Abstract: This disclosure relates to oral care appliances and methods of forming oral care appliances. A disclosed oral care mouthpiece includes a flexible membrane and a set of oral care elements attached to the flexible membrane. The set of oral care elements have a composition with a hardness of at least 50 Shore Type A (shA). Each oral care elements in the set of oral care elements has a minimum stiffness value higher than 4×10?8 newton meters and lower than 6×10?3 newton meters. The stiffness value and hardness of the oral care elements are both critical values for the disclosed appliances and methods. The stiffness value can be expressed as the product of the Young modulus of the oral care element and the moment of inertia of the oral care element divided by the length of the oral care element.

Abstract: The present invention relates to compositions, kits, and methods useful for directing an immune response to an epitope of an antigen in a subject, by sensitizing the subject to the epitope and/or by tolerizing the subject to the epitope. The sensitizing method comprises co-administering to the subject the epitope and an immunoglobulin M (IgM) constant region (IgM Fc region). The tolerizing method comprises co-administering to the subject the epitope and an immunoglobulin G (IgG) constant region (IgG Fc region) to the subject.

Abstract: The present invention relates to compositions, kits, and methods for preparing an autologous idiotype vaccine, or autologous anti-idiotype vaccine, for treatment of a B-cell malignancy based on the isotype(s) (class(es)) of immunoglobulins expressed by the malignancy; methods for treating B-cell malignancies; and methods for selecting a treatment for a subject having a B-cell malignancy.