Patents by Inventor Mihai V. Podgoreanu

Mihai V. Podgoreanu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for identifying altered effectiveness of beta blocker therapy
    Patent number: 10378056
    Abstract: The present invention provides a method of identifying a human subject as having an increased risk of altered effectiveness of beta blocker therapy, comprising detecting in the subject one or more single nucleotide polymorphism associated with increased risk of altered effectiveness of beta blocker therapy.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: August 13, 2019
    Assignee: Duke University
    Inventors: Miklos D. Kertai, Mihai V. Podgoreanu, Joseph P. Mathew, Yi-Ju Li
  • Methods and compositions for activation of sirtuins with Annexin A1 peptides
    Patent number: 10172915
    Abstract: The present invention provides a method of treating, ameliorating or inhibiting sirtuin-associated disorders and/or conditions in a subject in need thereof, by administering to the subject an effective amount of an ANXA1 peptide.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: January 8, 2019
    Assignee: Duke University
    Inventors: Zhiquan Zhang, Mihai V. Podgoreanu, Qing Ma, David S. Warner, Mark F. Newman
  • COMPOSITIONS AND METHODS FOR TREATING POST OPERATIVE COGNITIVE DYSFUNCTION AND NEUROINFLAMMATION WITH ANNEXIN A1 (ANXA1) PEPTIDES
    Publication number: 20180153952
    Abstract: The present disclosure provides compositions and methods for treating post-operative cognitive dysfunction with Annexin A1 (ANXA1) peptides.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 7, 2018
    Inventors: Zhiquan Zhang, Niccolo Terrando, Qing Ma, Mihai V. Podgoreanu, Joseph P. Mathew, Mark F. Newman
  • Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke
    Patent number: 9556486
    Abstract: The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. The present invention relates, in general, to perioperative renal dysfunction and, in particular, to methods of identifying individuals at risk of perioperative renal dysfunction. The present invention relates, in general, to perioperative stroke and, in particular, to methods of identifying individuals at risk of perioperative stroke.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: January 31, 2017
    Assignee: Duke University
    Inventors: Debra A. Schwinn, Ian Welsby, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Hilary P. Grocott, William D. White, Richard W. Morris, Joseph P. Mathew
  • COMPOSITIONS AND METHODS FOR IDENTIFYING ALTERED EFFECTIVENESS OF BETA BLOCKER THERAPY
    Publication number: 20170002417
    Abstract: The present invention provides a method of identifying a human subject as having an increased risk of altered effectiveness of beta blocker therapy, comprising detecting in the subject one or more single nucleotide polymorphism associated with increased risk of altered effectiveness of beta blocker therapy.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 5, 2017
    Inventors: Miklos D. Kertai, Mihai V. Podgoreanu, Joseph P. Mathew, Yi-Ju Li
  • Compositions and methods for the treatment of cardiac surgery-associated acute kidney injury with annexin A1 peptide
    Patent number: 9173918
    Abstract: The present invention provides a method of treating, ameliorating and/or preventing cardiac surgery-associated acute kidney injury (AKI) in a subject, comprising administering to the subject a therapeutically effective amount of an annexin A1 (ANXA1) peptide such that the AKI is treated, ameliorated and/or prevented.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: November 3, 2015
    Assignee: Duke University
    Inventors: Zhiquan Zhang, G. Burkhard Mackensen, Qing Ma, Mihai V. Podgoreanu
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF MYOCARDIAL ISCHEMIA/REPERFUSION INJURY WITH ANNEXIN A1 SHORT PEPTIDE
    Publication number: 20150231205
    Abstract: The present invention provides a method of treating, ameliorating or preventing myocardial ischemia/reperfusion injury in a subject in need thereof, by administering to the subject a therapeutically effective amount of an ANXA1short peptide (ANXA1sp).
    Type: Application
    Filed: January 27, 2015
    Publication date: August 20, 2015
    Inventors: Mihai V. Podgoreanu, Zhiquan Zhang, Qing Ma
  • Methods and Compositions for Activation of Sirtuins with Annexin A1 Peptides
    Publication number: 20150111830
    Abstract: The present invention provides a method of treating, ameliorating or inhibiting sirtuin-associated disorders and/or conditions in a subject in need thereof, by administering to the subject an effective amount of an ANXA1 peptide.
    Type: Application
    Filed: October 20, 2014
    Publication date: April 23, 2015
    Inventors: Zhiquan Zhang, Mihai V. Podgoreanu, Qing Ma, David S. Warner, Mark F. Newman
  • Compositions and methods for the treatment of myocardial ischemia/reperfusion injury with Annexin A1 short peptide
    Patent number: 8940697
    Abstract: The present invention provides a method of treating, ameliorating or preventing myocardial ischemia/reperfusion injury in a subject in need thereof, by administering to the subject a therapeutically effective amount of an annexin A1 short peptide (ANXA1sp).
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: January 27, 2015
    Assignee: Duke University
    Inventors: Mihai V. Podgoreanu, Zhiquan Zhang, Qing Ma
  • Compositions and Methods for the Treatment of Cardiac Surgery-Associated Acute Kidney Injury with Annexin A1 Peptide
    Publication number: 20140296149
    Abstract: The present invention provides a method of treating, ameliorating and/or preventing cardiac surgery-associated acute kidney injury (AKI) in a subject, comprising administering to the subject a therapeutically effective amount of an ANXA1 peptide such that the AKI is treated, ameliorated and/or prevented.
    Type: Application
    Filed: October 14, 2011
    Publication date: October 2, 2014
    Inventors: Zhiquan Zhang, G. Burkhard Mackensen, Qing Ma, Mihai V. Podgoreanu
  • METHODS OF IDENTIFYING INDIVIDUALS AT RISK OF PERIOPERATIVE BLEEDING, RENAL DYSFUNCTION OR STROKE
    Publication number: 20140141429
    Abstract: The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. The present invention relates, in general, to perioperative renal dysfunction and, in particular, to methods of identifying individuals at risk of perioperative renal dysfunction. The present invention relates, in general, to perioperative stroke and, in particular, to methods of identifying individuals at risk of perioperative stroke.
    Type: Application
    Filed: December 6, 2013
    Publication date: May 22, 2014
    Applicant: DUKE UNIVERSITY
    Inventors: Debra A. SCHWINN, Ian Welsby, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Hilary P. Grocott, William D. White, Richard W. Morris, Joseph P. Mathew
  • METHODS OF IDENTIFYING INDIVIDUALS AT RISK OF PERIOPERATIVE BLEEDING, RENAL DYSFUNCTION OR STROKE
    Publication number: 20120322667
    Abstract: The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. The present invention relates, in general, to perioperative renal dysfunction and, in particular, to methods of identifying individuals at risk of perioperative renal dysfunction. The present invention relates, in general, to perioperative stroke and, in particular, to methods of identifying individuals at risk of perioperative stroke.
    Type: Application
    Filed: April 24, 2012
    Publication date: December 20, 2012
    Applicant: DUKE UNIVERSITY
    Inventors: Debra A. Schwinn, Ian Welsby, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Hilary P. Grocott, William D. White, Richard W. Morris, Joseph P. Mathew
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF MYOCARDIAL ISCHEMIA/REPERFUSION INJURY WITH ANNEXIN A1 SHORT PEPTIDE
    Publication number: 20120270790
    Abstract: The present invention provides a method of treating, ameliorating or preventing myocardial ischemia/reperfusion injury in a subject in need thereof, by administering to the subject a therapeutically effective amount of an ANXA1short peptide (ANXA1sp).
    Type: Application
    Filed: October 15, 2010
    Publication date: October 25, 2012
    Applicant: Duke University
    Inventors: Mihai V. Podgoreanu, Zhiquan Zhang, Qing Ma
  • Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke
    Patent number: 8187807
    Abstract: The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. The present invention relates, in general, to perioperative renal dysfunction and, in particular, to methods of identifying individuals at risk of perioperative renal dysfunction. The present invention relates, in general, to perioperative stroke and, in particular, to methods of identifying individuals at risk of perioperative stroke.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: May 29, 2012
    Assignee: Duke University
    Inventors: Debra A. Schwinn, Ian Welsby, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Hilary P. Grocott, William D. White, Richard W. Morris, Joseph P. Mathew
  • Method of identifying individuals at risk of perioperative myocardial injury, major adverse cardiac events, cognitive decline, arrhythmias, depression or bleeding
    Publication number: 20100047775
    Abstract: The present invention relates to methods of identifying individuals at risk of perioperative myocardial injury, major adverse cardiac events, cognitive decline, arrhythmias, depression and bleeding.
    Type: Application
    Filed: April 24, 2006
    Publication date: February 25, 2010
    Inventors: Debra A Schwinn, Mihai V. Podgoreanu, Joseph P. Mathew, Hilary P. Grocott, William D. White, Richard W. Morris, Mark F. Newman, Barbara Phillips-Bute, Ian Welsby
  • METHODS AND COMPOSITIONS FOR IDENTIFYING INDIVIDUALS AT REDUCED RISK OF SEPSIS
    Publication number: 20090317821
    Abstract: The present invention provides a method of identifying a subject having a reduced risk of developing sepsis, comprising detecting at least one APOE3 allele in nucleic acid from the subject.
    Type: Application
    Filed: July 23, 2009
    Publication date: December 24, 2009
    Inventors: Debra A. Schwinn, Daniel Laskowitz, Mihai V. Podgoreanu, Eugene W. Moretti
  • Methods of identifying individuals at reduced risk of sepsis
    Patent number: 7592141
    Abstract: The present invention provides a method of identifying a subject having a reduced risk of developing sepsis, comprising detecting at least one APOE3 allele in nucleic acid from the subject.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: September 22, 2009
    Assignee: Duke University
    Inventors: Debra A. Schwinn, Daniel Laskowitz, Mihai V. Podgoreanu, Eugene W. Moretti
  • PREDICTORS OF LONG-TERM MORTALITY FOLLOWING CORONARY ARTERY BYPASS GRAFT SURGERY
    Publication number: 20090155792
    Abstract: The present invention relates, in general, to perioperative depression and, in particular, to methods of identifying individuals at risk of perioperative depression.
    Type: Application
    Filed: October 14, 2008
    Publication date: June 18, 2009
    Inventors: Mihai V. Podgoreanu, Joseph P. Mathew, Robert L. Lobato, Mark F. Newman, Mark Stafford-Smith, William D. White
  • Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke
    Publication number: 20090075271
    Abstract: The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. The present invention relates, in general, to perioperative renal dysfunction and, in particular, to methods of identifying individuals at risk of perioperative renal dysfunction. The present invention relates, in general, to perioperative stroke and, in particular, to methods of identifying individuals at risk of perioperative stroke.
    Type: Application
    Filed: February 29, 2008
    Publication date: March 19, 2009
    Applicant: DUKE UNIVERSITY
    Inventors: Debra A. Schwinn, Ian Welsby, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Hilary P. Grocott, William D. White, Richard W. Morris, Joseph P. Mathew
  • Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction
    Patent number: 7439019
    Abstract: The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. The present invention relates, in general, to perioperative renal dysfunction and, in particular, to methods of identifying individuals at risk of perioperative renal dysfunction. The present invention relates, in general, to perioperative stroke and, in particular, to methods of identifying individuals at risk of perioperative stroke.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: October 21, 2008
    Assignee: Duke University
    Inventors: Debra A. Schwinn, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman