (SPME) of a small molecule of interest from a matrix. The process includes the step of coating the fiber/device with a coating of a biocompatible polymer and a solvent having solid phase microextraction (SPME) particles with pores dimensioned to absorb the small molecule of interest from the matrix suspended therein. The process also includes the steps of drying the coated fiber/device to remove the solvent and curing the dried coated fiber at an elevated temperature.

Abstract: A biocompatible coating for solid phase microextraction (SPME) of a small molecule from a biological matrix. The coating comprises SPME particles and a biocompatible polymer. The biocompatible polymer (e.g. polyacrylonitrile) reduces adsorption of proteins or macromolecules onto the SPME particles and allows the SPME particles to extract the small molecule from the matrix. A process for coating a flexible fiber with a biocompatible coating. The process comprises: coating the fiber with a suspension of SPME particles, the SPME particles being suspended in a solution of a biocompatible polymer and a solvent, the biocompatible polymer can comprise polyacrylonitrile (PAN); drying the coated fiber to remove the solvent; and curing the dried coated fiber at an elevated temperature.