Patents by Inventor Mihai Luchian Azoitei

Mihai Luchian Azoitei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AUTOMATED METHOD OF COMPUTATIONAL ENZYME IDENTIFICATION AND DESIGN
    Publication number: 20230045710
    Abstract: The invention provides computational methods for engineering, selecting, and/or identifying proteins with a desired activity. Further provided are automated computational design and screening methods to engineer proteins with desired functional activities including, but not limited to ligand binding, catalytic activity, substrate specificity, regioselectivity and/or stereoselectivity.
    Type: Application
    Filed: July 15, 2022
    Publication date: February 9, 2023
    Inventors: Alexandre ZANGHELLINI, Yih-En Andrew BAN, Eric Anthony ALTHOFF, Daniela GRABS, Mihai Luchian AZOITEI
  • Automated method of computational enzyme identification and design
    Patent number: 11393556
    Abstract: The invention provides computational methods for engineering, selecting, and/or identifying proteins with a desired activity. Further provided are automated computational design and screening methods to engineer proteins with desired functional activities including, but not limited to ligand binding, catalytic activity, substrate specificity, regioselectivity and/or stereoselectivity.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: July 19, 2022
    Assignee: Arzeda Corporation
    Inventors: Alexandre Zanghellini, Yih-En Andrew Ban, Eric Anthony Althoff, Daniela Grabs, Mihai Luchian Azoitei
  • Mutant polypeptides and uses thereof
    Patent number: 10519433
    Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: December 31, 2019
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Nadia Kadi, Adriana L. Botes, Mihai Luchian Azoitei, Yih-En A. Ban, Daniela Grabs-Röthlisberger, Alexander Pisarchik, Alexandre Zanghellini, Eric Althoff
  • AUTOMATED METHOD OF COMPUTATIONAL ENZYME IDENTIFICATION AND DESIGN
    Publication number: 20190325984
    Abstract: The invention provides computational methods for engineering, selecting, and/or identifying proteins with a desired activity. Further provided are automated computational design and screening methods to engineer proteins with desired functional activities including, but not limited to ligand binding, catalytic activity, substrate specificity, regioselectivity and/or stereoselectivity.
    Type: Application
    Filed: June 14, 2018
    Publication date: October 24, 2019
    Inventors: Alexandre ZANGHELLINI, Yih-En Andrew BAN, Eric Anthony ALTHOFF, Daniela GRABS, Mihai Luchian AZOITEI
  • Mutant polypeptides and uses thereof
    Patent number: 10214736
    Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: February 26, 2019
    Assignee: INVISTA North America S.à.r.l.
    Inventors: Eric Althoff, Nadia Kadi, Mihai Luchian Azoitei, Yih-En A. Ban, Daniela Grabs-Röthlisberger, Alexander Pisarchik, Alexandre Zanghellini, Adriana L. Botes
  • Automated method of computational enzyme identification and design
    Patent number: 10025900
    Abstract: The invention provides computational methods for engineering, selecting, and/or identifying proteins with a desired activity. Further provided are automated computational design and screening methods to engineer proteins with desired functional activities including, but not limited to ligand binding, catalytic activity, substrate specificity, regioselectivity and/or stereoselectivity.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 17, 2018
    Assignee: ARZEDA CORP.
    Inventors: Alexandre Zanghellini, Yih-En Andrew Ban, Eric Anthony Althoff, Daniela Grabs, Mihai Luchian Azoitei
  • MUTANT POLYPEPTIDES AND USES THEREOF
    Publication number: 20180030431
    Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.
    Type: Application
    Filed: May 12, 2017
    Publication date: February 1, 2018
    Applicant: INVISTA North America S.A.R.L.
    Inventors: Eric ALTHOFF, Nadia KADI, Mihai Luchian AZOITEI, Yih-En A. BAN, Daniela GRABS-RÖTHLISBERGER, Alexander PISARCHIK, Alexandre ZANGHELLINI, Adriana L. BOTES
  • Mutant polypeptides and uses thereof
    Patent number: 9683227
    Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: June 20, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Eric Althoff, Nadia Kadi, Mihai Luchian Azoitei, Yih-En A Ban, Daniela Grabs-Röthlisberger, Alexander Pisarchik, Alexandre Zanghellini, Adriana L. Botes
  • MUTANT POLYPEPTIDES AND USES THEREOF
    Publication number: 20160304852
    Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.
    Type: Application
    Filed: August 24, 2015
    Publication date: October 20, 2016
    Applicant: INVISTA S.a.r.l.
    Inventors: Adriana L. Botes, Nadia Kadi, Mihai Luchian Azoitei, Yih-En A. Ban, Daniela Grabs-Röthlisberger, Alexander Pisarchik, Alexandre Zanghellini, Eric Althoff
  • MUTANT POLYPEPTIDES AND USES THEREOF
    Publication number: 20160251645
    Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.
    Type: Application
    Filed: February 29, 2016
    Publication date: September 1, 2016
    Applicant: INVISTA North America S.a.r.l.
    Inventors: ADRIANA L. BOTES, Nadia Kadi, Mihai Luchian Azoitei, Yih-En A. Ban, Daniela Grabs-Röthlisberger, Alexander Pisarchik, Alexandre Zanghellini, Eric Althoff
  • AUTOMATED METHOD OF COMPUTATIONAL ENZYME IDENTIFICATION AND DESIGN
    Publication number: 20160063177
    Abstract: The invention provides computational methods for engineering, selecting, and/or identifying proteins with a desired activity. Further provided are automated computational design and screening methods to engineer proteins with desired functional activities including, but not limited to ligand binding, catalytic activity, substrate specificity, regioselectivity and/or stereoselectivity.
    Type: Application
    Filed: March 14, 2014
    Publication date: March 3, 2016
    Inventors: Alexandre ZANGHELLINI, Andrew Yih-En, Eric Anthony ALTHOFF, Daniela GRABS, Mihai Luchian AZOITEI
  • Mutant polypeptides and uses thereof
    Patent number: 9220742
    Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: December 29, 2015
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Adriana Botes, Nadia Kadi, Mihai Luchian Azoitei, Yih-En A Ban, Daniela Grabs-Röthlisberger, Alexander Pisarchik, Alexandre Zanghellini, Eric Althoff