Patents by Inventor Mihaela Skobe

Mihaela Skobe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VEGFR-3-ACTIVATING AGENTS AND ONCOLYTIC VIRUSES AND USES THEREOF FOR THE TREATMENT OF CANCER
    Publication number: 20230151070
    Abstract: In one aspect, provided herein are methods for treating cancer in a subject, comprising administering to a subject an oncolytic virus (e.g., an avian paramyxovirus (AMPV)) and a vascular endothelial growth factor (VEGF)-C agent, a VEGF-D agent, or a VEGF receptor (VEGFR)-3-activating agent. In another aspect, provided herein are oncolytic viruses (e.g. APMV) comprising a genome, wherein the genome comprises a transgene that comprises a nucleotide sequence encoding a VEGF-C agent, a VEGF-D agent or a VEGF receptor (VEGFR)-3-activating agent. In another aspect, provided herein are methods for treating cancer, comprising administering to a subject an oncolytic virus (e.g. APMV), wherein the oncolytic virus comprises a genome that comprises a transgene comprising a nucleotide sequence encoding a VEGF-C agent, a VEGF-D agent, or a VEGF receptor (VEGFR)-3-activating agent.
    Type: Application
    Filed: February 26, 2021
    Publication date: May 18, 2023
    Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Mihaela SKOBE, Andrew Kenneth EDWARDS, Ruben FERNANDEZ-RODRIGUEZ, Adolfo GARCIA-SASTRE, Ignacio MENA, Sara CUADRADO CASTAÑO
  • COMPOSITIONS AND METHODS COMPRISING VEGFR-2 AND VEGFR-3 ANTAGONISTS FOR THE TREATMENT OF METASTATIC DISEASE
    Publication number: 20120183547
    Abstract: The invention is directed to methods for inhibiting growth of tumor metastases in lymph nodes, lungs and other distant organ sites comprising administering one or more VEGFR-3 antagonist(s) and optionally one or more VEGFR-2 antagonist(s).
    Type: Application
    Filed: May 27, 2010
    Publication date: July 19, 2012
    Applicant: MOUNT SINAI SCHOOL OF MEDICINE
    Inventors: Mihaela Skobe, Suvendu Das
  • Photoimmunotherapies for cancer using combination therapies
    Patent number: 7498029
    Abstract: The present invention relates to photosensitizer immunoconjugate compositions and combination therapies for use in cancer related photodynamic treatments and diagnostic methods. Photosensitizer immunoconjugates comprising a photosensitizer conjugated to a tumor-specific and/or tumoricidial antibody and processes for the preparation thereof are described. The use of photosensitizer immunoconjugates (PICs) offers improved photosensitizer delivery specificity for diagnostic and therapeutic applications. Combination therapies to co-localize activated photosensitizer compounds and tumoricidal antibodies in tumor tissues are also described.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: March 3, 2009
    Assignee: The General Hospital Corporation
    Inventors: Tayyaba Hasan, Mark D. Savellano, Mihaela Skobe
  • Photoimmunotherapies for cancer using photosensitizer immunoconjugates and combination therapies
    Publication number: 20020197262
    Abstract: The present invention relates to photosensitizer immunoconjugate compositions and combination therapies for use in cancer related photodynamic treatments and diagnostic methods. Photosensitizer immunoconjugates comprising a photosensitizer conjugated to a tumor-specific and/or tumoricidial antibody and processes for the preparation thereof are described. The use of photosensitizer immunoconjugates (PICs) offers improved photosensitizer delivery specificity for diagnostic and therapeutic applications. Combination therapies to co-localize activated photosensitizer compounds and tumoricidal antibodies in tumor tissues are also described.
    Type: Application
    Filed: May 1, 2002
    Publication date: December 26, 2002
    Inventors: Tayyaba Hasan, Mark D. Savellano, Mihaela Skobe